登録情報 データベース : PDB / ID : 6dml 構造の表示 ダウンロードとリンクタイトル A multiconformer ligand model of 3,5 dimethylisoxaxole bound to the bromodomain of human BRD4 要素Bromodomain-containing protein 4 詳細 キーワード transcription/transcription inhibitor / Complex / multiconformer model / TRANSCRIPTION / transcription-transcription inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / P-TEFb complex binding / negative regulation of DNA damage checkpoint / host-mediated suppression of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / RNA polymerase II CTD heptapeptide repeat kinase activity / : / histone reader activity / condensed nuclear chromosome ... RNA polymerase II C-terminal domain binding / P-TEFb complex binding / negative regulation of DNA damage checkpoint / host-mediated suppression of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / RNA polymerase II CTD heptapeptide repeat kinase activity / : / histone reader activity / condensed nuclear chromosome / transcription coregulator activity / positive regulation of transcription elongation by RNA polymerase II / p53 binding / chromosome / regulation of inflammatory response / histone binding / Potential therapeutics for SARS / transcription coactivator activity / positive regulation of canonical NF-kappaB signal transduction / transcription cis-regulatory region binding / chromatin remodeling / protein serine/threonine kinase activity / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / chromatin / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / Brdt, bromodomain, repeat I / Brdt, bromodomain, repeat II / NET domain superfamily / NET domain profile. / : / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / Brdt, bromodomain, repeat I / Brdt, bromodomain, repeat II / NET domain superfamily / NET domain profile. / : / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / bromo domain / Bromodomain (BrD) profile. / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 1.5 Å 詳細データ登録者 Hudson, B.M. / van Zundert, G. / Keedy, D.A. / Fonseca, R. / Heliou, A. / Suresh, P. / Borrelli, K. / Day, T. / Fraser, J.S. / van den Bedem, H. 引用ジャーナル : J. Med. Chem. / 年 : 2018タイトル : qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
著者 :
van Zundert, G.C.P. / Hudson, B.M. / de Oliveira, S.H.P. / Keedy, D.A. / Fonseca, R. / Heliou, A. / Suresh, P. / Borrelli, K. / Day, T. / Fraser, J.S. / van den Bedem, H. 残り1件を表示 表示を減らす#1: ジャーナル : ChemMedChem / 年 : 2014タイトル : Naphthyridines as novel BET family bromodomain inhibitors.
著者 :
Mirguet, O. / Lamotte, Y. / Chung, C.W. / Bamborough, P. / Delannee, D. / Bouillot, A. / Gellibert, F. / Krysa, G. / Lewis, A. / Witherington, J. / Huet, P. / Dudit, Y. / Trottet, L. / Nicodeme, E. 履歴 登録 2018年6月5日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2018年12月19日 Provider : repository / タイプ : Initial release改定 1.1 2019年4月24日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID / _citation_author.name 改定 1.2 2024年3月13日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession改定 1.3 2024年5月1日 Group : Structure summary / カテゴリ : audit_author / Item : _audit_author.name
すべて表示 表示を減らす Remark 0 THIS ENTRY 6DML REFLECTS AN ALTERNATIVE MODELING OF THE ORIGINAL DATA IN 4BW3, DETERMINED BY C. ... THIS ENTRY 6DML REFLECTS AN ALTERNATIVE MODELING OF THE ORIGINAL DATA IN 4BW3, DETERMINED BY C.CHUNG,O.MIRGUET,Y.LAMOTTE,P.BAMBOROUGH,D.DELANNEE,A.BOUILLOT,F.GELLIBERT,G.KRYSA,A.LEWIS,J.WITHERINGTON,P.HUET,Y.DUDIT,L.TROTTET,E.NICODEME