登録情報 | データベース: PDB / ID: 5wmd |
---|
タイトル | N-terminal bromodomain of BRD4 in complex with OTX-015 |
---|
要素 | Bromodomain-containing protein 4 |
---|
キーワード | TRANSCRIPTION/TRANSCRIPTION INHIBITOR / bromodomain / BRD4 / transcription / OTX-015 / transcription-transcription inhibitor complex |
---|
機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.27 Å |
---|
データ登録者 | Zhang, Y. |
---|
引用 | ジャーナル: Cancer Discov / 年: 2018 タイトル: BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. 著者: Ozer, H.G. / El-Gamal, D. / Powell, B. / Hing, Z.A. / Blachly, J.S. / Harrington, B. / Mitchell, S. / Grieselhuber, N.R. / Williams, K. / Lai, T.H. / Alinari, L. / Baiocchi, R.A. / Brinton, L. ...著者: Ozer, H.G. / El-Gamal, D. / Powell, B. / Hing, Z.A. / Blachly, J.S. / Harrington, B. / Mitchell, S. / Grieselhuber, N.R. / Williams, K. / Lai, T.H. / Alinari, L. / Baiocchi, R.A. / Brinton, L. / Baskin, E. / Cannon, M. / Beaver, L. / Goettl, V.M. / Lucas, D.M. / Woyach, J.A. / Sampath, D. / Lehman, A.M. / Yu, L. / Zhang, J. / Ma, Y. / Zhang, Y. / Spevak, W. / Shi, S. / Severson, P. / Shellooe, R. / Carias, H. / Tsang, G. / Dong, K. / Ewing, T. / Marimuthu, A. / Tantoy, C. / Walters, J. / Sanftner, L. / Rezaei, H. / Nespi, M. / Matusow, B. / Habets, G. / Ibrahim, P. / Zhang, C. / Mathe, E.A. / Bollag, G. / Byrd, J.C. / Lapalombella, R. |
---|
履歴 | 登録 | 2017年7月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2018年8月1日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2019年2月13日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
---|
改定 1.2 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|