登録情報 | データベース: PDB / ID: 5wi4 |
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タイトル | CRYSTAL STRUCTURE OF DYNLT1/TCTEX-1 IN COMPLEX WITH ARHGEF2 |
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要素 | Dynein light chain Tctex-type 1,Rho guanine nucleotide exchange factor 2 |
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キーワード | MOTOR PROTEIN / DYNEIN LIGHT CHAIN / RHO GEF / CARGO TRANSPORT |
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機能・相同性 | 機能・相同性情報
negative regulation of podosome assembly / guanyl-nucleotide exchange factor activity => GO:0005085 / guanyl-nucleotide exchange factor activity => GO:0005085 / : / small GTPase binding => GO:0031267 / small GTPase binding => GO:0031267 / secretory vesicle / NRAGE signals death through JNK / G alpha (12/13) signalling events / : ...negative regulation of podosome assembly / guanyl-nucleotide exchange factor activity => GO:0005085 / guanyl-nucleotide exchange factor activity => GO:0005085 / : / small GTPase binding => GO:0031267 / small GTPase binding => GO:0031267 / secretory vesicle / NRAGE signals death through JNK / G alpha (12/13) signalling events / : / asymmetric neuroblast division / GTP-dependent protein binding / cellular response to muramyl dipeptide / positive regulation of neuron migration / regulation of G protein-coupled receptor signaling pathway / negative regulation of microtubule depolymerization / regulation of Rho protein signal transduction / cytoplasmic dynein complex / podosome / cytoskeletal motor activity / cytoplasmic microtubule / establishment of mitotic spindle orientation / bicellular tight junction / postsynaptic density, intracellular component / axonal growth cone / positive regulation of neuron differentiation / Neutrophil degranulation / photoreceptor inner segment / dendritic shaft / actin filament organization / cell morphogenesis / negative regulation of ERK1 and ERK2 cascade / ruffle membrane / positive regulation of neuron projection development / negative regulation of neurogenesis / spindle / positive regulation of interleukin-6 production / G-protein beta-subunit binding / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation / lamellipodium / positive regulation of NF-kappaB transcription factor activity / cell body / growth cone / cytoplasmic vesicle / microtubule binding / microtubule / vesicle / postsynaptic density / cytoskeleton / intracellular signal transduction / cell division / innate immune response / neuronal cell body / glutamatergic synapse / Golgi apparatus / positive regulation of transcription by RNA polymerase II / protein-containing complex / identical protein binding / metal ion binding / cytoplasm類似検索 - 分子機能 Dynein light chain Tctex-1 like / Tctex-1-like superfamily / Tctex-1 family / ARHGEF2, PH domain / ARHGEF1-like, PH domain / PH domain / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain ...Dynein light chain Tctex-1 like / Tctex-1-like superfamily / Tctex-1 family / ARHGEF2, PH domain / ARHGEF1-like, PH domain / PH domain / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / PH-like domain superfamily類似検索 - ドメイン・相同性 Dynein light chain Tctex-type 1 / Rho guanine nucleotide exchange factor 2類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
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データ登録者 | Balan, M. / Ishiyama, N. / Marshall, C.B. / Ikura, M. |
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資金援助 | カナダ, 2件 組織 | 認可番号 | 国 |
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Cancer Research Society (CRS) | CRS 14014 | カナダ | Canada Foundation for Innovation | | カナダ |
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引用 | ジャーナル: Sci Signal / 年: 2017 タイトル: MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity. 著者: Sandi, M.J. / Marshall, C.B. / Balan, M. / Coyaud, E. / Zhou, M. / Monson, D.M. / Ishiyama, N. / Chandrakumar, A.A. / La Rose, J. / Couzens, A.L. / Gingras, A.C. / Raught, B. / Xu, W. / ...著者: Sandi, M.J. / Marshall, C.B. / Balan, M. / Coyaud, E. / Zhou, M. / Monson, D.M. / Ishiyama, N. / Chandrakumar, A.A. / La Rose, J. / Couzens, A.L. / Gingras, A.C. / Raught, B. / Xu, W. / Ikura, M. / Morrison, D.K. / Rottapel, R. |
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履歴 | 登録 | 2017年7月18日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年11月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月4日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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