PDB-5v8w: Crystal structure of human Integrator IntS9-IntS11 CTD complex

ID or keywords:

Entry

Database: PDB / ID: 5v8w

Title

Crystal structure of human Integrator IntS9-IntS11 CTD complex

Components

Integrator complex subunit 11
Integrator complex subunit 9

Keywords

HYDROLASE / snRNA processing /

integrator complex

Function / homology

Function and homology information

snRNA processing /

integrator complex / snRNA 3'-end processing / regulation of transcription elongation by RNA polymerase II /

Hydrolases; Acting on ester bonds; Endoribonucleases producing 3'-phosphomonoesters / RNA polymerase II transcribes snRNA genes / RNA endonuclease activity / negative regulation of transforming growth factor beta receptor signaling pathway / blood microparticle /

nucleoplasm ...
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

SIRAS / Resolution: 2.1 Å

Authors

Wu, Y. / Tong, L.

Funding support

United States, 2items

Organization	Grant number	Country
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)	R35GM118093	United States
National Institutes of Health/Office of the Director	S10OD012018	United States

Citation

Journal: Proc. Natl. Acad. Sci. U.S.A. / Year: 2017
Title: Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.
Authors: Wu, Y. / Albrecht, T.R. / Baillat, D. / Wagner, E.J. / Tong, L.

History

Deposition	Mar 22, 2017	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Apr 12, 2017	Provider: repository / Type: Initial release
Revision 1.1	Apr 26, 2017	Group: Database references
Revision 1.2	May 10, 2017	Group: Database references
Revision 1.3	Sep 27, 2017	Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
Revision 1.4	Jan 1, 2020	Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	5v8w.cif.gz	301.3 KB	Display	PDBx/mmCIF format
PDB format	pdb5v8w.ent.gz	256.5 KB	Display	PDB format
PDBx/mmJSON format	5v8w.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/v8/5v8w ftp://data.pdbj.org/pub/pdb/validation_reports/v8/5v8w	HTTPS FTP

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Related structure data

Similar structure data	5oqd-2 2yd1-d 4mf7-d 1nhy-d 1ibx-d 5lhy-14 1sn8-d 1rfe-d 4uyr-d 5lhy-4 Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

Similar structure data

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#187 - Jul 2015 New Delhi Metallo-β-Lactamase similarity (2) #67 - Jul 2005 TATA-Binding Protein similarity (1) #112 - Apr 2009 Oct and Sox Transcription Factors similarity (1) #105 - Sep 2008 Ribonuclease A similarity (2)

Deposited unit

A: Integrator complex subunit 9

B: Integrator complex subunit 11

C: Integrator complex subunit 9

D: Integrator complex subunit 11

E: Integrator complex subunit 9

F: Integrator complex subunit 11

G: Integrator complex subunit 9

H: Integrator complex subunit 11

86.7 kDa, 8 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Integrator complex subunit 9

B: Integrator complex subunit 11

defined by author&software
21.7 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

C: Integrator complex subunit 9

D: Integrator complex subunit 11

defined by author&software
Evidence: gel filtration, immunoprecipitation
21.7 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

3

E: Integrator complex subunit 9

F: Integrator complex subunit 11

defined by author&software
21.7 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

4

G: Integrator complex subunit 9

H: Integrator complex subunit 11

defined by author&software
21.7 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	63.010, 67.780, 98.585
Angle α, β, γ (deg.)	90.00, 100.65, 90.00
Int Tables number	4
Space group name H-M	P12₁1

#1: Protein	Integrator complex subunit 9 / / Int9 / Protein related to CPSF subunits of 74 kDa / RC-74 Mass: 9003.422 Da / Num. of mol.: 4 / Fragment: C-terminal domain (UNP residues 582-658) Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: INTS9, RC74 / Production host: Escherichia coli (E. coli) / References: UniProt: Q9NV88
#2: Protein	Integrator complex subunit 11 / / Int11 / Cleavage and polyadenylation-specific factor 3-like protein / CPSF3-like protein / Protein ...Int11 / Cleavage and polyadenylation-specific factor 3-like protein / CPSF3-like protein / Protein related to CPSF subunits of 68 kDa / RC-68 Mass: 12673.415 Da / Num. of mol.: 4 / Fragment: C-terminal domain (UNP residues 491-600) Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: CPSF3L, INTS11, RC68 / Production host: Escherichia coli (E. coli) References: UniProt: Q5TA45, Hydrolases; Acting on ester bonds; Endoribonucleases producing 3'-phosphomonoesters
#3: Water	ChemComp-HOH / water / Water Mass: 18.015 Da / Num. of mol.: 419 / Source method: isolated from a natural source / Formula: H₂O

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.39 Å³/Da / Density % sol: 48.45 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, sitting drop / pH: 6.5 / Details: 0.1M Bis-Tris pH 6.5, 21-24% PEG 3350

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Data collection

Diffraction	Mean temperature: 100 K
Diffraction source	Source: SYNCHROTRON / Site: ALS / Beamline: 5.0.1 / Wavelength: 0.979 Å
Detector	Type: ADSC QUANTUM 315r / Detector: CCD / Date: Sep 27, 2015
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.979 Å / Relative weight: 1
Reflection	Resolution: 2.1→25 Å / Num. obs: 51362 / % possible obs: 99.6 % / Redundancy: 6.8 % / R_merge(I) obs: 0.078 / Net I/σ(I): 20.5
Reflection shell	Resolution: 2.1→2.2 Å / Redundancy: 5.4 % / R_merge(I) obs: 0.424 / Mean I/σ(I) obs: 3.5 / Num. unique obs: 5038 / % possible all: 96.8

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Processing

Software

Name	Version	Classification
PHENIX	1.9_1692	refinement
HKL-2000		data reduction
HKL-2000		data scaling
AutoSol		phasing

Refinement

Method to determine structure:

SIRAS / Resolution: 2.1→24.83 Å / SU ML: 0.25 / Cross valid method: FREE R-VALUE / σ(F): 1.33 / Phase error: 23.03

	R_factor	Num. reflection	% reflection
R_free	0.2203	1861	3.9 %
R_work	0.1665	-	-
obs	0.1686	47760	99.56 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å

Refinement step

Cycle: LAST / Resolution: 2.1→24.83 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	5636	0	0	419	6055

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.012	5727
X-RAY DIFFRACTION	f_angle_d	1.299	7733
X-RAY DIFFRACTION	f_dihedral_angle_d	15.391	2151
X-RAY DIFFRACTION	f_chiral_restr	0.056	926
X-RAY DIFFRACTION	f_plane_restr	0.005	977

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
2.0979-2.1546	0.2966	137	0.215	3362	X-RAY DIFFRACTION	96
2.1546-2.2179	0.245	141	0.1995	3507	X-RAY DIFFRACTION	100
2.2179-2.2895	0.2691	142	0.1944	3498	X-RAY DIFFRACTION	100
2.2895-2.3712	0.3093	143	0.1947	3534	X-RAY DIFFRACTION	100
2.3712-2.4661	0.2697	143	0.1901	3522	X-RAY DIFFRACTION	100
2.4661-2.5782	0.2344	144	0.1768	3545	X-RAY DIFFRACTION	100
2.5782-2.714	0.26	143	0.1803	3537	X-RAY DIFFRACTION	100
2.714-2.8838	0.2599	144	0.1885	3533	X-RAY DIFFRACTION	100
2.8838-3.1061	0.2491	143	0.1872	3546	X-RAY DIFFRACTION	100
3.1061-3.4179	0.2449	144	0.1745	3553	X-RAY DIFFRACTION	100
3.4179-3.9109	0.203	143	0.1534	3538	X-RAY DIFFRACTION	100
3.9109-4.921	0.1645	146	0.1241	3587	X-RAY DIFFRACTION	100
4.921-24.8319	0.1579	148	0.1493	3637	X-RAY DIFFRACTION	100

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	3.5022	-0.3923	-0.3563	3.0025	2.7406	3.8725	-0.4211	0.3307	-0.9623	0.2762	0.2673	0.7247	0.6465	-0.1129	0.1818	0.3392	-0.1234	0.0744	0.3491	-0.0352	0.4743	10.8935	58.6607	63.58
2	5.1699	0.0388	3.5285	7.2115	-1.2009	2.906	0.2094	-0.7331	0.2705	0.6762	0.0249	0.6304	-0.3298	-0.7954	-0.2051	0.2645	-0.0386	0.1165	0.3361	0.0035	0.2593	11.1132	71.659	74.3172
3	3.4902	-3.6809	4.1773	4.2373	-5.6448	9.3175	0.1116	-0.8363	1.0262	0.3818	0.0033	0.0621	-0.7524	0.7058	0.1166	0.2142	-0.0786	0.0262	0.3641	-0.0716	0.3302	18.7139	74.9567	75.8176
4	4.185	1.1815	3.143	3.2147	1.8383	3.311	0.2864	-0.2589	-0.1824	-0.2367	-0.0855	0.8918	-0.1227	-1.1532	0.1083	0.2358	0.0264	0.0041	0.2971	0.0021	0.3505	9.547	78.507	61.4166
5	3.4375	-2.759	-1.8275	3.2283	-0.3425	4.0635	0.1105	0.0848	-0.0921	0.0263	0.0004	0.2029	-0.1321	-0.1703	-0.1259	0.1838	-0.0328	-0.001	0.1582	0.0105	0.179	18.7582	72.109	62.9982
6	3.5116	-0.1675	-0.578	4.4586	2.0975	5.2112	0.0289	-0.2918	-0.5276	0.411	-0.2886	0.3585	0.6048	-0.2882	0.104	0.3132	-0.0437	0.0666	0.2275	0.0081	0.2447	17.8205	61.7274	69.1724
7	9.7553	-4.0977	8.2438	1.7374	-3.5283	7.3768	-0.0941	2.1861	-2.3196	-1.5812	0.5901	2.2249	1.8463	1.2028	-0.478	0.8929	-0.1096	-0.0725	0.7132	-0.2462	1.1528	4.6548	47.7914	57.5802
8	2.5167	1.6444	-2.0583	3.5614	-1.7334	3.8088	-0.2248	0.181	-0.1934	-0.306	0.1389	-0.0272	0.1056	0.0961	0.0884	0.2611	-0.0159	-0.0085	0.1676	-0.0585	0.184	26.8199	66.9537	56.3373
9	8.6148	1.6129	0.9501	3.4372	0.7098	7.7517	0.1395	0.0522	-0.1737	0.0005	-0.0383	-0.2338	0.0107	0.6481	-0.0654	0.1812	0.0411	-0.0011	0.2109	-0.0373	0.15	35.2985	60.0932	48.9125
10	8.8246	6.9836	-3.9203	5.9116	-3.8819	3.8664	0.2459	0.0809	1.8268	-0.9137	0.025	0.855	0.2885	0.6357	-0.358	0.9346	-0.3753	0.1512	0.6152	-0.0824	0.5716	36.7321	79.1585	51.6967
11	8.402	1.0306	-1.3909	5.3926	-0.1302	4.15	-0.1025	-0.2276	-0.4153	0.3725	-0.0361	-0.19	0.1296	0.2316	0.1289	0.2213	0.0311	-0.0092	0.1754	-0.0404	0.1573	32.1924	62.1295	58.8592
12	9.6887	2.3155	0.9453	4.096	-4.8603	7.3826	0.2195	0.2164	0.4413	-0.1808	-0.3639	-0.1863	-0.1943	0.2228	0.1587	0.3141	0.0346	0.0663	0.283	0.0071	0.3236	42.6417	62.9621	27.4767
13	9.176	-1.2966	-0.6344	2.2921	2.277	2.3393	0.1581	1.7009	0.8043	-1.5145	-0.4236	-0.828	-0.6455	-0.2217	0.2794	0.6656	0.084	0.0237	0.8397	0.211	0.4914	36.1194	69.7182	13.2305
14	5.4541	2.8541	3.1963	4.8616	-1.4571	5.029	-0.4512	2.286	0.5571	-2.0361	-0.3047	0.7859	0.7114	-0.3479	0.5479	0.7748	0.1075	0.0557	1.4266	0.1936	0.6953	27.0598	70.6044	12.276
15	5.3627	3.1805	3.2826	6.5136	5.0825	4.1523	-0.8796	-0.3908	0.8162	0.1684	0.7234	-0.1262	-0.355	-0.2616	0.206	0.6937	0.0523	-0.0385	0.6221	0.2119	0.6801	32.1659	80.2291	24.1332
16	7.5131	0.7443	-0.255	7.9941	0.0185	3.3973	0.2264	1.1334	1.7761	-0.8178	0.05	1.1927	-1.1261	-0.7866	-0.1544	0.5468	0.1924	0.092	0.5729	0.2819	0.7587	28.2864	72.1349	22.9252
17	6.1788	1.1307	-1.9526	5.7469	-0.8537	3.2112	-0.0572	0.8876	0.3931	-0.4692	0.0742	0.2509	-0.3147	-0.2062	-0.0194	0.3229	0.0533	0.0209	0.3273	0.0916	0.1969	33.6315	62.6194	23.8641
18	7.8228	1.0144	-2.155	3.1969	0.1924	3.7817	0.0108	-0.2358	0.0125	0.12	0.0078	0.0981	-0.107	0.1684	-0.0411	0.3327	0.0296	0.0392	0.2158	0.0638	0.2219	32.9864	61.7928	33.8143
19	3.5315	-3.3742	-2.2804	3.8086	2.2053	2.4145	-0.131	0.5347	-0.3172	0.0202	-0.1923	1.2777	-0.4892	-0.9772	0.3392	0.3502	0.0303	0.0234	0.3863	-0.0497	0.4115	14.187	53.93	42.2759
20	3.0889	0.5927	-0.6623	2.493	0.7648	4.5617	-0.0237	0.1751	0.2787	-0.1515	-0.0573	0.2073	-0.2684	-0.5984	0.0346	0.2241	0.0586	-0.0189	0.2158	0.0226	0.2346	21.5433	57.1509	36.6686
21	5.6609	-3.5233	-1.1829	2.5394	1.3176	2.3889	0.1219	0.5667	0.1286	0.1947	-0.2498	0.4165	-0.0511	-0.1965	0.112	0.235	-0.0222	0.0685	0.1579	0.0525	0.301	-10.4719	59.5978	17.277
22	5.0944	-2.9226	5.3197	3.2702	-1.2921	8.0882	-0.3639	-1.1778	-0.6424	1.417	0.2901	0.8367	-0.4513	-0.4598	-0.0022	0.5331	0.0126	0.086	0.3657	-0.0003	0.304	-6.9768	72.0128	28.0571
23	6.7434	-6.1057	5.7491	5.5476	-5.204	4.913	-0.0522	-0.1858	0.9038	0.9688	-0.0117	-1.2985	0.278	0.898	0.0397	0.3715	0.0468	-0.0336	0.453	-0.0162	0.4397	0.6731	77.1541	27.0976
24	2.0715	-0.7654	1.525	5.9067	-1.2043	7.151	-0.0825	-0.0654	0.1419	-0.0756	0.3082	0.4683	-0.0605	-0.2574	-0.2338	0.2572	0.0386	0.0346	0.1758	0.0293	0.262	-6.7781	78.5014	16.3325
25	7.0249	6.5686	0.6293	8.3976	0.8587	2.8663	-0.8984	-0.463	0.4353	-0.0932	0.3699	0.266	-0.1182	-0.011	0.2798	0.212	0.0426	-0.0218	0.1683	0.0183	0.163	-1.0616	73.6826	15.8023
26	7.5697	5.1222	-3.4421	5.6319	-0.5152	3.3678	-0.0486	-0.1449	1.0423	-0.0229	0.0551	0.3372	0.1487	0.0377	-0.0334	0.2574	0.0615	-0.0324	0.1461	-0.0074	0.1366	-1.1814	68.3553	13.5607
27	2.4106	0.7725	-1.8967	4.5413	-1.1423	4.3683	-0.3204	-0.5265	-0.2114	0.2959	0.1919	0.2615	0.4211	-0.0618	0.1204	0.3556	0.0987	0.0453	0.2736	0.0698	0.1989	-2.3784	61.8845	21.581
28	7.4244	2.0316	-4.7908	5.7125	-1.619	5.1413	-0.3893	0.2639	-0.3395	-0.1201	0.3254	-0.0911	0.4909	-0.1012	0.0537	0.2541	0.0028	-0.0244	0.1134	0.0299	0.1306	-1.7675	64.7313	11.061
29	3.135	-0.9083	-0.4782	3.7597	-4.7907	7.0217	-0.8224	-0.9167	2.0064	-0.2509	0.1369	-0.8804	-1.9968	1.5319	0.6482	0.3448	-0.3503	0.1373	0.9569	-0.2893	1.202	22.4318	71.3917	2.627
30	8.0384	-2.6923	2.2714	2.0417	0.2669	8.4195	-0.276	0.427	0.508	0.1306	0.3758	-0.6443	-0.32	0.9883	0.0202	0.2402	-0.0176	-0.0032	0.3769	-0.0571	0.3314	17.2592	62.1555	-1.2689
31	2.3742	0.1237	2.9079	1.1461	0.6905	4.8434	0.1923	-0.8996	-1.161	1.0502	0.2654	-0.7497	1.2109	0.459	-0.1257	0.4598	0.0946	-0.1232	0.3974	0.0255	0.5153	12.1379	49.3055	2.6737
32	7.0348	1.0726	0.5158	2.383	0.9541	5.8022	-0.0319	0.0202	0.253	-0.0878	0.1807	0.1039	-0.3226	0.4907	-0.0374	0.164	-0.0179	0.0162	0.1244	-0.0156	0.1511	8.099	63.0088	-1.2328
33	5.5547	1.4212	-1.8198	5.6513	0.1608	4.5502	-0.1203	-0.337	-0.2353	0.1992	0.1155	-0.1725	0.3031	0.5641	0.0131	0.2377	0.1074	-0.0332	0.2218	-0.0294	0.1626	8.9956	60.4136	10.22
34	4.6395	-2.1173	3.376	5.2809	-2.0126	4.5873	-0.1904	0.5381	0.264	-0.3838	-0.1876	-0.273	-0.1223	0.2707	0.2405	0.2547	-0.0599	0.0399	0.2794	0.0453	0.2247	8.7991	69.931	-30.4665
35	7.1629	2.3992	5.9402	5.1951	2.6177	6.3039	-0.7718	-0.4394	0.9218	0.6628	0.0629	-0.0499	-0.4877	-0.6782	0.4801	0.4323	-0.0015	-0.0826	0.2298	-0.025	0.3725	4.0487	80.456	-22.5731
36	2.8992	1.7381	2.3662	8.9311	0.9933	9.2037	-0.2461	-0.5231	0.6156	-0.6466	0.0963	0.6152	-0.5149	-1.018	0.0698	0.2759	-0.0162	-0.025	0.2654	0.0482	0.2145	0.8997	73.7055	-24.1983
37	7.2754	-0.5106	-0.3165	3.9506	0.7772	4.7542	-0.1011	0.2479	-0.2302	-0.2525	0.1167	-0.0994	0.2314	-0.2199	-0.0227	0.2316	-0.0476	0.0076	0.1629	0.039	0.129	6.684	63.662	-25.0876
38	4.9749	1.3449	-1.6059	1.52	-0.2846	2.3554	-0.3264	-0.601	-0.6671	0.0191	0.1109	-0.0977	0.0659	-0.0088	0.1771	0.2083	0.0024	0.021	0.1785	0.0593	0.2272	7.097	61.5741	-15.227
39	5.0897	0.2759	-0.05	6.0719	3.0176	6.695	-0.0902	-0.0889	-0.0734	0.1342	0.0977	0.6298	0.1348	-0.5964	-0.0441	0.2151	-0.0372	0.0278	0.2368	0.0853	0.177	-6.0464	53.4297	-4.2515
40	2.9999	-0.8393	0.3341	4.538	-0.1234	3.214	-0.0702	0.0354	0.168	-0.031	0.0938	0.38	-0.1171	-0.5259	-0.0042	0.1981	-0.004	-0.0055	0.2285	0.0366	0.1891	-4.7957	58.0896	-13.9477

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 582 through 590 )
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 591 through 600 )
3	X-RAY DIFFRACTION	3	chain 'A' and (resid 601 through 606 )
4	X-RAY DIFFRACTION	4	chain 'A' and (resid 607 through 614 )
5	X-RAY DIFFRACTION	5	chain 'A' and (resid 615 through 640 )
6	X-RAY DIFFRACTION	6	chain 'A' and (resid 641 through 658 )
7	X-RAY DIFFRACTION	7	chain 'B' and (resid 493 through 502 )
8	X-RAY DIFFRACTION	8	chain 'B' and (resid 503 through 522 )
9	X-RAY DIFFRACTION	9	chain 'B' and (resid 523 through 560 )
10	X-RAY DIFFRACTION	10	chain 'B' and (resid 561 through 568 )
11	X-RAY DIFFRACTION	11	chain 'B' and (resid 569 through 597 )
12	X-RAY DIFFRACTION	12	chain 'C' and (resid 582 through 590 )
13	X-RAY DIFFRACTION	13	chain 'C' and (resid 591 through 601 )
14	X-RAY DIFFRACTION	14	chain 'C' and (resid 602 through 606 )
15	X-RAY DIFFRACTION	15	chain 'C' and (resid 607 through 613 )
16	X-RAY DIFFRACTION	16	chain 'C' and (resid 614 through 629 )
17	X-RAY DIFFRACTION	17	chain 'C' and (resid 630 through 658 )
18	X-RAY DIFFRACTION	18	chain 'D' and (resid 493 through 522 )
19	X-RAY DIFFRACTION	19	chain 'D' and (resid 523 through 537 )
20	X-RAY DIFFRACTION	20	chain 'D' and (resid 538 through 596 )
21	X-RAY DIFFRACTION	21	chain 'E' and (resid 582 through 590 )
22	X-RAY DIFFRACTION	22	chain 'E' and (resid 591 through 601 )
23	X-RAY DIFFRACTION	23	chain 'E' and (resid 602 through 606 )
24	X-RAY DIFFRACTION	24	chain 'E' and (resid 607 through 620 )
25	X-RAY DIFFRACTION	25	chain 'E' and (resid 621 through 629 )
26	X-RAY DIFFRACTION	26	chain 'E' and (resid 630 through 640 )
27	X-RAY DIFFRACTION	27	chain 'E' and (resid 641 through 658 )
28	X-RAY DIFFRACTION	28	chain 'F' and (resid 504 through 516 )
29	X-RAY DIFFRACTION	29	chain 'F' and (resid 517 through 522 )
30	X-RAY DIFFRACTION	30	chain 'F' and (resid 523 through 537 )
31	X-RAY DIFFRACTION	31	chain 'F' and (resid 538 through 542 )
32	X-RAY DIFFRACTION	32	chain 'F' and (resid 543 through 570 )
33	X-RAY DIFFRACTION	33	chain 'F' and (resid 571 through 596 )
34	X-RAY DIFFRACTION	34	chain 'G' and (resid 582 through 605 )
35	X-RAY DIFFRACTION	35	chain 'G' and (resid 606 through 613 )
36	X-RAY DIFFRACTION	36	chain 'G' and (resid 614 through 629 )
37	X-RAY DIFFRACTION	37	chain 'G' and (resid 630 through 658 )
38	X-RAY DIFFRACTION	38	chain 'H' and (resid 493 through 522 )
39	X-RAY DIFFRACTION	39	chain 'H' and (resid 523 through 550 )
40	X-RAY DIFFRACTION	40	chain 'H' and (resid 551 through 597 )

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