登録情報 | データベース: PDB / ID: 5wy1 |
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タイトル | Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) |
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要素 | DNA (cytosine-5)-methyltransferase 1 |
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キーワード | TRANSFERASE / CpG sequence / mutant / epigenetics / hemimethylated DNA |
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機能・相同性 | 機能・相同性情報
SUMOylation of DNA methylation proteins / chromosomal DNA methylation maintenance following DNA replication / negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching / epigenetic programming of gene expression / PRC2 methylates histones and DNA / DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates / cellular response to bisphenol A / DNA-methyltransferase activity / negative regulation of vascular associated smooth muscle cell apoptotic process / DNA (cytosine-5-)-methyltransferase ...SUMOylation of DNA methylation proteins / chromosomal DNA methylation maintenance following DNA replication / negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching / epigenetic programming of gene expression / PRC2 methylates histones and DNA / DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates / cellular response to bisphenol A / DNA-methyltransferase activity / negative regulation of vascular associated smooth muscle cell apoptotic process / DNA (cytosine-5-)-methyltransferase / DNA (cytosine-5-)-methyltransferase activity / S-adenosylmethionine metabolic process / female germ cell nucleus / methyl-CpG binding / DNA methylation-dependent heterochromatin formation / lncRNA binding / germ cell nucleus / negative regulation of gene expression via chromosomal CpG island methylation / heterochromatin / pericentric heterochromatin / cellular response to transforming growth factor beta stimulus / positive regulation of vascular associated smooth muscle cell proliferation / replication fork / methyltransferase activity / promoter-specific chromatin binding / nuclear estrogen receptor binding / cellular response to amino acid stimulus / histone deacetylase binding / regulation of cell population proliferation / regulation of gene expression / methylation / response to xenobiotic stimulus / protein domain specific binding / negative regulation of gene expression / negative regulation of DNA-templated transcription / DNA-templated transcription / chromatin binding / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / enzyme binding / protein-containing complex / DNA binding / RNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 DNA (cytosine-5)-methyltransferase 1-like / DNA (cytosine-5)-methyltransferase 1, replication foci domain / Cytosine specific DNA methyltransferase replication foci domain / DMAP1-binding Domain / DMAP1-binding Domain / DMAP1-binding domain / DMAP1-binding domain profile. / : / DNA methylase, C-5 cytosine-specific, conserved site / C-5 cytosine-specific DNA methylases C-terminal signature. ...DNA (cytosine-5)-methyltransferase 1-like / DNA (cytosine-5)-methyltransferase 1, replication foci domain / Cytosine specific DNA methyltransferase replication foci domain / DMAP1-binding Domain / DMAP1-binding Domain / DMAP1-binding domain / DMAP1-binding domain profile. / : / DNA methylase, C-5 cytosine-specific, conserved site / C-5 cytosine-specific DNA methylases C-terminal signature. / CXXC zinc finger domain / DNA methylase, C-5 cytosine-specific, active site / C-5 cytosine-specific DNA methylases active site. / Zinc finger, CXXC-type / Zinc finger CXXC-type profile. / C-5 cytosine-specific DNA methylase (Dnmt) domain profile. / C-5 cytosine methyltransferase / C-5 cytosine-specific DNA methylase / Bromo adjacent homology domain / BAH domain / Bromo adjacent homology (BAH) domain superfamily / Bromo adjacent homology (BAH) domain / BAH domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.27 Å |
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データ登録者 | Kanada, K. / Takeshita, K. / Suetake, I. / Tajima, S. / Nakagawa, A. |
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資金援助 | 日本, 6件 組織 | 認可番号 | 国 |
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Japan Society for the Promotion of Science | JP23770145 | 日本 | Japan Science and Technology Agency | | 日本 | Japan Society for the Promotion of Science | JP24570153 | 日本 | Japan Society for the Promotion of Science | JP22370053 | 日本 | Japan Society for the Promotion of Science/the Ministry of Education, Culture, Sports, Science and Technology | JP 25291025 | 日本 | the National Project on Protein Structural and Functional Analyses | | 日本 |
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引用 | ジャーナル: J. Biochem. / 年: 2017 タイトル: Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1 著者: Kanada, K. / Takeshita, K. / Suetake, I. / Tajima, S. / Nakagawa, A. |
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履歴 | 登録 | 2017年1月10日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2017年5月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年10月18日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2023年11月22日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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