登録情報 | データベース: PDB / ID: 5v9i |
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タイトル | Crystal structure of catalytic domain of G9a with MS0105 |
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要素 | Histone-lysine N-methyltransferase EHMT2 |
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キーワード | TRANSFERASE / EHMT2 / BAT8 / methyltransferase / Structural Genomics / Structural Genomics Consortium / SGC |
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機能・相同性 | 機能・相同性情報
phenotypic switching / histone H3K56 methyltransferase activity / neuron fate specification / [histone H3]-lysine9 N-methyltransferase / peptidyl-lysine dimethylation / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / histone H3K27 methyltransferase activity / synaptonemal complex assembly / negative regulation of autophagosome assembly ...phenotypic switching / histone H3K56 methyltransferase activity / neuron fate specification / [histone H3]-lysine9 N-methyltransferase / peptidyl-lysine dimethylation / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / histone H3K27 methyltransferase activity / synaptonemal complex assembly / negative regulation of autophagosome assembly / oocyte development / C2H2 zinc finger domain binding / protein-lysine N-methyltransferase activity / fertilization / cellular response to cocaine / organ growth / DNA methylation-dependent constitutive heterochromatin formation / negative regulation of gene expression via chromosomal CpG island methylation / Transcriptional Regulation by E2F6 / spermatid development / regulation of DNA replication / RNA Polymerase I Transcription Initiation / Transcriptional Regulation by VENTX / behavioral response to cocaine / Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / epigenetic regulation of gene expression / cellular response to starvation / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / transcription corepressor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / promoter-specific chromatin binding / Regulation of TP53 Activity through Methylation / PKMTs methylate histone lysines / p53 binding / Senescence-Associated Secretory Phenotype (SASP) / nuclear speck / chromatin / negative regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleus類似検索 - 分子機能 Histone-lysine N-methyltransferase EHMT2 / Histone-lysine N-methyltransferase EHMT1/EHMT2 / : / Histone-lysine N-methyltransferase EHMT1/EHMT2, Cys-rich region / Pre-SET motif / Pre-SET domain / Pre-SET domain profile. / N-terminal to some SET domains / Beta-clip-like / SET domain ...Histone-lysine N-methyltransferase EHMT2 / Histone-lysine N-methyltransferase EHMT1/EHMT2 / : / Histone-lysine N-methyltransferase EHMT1/EHMT2, Cys-rich region / Pre-SET motif / Pre-SET domain / Pre-SET domain profile. / N-terminal to some SET domains / Beta-clip-like / SET domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain / SET domain superfamily / SET domain profile. / SET domain / Ankyrin repeat / Beta Complex / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Mainly Beta類似検索 - ドメイン・相同性 Chem-90P / S-ADENOSYLMETHIONINE / Histone-lysine N-methyltransferase EHMT2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.74 Å |
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データ登録者 | Dong, A. / Zeng, H. / Liu, J. / Xiong, Y. / Babault, N. / Jin, J. / Walker, J.R. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. ...Dong, A. / Zeng, H. / Liu, J. / Xiong, Y. / Babault, N. / Jin, J. / Walker, J.R. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / Wu, H. / Brown, P.J. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: to be published タイトル: Crystal structure of catalytic domain of G9a with MS0105 著者: Zeng, H. / Dong, A. / Liu, J. / Xiong, Y. / Babault, N. / Jin, J. / Walker, J.R. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / Wu, H. / Brown, P.J. |
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履歴 | 登録 | 2017年3月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年3月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id |
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