Entry | Database: PDB / ID: 5x68 |
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Title | Crystal Structure of Human KMO |
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Components | Kynurenine 3-monooxygenase |
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Keywords | OXIDOREDUCTASE / monooxygenase / flavin reduction |
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Function / homology | Function and homology information
L-kynurenine metabolic process / positive regulation of glutamate secretion, neurotransmission / : / kynurenine 3-monooxygenase / kynurenine 3-monooxygenase activity / kynurenine metabolic process / quinolinate biosynthetic process / kynurenic acid biosynthetic process / anthranilate metabolic process / : ...L-kynurenine metabolic process / positive regulation of glutamate secretion, neurotransmission / : / kynurenine 3-monooxygenase / kynurenine 3-monooxygenase activity / kynurenine metabolic process / quinolinate biosynthetic process / kynurenic acid biosynthetic process / anthranilate metabolic process / : / NAD(P)H oxidase H2O2-forming activity / 'de novo' NAD biosynthetic process from tryptophan / tryptophan catabolic process / Tryptophan catabolism / NAD metabolic process / cellular response to interleukin-1 / response to salt stress / FAD binding / flavin adenine dinucleotide binding / cellular response to lipopolysaccharide / mitochondrial outer membrane / membrane => GO:0016020 / mitochondrion / extracellular space / cytosolSimilarity search - Function Kynurenine 3-monooxygenase / FAD-binding domain / FAD binding domain / FAD/NAD(P)-binding domain / FAD/NAD(P)-binding domain / 3-Layer(bba) Sandwich / FAD/NAD(P)-binding domain superfamily / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.1 Å |
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Authors | Kim, H.T. / Hwang, K.Y. |
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Citation | Journal: Cell Chem Biol / Year: 2018 Title: Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase Authors: Kim, H.T. / Na, B.K. / Chung, J. / Kim, S. / Kwon, S.K. / Cha, H. / Son, J. / Cho, J.M. / Hwang, K.Y. |
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History | Deposition | Feb 21, 2017 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Feb 21, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Feb 28, 2018 | Group: Database references / Category: citation Item: _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_PubMed |
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Revision 1.2 | May 2, 2018 | Group: Data collection / Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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