Entry Database : PDB / ID : 5n2m Structure visualization Downloads & linksTitle Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue ComponentsBromodomain-containing protein 4 Details Keywords TRANSCRIPTION / Structural Genomics / Structural Genomics Consortium / SGCFunction / homology Function and homology informationFunction Domain/homology Component
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ... RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus Similarity search - Function Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.54 Å DetailsAuthors Tallant, C. / Slavish, P.J. / Siejka, P. / Bharatham, N. / Shadrick, W.R. / Chai, S. / Young, B.M. / Boyd, V.A. / Heroven, C. / Wiggers, H.J. ...Tallant, C. / Slavish, P.J. / Siejka, P. / Bharatham, N. / Shadrick, W.R. / Chai, S. / Young, B.M. / Boyd, V.A. / Heroven, C. / Wiggers, H.J. / Picaud, S. / Fedorov, O. / Krojer, T. / Chen, T. / Lee, R.E. / Guy, R.K. / Shelat, A.A. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S. / Structural Genomics Consortium (SGC) CitationJournal : To Be Published Title : Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogueAuthors: Tallant, C. / Slavish, P.J. / Siejka, P. / Bharatham, N. / Shadrick, W.R. / Chai, S. / Young, B.M. / Boyd, V.A. / Heroven, C. / Wiggers, H.J. / Picaud, S. / Fedorov, O. / Krojer, T. / Chen, ... Authors : Tallant, C. / Slavish, P.J. / Siejka, P. / Bharatham, N. / Shadrick, W.R. / Chai, S. / Young, B.M. / Boyd, V.A. / Heroven, C. / Wiggers, H.J. / Picaud, S. / Fedorov, O. / Krojer, T. / Chen, T. / Lee, R.E. / Guy, R.K. / Shelat, A.A. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S. / Structural Genomics Consortium (SGC) History Deposition Feb 7, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 28, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less