登録情報 | データベース: PDB / ID: 5vhd |
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タイトル | DHX36 with an N-terminal truncation bound to ADP-AlF4 |
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要素 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 |
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キーワード | HYDROLASE |
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機能・相同性 | 機能・相同性情報
DEx/H-box helicases activate type I IFN and inflammatory cytokines production / positive regulation of intracellular mRNA localization / positive regulation of hematopoietic progenitor cell differentiation / positive regulation of cardioblast differentiation / positive regulation of mRNA 3'-end processing / positive regulation of telomere maintenance via telomere lengthening / pre-miRNA binding / G-quadruplex DNA unwinding / RNA secondary structure unwinding / G-quadruplex DNA binding ...DEx/H-box helicases activate type I IFN and inflammatory cytokines production / positive regulation of intracellular mRNA localization / positive regulation of hematopoietic progenitor cell differentiation / positive regulation of cardioblast differentiation / positive regulation of mRNA 3'-end processing / positive regulation of telomere maintenance via telomere lengthening / pre-miRNA binding / G-quadruplex DNA unwinding / RNA secondary structure unwinding / G-quadruplex DNA binding / regulation of transcription by RNA polymerase III / 3'-UTR-mediated mRNA destabilization / positive regulation of dendritic spine morphogenesis / mRNA 3'-UTR AU-rich region binding / positive regulation of cytoplasmic translation / cellular response to arsenite ion / telomerase RNA binding / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / regulation of embryonic development / positive regulation of transcription initiation by RNA polymerase II / regulation of mRNA stability / DNA helicase activity / mRNA 3'-UTR binding / mRNA 5'-UTR binding / cytoplasmic stress granule / cellular response to UV / cellular response to heat / G-quadruplex RNA binding / spermatogenesis / perikaryon / DNA helicase / positive regulation of canonical NF-kappaB signal transduction / defense response to virus / chromosome, telomeric region / RNA helicase activity / cell differentiation / negative regulation of translation / RNA helicase / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / axon / innate immune response / dendrite / positive regulation of gene expression / magnesium ion binding / positive regulation of transcription by RNA polymerase II / ATP hydrolysis activity / mitochondrion / RNA binding / ATP binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation / DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site / DEAH-box subfamily ATP-dependent helicases signature. / DEAD/DEAH box helicase ...: / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation / DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site / DEAH-box subfamily ATP-dependent helicases signature. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / TETRAFLUOROALUMINATE ION / ATP-dependent DNA/RNA helicase DHX36類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Bos taurus (ウシ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.55 Å |
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データ登録者 | Chen, M. / Ferre-D'Amare, A. |
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引用 | ジャーナル: Nature / 年: 2018 タイトル: Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. 著者: Chen, M.C. / Tippana, R. / Demeshkina, N.A. / Murat, P. / Balasubramanian, S. / Myong, S. / Ferre-D'Amare, A.R. |
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履歴 | 登録 | 2017年4月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年6月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年6月27日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2018年7月4日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年3月13日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.4 | 2024年4月3日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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