登録情報 | データベース: PDB / ID: 5vdc |
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タイトル | Crystal structure of the human DPF2 tandem PHD finger domain |
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要素 | Zinc finger protein ubi-d4 |
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キーワード | GENE REGULATION / Histone Reader / Tandem PHD Finger / AML / Myeloid Differentiation |
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機能・相同性 | 機能・相同性情報
negative regulation of myeloid progenitor cell differentiation / H3K9me3 modified histone binding / nBAF complex / regulation of G0 to G1 transition / Regulation of MITF-M-dependent genes involved in pigmentation / regulation of nucleotide-excision repair / regulation of mitotic metaphase/anaphase transition / SWI/SNF complex / positive regulation of double-strand break repair / positive regulation of stem cell population maintenance ...negative regulation of myeloid progenitor cell differentiation / H3K9me3 modified histone binding / nBAF complex / regulation of G0 to G1 transition / Regulation of MITF-M-dependent genes involved in pigmentation / regulation of nucleotide-excision repair / regulation of mitotic metaphase/anaphase transition / SWI/SNF complex / positive regulation of double-strand break repair / positive regulation of stem cell population maintenance / regulation of G1/S transition of mitotic cell cycle / apoptotic signaling pathway / lysine-acetylated histone binding / transcription corepressor activity / nervous system development / chromatin remodeling / intracellular membrane-bounded organelle / centrosome / chromatin / apoptotic process / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding / cytosol類似検索 - 分子機能 : / DPF1-3, N-terminal domain / DPF1-3, N-terminal / Zinc/RING finger domain, C3HC4 (zinc finger) / Herpes Virus-1 / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / PHD-finger / Zinc finger C2H2 type domain signature. ...: / DPF1-3, N-terminal domain / DPF1-3, N-terminal / Zinc/RING finger domain, C3HC4 (zinc finger) / Herpes Virus-1 / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / PHD-finger / Zinc finger C2H2 type domain signature. / Zinc finger PHD-type signature. / Zinc finger C2H2-type / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger, FYVE/PHD-type / Zinc finger, RING/FYVE/PHD-type / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 1.6 Å |
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データ登録者 | Huber, F.M. / Davenport, A.M. / Hoelz, A. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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Heritage Medical Research Institute | | 米国 | Howard Hughes Medical Institute (HHMI) | | 米国 |
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引用 | ジャーナル: Proc. Natl. Acad. Sci. U.S.A. / 年: 2017 タイトル: Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. 著者: Huber, F.M. / Greenblatt, S.M. / Davenport, A.M. / Martinez, C. / Xu, Y. / Vu, L.P. / Nimer, S.D. / Hoelz, A. |
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履歴 | 登録 | 2017年4月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年5月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年6月7日 | Group: Database references |
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改定 1.2 | 2017年6月21日 | Group: Database references / カテゴリ: citation Item: _citation.country / _citation.journal_id_ASTM ..._citation.country / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2017年9月27日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2019年11月20日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.5 | 2024年3月6日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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