PDB-5v6d: Crystal structure of nucleoside diphosphate kinase from Neisseria...

Basic information

• Entry: Database: PDB / ID: 5v6d
• Title: Crystal structure of nucleoside diphosphate kinase from Neisseria gonorrhoeae in complex with citrate
• Components: Nucleoside diphosphate kinase
• Keywords: TRANSFERASE / SSGCID / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / nucleoside diphosphate kinase

Function / homology

Function:

nucleoside-diphosphate kinase / UTP biosynthetic process / CTP biosynthetic process / GTP biosynthetic process / nucleoside diphosphate kinase activity / ATP binding / metal ion binding / cytoplasm

Domain/homology:

Nucleoside diphosphate kinase (NDPK)-like domain profile. / Nucleoside diphosphate kinase-like domain / Nucleoside diphosphate kinase, active site / Nucleoside diphosphate kinase (NDPK) active site signature. / Nucleoside diphosphate kinase / Nucleoside diphosphate kinase-like domain / Nucleoside diphosphate kinase / NDK / Nucleoside diphosphate kinase-like domain superfamily / Alpha-Beta Plaits / 2-Layer Sandwich / Alpha Beta

Component:

CITRIC ACID / Nucleoside diphosphate kinase

• Biological species: Neisseria gonorrhoeae NCCP11945 (bacteria)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.85 Å
• Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)
• Citation: Journal: To be Published; Title: Crystal structure of nucleoside diphosphate kinase from Neisseria gonorrhoeae in complex with citrate; Authors: Abendroth, J. / Mayclin, S.J. / Lorimer, D.D. / Edwards, T.E.

History

Deposition	Mar 16, 2017	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Apr 19, 2017	Provider: repository / Type: Initial release
Revision 1.1	Oct 4, 2023	Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

Assembly

Deposited unit

A: Nucleoside diphosphate kinase

B: Nucleoside diphosphate kinase

C: Nucleoside diphosphate kinase

D: Nucleoside diphosphate kinase

E: Nucleoside diphosphate kinase

F: Nucleoside diphosphate kinase

G: Nucleoside diphosphate kinase

H: Nucleoside diphosphate kinase

I: Nucleoside diphosphate kinase

J: Nucleoside diphosphate kinase

K: Nucleoside diphosphate kinase

L: Nucleoside diphosphate kinase

M: Nucleoside diphosphate kinase

N: Nucleoside diphosphate kinase

O: Nucleoside diphosphate kinase

P: Nucleoside diphosphate kinase

hetero molecules

Summary:

• 268 kDa, 16 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	268,261	54
Polymers	263,822	16
Non-polymers	4,439	38
Water	39,975	2219

1

A: Nucleoside diphosphate kinase

B: Nucleoside diphosphate kinase

hetero molecules

Summary:

• defined by author&software
• Evidence: gel filtration
• 33.5 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	33,548	7
Polymers	32,978	2
Non-polymers	570	5
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	3090 Å2
ΔGint	-1 kcal/mol
Surface area	12380 Å2
Method	PISA

2

C: Nucleoside diphosphate kinase

D: Nucleoside diphosphate kinase

hetero molecules

Summary:

• defined by author&software
• 33.5 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	33,548	7
Polymers	32,978	2
Non-polymers	570	5
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	3200 Å2
ΔGint	-0 kcal/mol
Surface area	12270 Å2
Method	PISA

3

E: Nucleoside diphosphate kinase

F: Nucleoside diphosphate kinase

hetero molecules

Summary:

• defined by author&software
• 33.5 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	33,486	6
Polymers	32,978	2
Non-polymers	508	4
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	3190 Å2
ΔGint	-2 kcal/mol
Surface area	12390 Å2
Method	PISA

4

G: Nucleoside diphosphate kinase

H: Nucleoside diphosphate kinase

hetero molecules

Summary:

• defined by author&software
• 33.6 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	33,610	8
Polymers	32,978	2
Non-polymers	633	6
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	2990 Å2
ΔGint	-5 kcal/mol
Surface area	12590 Å2
Method	PISA

5

I: Nucleoside diphosphate kinase

J: Nucleoside diphosphate kinase

hetero molecules

Summary:

• defined by author&software
• 33.5 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	33,486	6
Polymers	32,978	2
Non-polymers	508	4
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	3060 Å2
ΔGint	-2 kcal/mol
Surface area	12630 Å2
Method	PISA

6

K: Nucleoside diphosphate kinase

L: Nucleoside diphosphate kinase

hetero molecules

Summary:

• defined by author&software
• 33.5 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	33,548	7
Polymers	32,978	2
Non-polymers	570	5
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	3260 Å2
ΔGint	-0 kcal/mol
Surface area	12410 Å2
Method	PISA

7

M: Nucleoside diphosphate kinase

N: Nucleoside diphosphate kinase

hetero molecules

Summary:

• defined by author&software
• 33.5 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	33,548	7
Polymers	32,978	2
Non-polymers	570	5
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	3190 Å2
ΔGint	1 kcal/mol
Surface area	12470 Å2
Method	PISA

8

O: Nucleoside diphosphate kinase

P: Nucleoside diphosphate kinase

hetero molecules

Summary:

• defined by author&software
• 33.5 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	33,486	6
Polymers	32,978	2
Non-polymers	508	4
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	2980 Å2
ΔGint	-4 kcal/mol
Surface area	12210 Å2
Method	PISA

Unit cell

Length a, b, c (Å)	57.240, 112.350, 112.870
Angle α, β, γ (deg.)	104.310, 98.500, 105.390
Int Tables number	1
Space group name H-M	P1

Components

#1: Protein

A B C D E F G H I J K L M N O P
Nucleoside diphosphate kinase / NDP kinase / Nucleoside-2-P kinase

Details:

Mass: 16488.852 Da / Num. of mol.: 16
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Neisseria gonorrhoeae NCCP11945 (bacteria)
Gene: ndk, NGK_1320 / Plasmid: NegoA.00438.a.B1 / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: B4RMG0, nucleoside-diphosphate kinase

#2: Chemical

A-201 B-201 C-201 D-201 E-201 F-201 G-201 H-202 I-201 J-201 K-201 L-201 M-201 N-201 O-201 P-201
ChemComp-CIT / CITRIC ACID

Details:

Mass: 192.124 Da / Num. of mol.: 16 / Source method: obtained synthetically / Formula: C₆H₈O₇

#3: Chemical

A-202 A-203 B-202 C-202 C-203 D-202 E-202 F-202 G-202 H-201 H-203 H-204 I-202 J-202 K-202 K-203 L-202 M-202 M-203 N-202 ...
ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL

Details:

Mass: 62.068 Da / Num. of mol.: 22 / Source method: obtained synthetically / Formula: C₂H₆O₂

#4: Water

ChemComp-HOH / water

Details:

Mass: 18.015 Da / Num. of mol.: 2219 / Source method: isolated from a natural source / Formula: H₂O

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 2.51 ų/Da / Density % sol: 51 %
• Crystal grow: Temperature: 290 K / Method: vapor diffusion, sitting drop / pH: 5 ; Details: 17.1 mg/mL NegoA.00438.a.B1.PW37901 + JCSG+ screen B9: 20% PEG6000, 100 mM sodium citrate tribasic, pH 5.0, cryoprotectant: 20% ethylene glycol in two steps, tray 2273617b9, puck mrl5-6

Data collection

• Diffraction: Mean temperature: 100 K
• Diffraction source: Source: SYNCHROTRON / Site: APS / Beamline: 21-ID-F / Wavelength: 0.97872 Å
• Detector: Type: MARMOSAIC 225 mm CCD / Detector: CCD / Date: Oct 26, 2016
• Radiation: Monochromator: diamond(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.97872 Å / Relative weight: 1
• Reflection: Resolution: 1.85→50 Å / Num. obs: 212120 / % possible obs: 97.1 % / Observed criterion σ(I): -3 / Redundancy: 2.972 % / B_iso Wilson estimate: 23.07 Ų / CC_1/2: 0.997 / R_merge(I) obs: 0.06 / R_rim(I) all: 0.074 / Χ²: 0.992 / Net I/σ(I): 11.92

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	Rmerge(I) obs	Mean I/σ(I) obs	Num. unique obs	CC1/2	Rrim(I) all	% possible all
1.85-1.9	2.985	0.517	2.6	15507	0.891	0.63	96.2
1.9-1.95	2.981	0.394	3.26	15188	0.926	0.482	96.4
1.95-2.01	2.985	0.316	4.04	14817	0.946	0.386	96.4
2.01-2.07	2.983	0.232	5.24	14329	0.969	0.284	96.6
2.07-2.14	2.989	0.194	6.1	13945	0.978	0.237	96.8
2.14-2.21	2.983	0.161	7.06	13553	0.982	0.198	96.7
2.21-2.29	2.98	0.122	8.65	13071	0.989	0.149	97
2.29-2.39	2.978	0.105	9.87	12590	0.99	0.129	97.1
2.39-2.49	2.98	0.093	10.88	12083	0.991	0.114	97.3
2.49-2.62	2.973	0.082	12.03	11599	0.992	0.101	97.5
2.62-2.76	2.971	0.068	14.2	10968	0.994	0.083	97.6
2.76-2.93	2.968	0.057	16.43	10416	0.995	0.07	97.6
2.93-3.13	2.965	0.05	18.8	9855	0.995	0.061	97.7
3.13-3.38	2.967	0.044	21.19	9139	0.996	0.054	97.9
3.38-3.7	2.954	0.038	23.73	8375	0.996	0.047	97.9
3.7-4.14	2.955	0.036	25.49	7636	0.996	0.045	97.9
4.14-4.78	2.953	0.035	26.93	6729	0.996	0.043	97.9
4.78-5.85	2.939	0.036	26.69	5645	0.996	0.044	97.9
5.85-8.27	2.932	0.035	27.25	4379	0.996	0.043	97.6
8.27-50	2.832	0.034	28.28	2296	0.996	0.043	94.2

Processing

Software

Name	Version	Classification
PHENIX		refinement
XSCALE		data scaling
PDB_EXTRACT	3.22	data extraction
XDS		data reduction
MOLREP		phasing

Refinement

Method to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB entry 3VGS

3vgs

Resolution: 1.85→44.089 Å / SU ML: 0.19 / Cross valid method: FREE R-VALUE / σ(F): 1.98 / Phase error: 22.37 / Stereochemistry target values: ML

	Rfactor	Num. reflection	% reflection
Rfree	0.1884	1974	0.93 %
Rwork	0.15	210063	-
obs	0.1504	212037	97.12 %

• Solvent computation: Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
• Displacement parameters: B_iso max: 112.95 Ų / B_iso mean: 33.5398 Ų / B_iso min: 11.02 Ų

Refinement step

Cycle: final / Resolution: 1.85→44.089 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	17051	0	296	2244	19591
Biso mean	-	-	37.96	39.73	-
Num. residues	-	-	-	-	2245

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.006	18124
X-RAY DIFFRACTION	f_angle_d	0.755	24620
X-RAY DIFFRACTION	f_chiral_restr	0.053	2822
X-RAY DIFFRACTION	f_plane_restr	0.005	3241
X-RAY DIFFRACTION	f_dihedral_angle_d	15.681	11147

LS refinement shell

Refine-ID: X-RAY DIFFRACTION / R_factor R_free error: 0 / Total num. of bins used: 14

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Num. reflection all	% reflection obs (%)
1.85-1.8963	0.3226	128	0.247	14805	14933	96
1.8963-1.9475	0.2966	136	0.2197	14867	15003	96
1.9475-2.0048	0.2549	164	0.2039	14934	15098	96
2.0048-2.0696	0.259	114	0.1798	14892	15006	97
2.0696-2.1435	0.2038	146	0.1686	14981	15127	97
2.1435-2.2293	0.1988	144	0.1556	14967	15111	97
2.2293-2.3308	0.1954	132	0.1481	15015	15147	97
2.3308-2.4537	0.2066	133	0.1503	15000	15133	97
2.4537-2.6074	0.2041	161	0.1599	15092	15253	98
2.6074-2.8087	0.2038	154	0.1543	15063	15217	98
2.8087-3.0913	0.179	137	0.1546	15073	15210	98
3.0913-3.5384	0.1972	154	0.1461	15168	15322	98
3.5384-4.4573	0.1445	138	0.1231	15161	15299	98
4.4573-44.1014	0.1437	133	0.1276	15045	15178	97

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	3.4402	-1.4904	0.1607	3.6542	2.3688	2.0295	0.0917	0.0239	-0.5721	0.3833	0.3954	-0.9133	0.248	0.3483	-0.3012	0.2966	0.0232	-0.0697	0.2546	-0.0963	0.5831	-5.0666	106.3045	71.9026
2	3.4208	1.3342	2.2176	2.3473	-2.016	6.0727	0.1749	-0.4435	0.0566	-0.0586	-0.1029	-0.9064	0.3447	1.0959	-0.1127	0.3374	0.0078	-0.1222	0.6451	-0.1746	0.7086	3.1515	120.8653	83.5542
3	2.7966	0.0507	0.2974	1.6618	-0.0324	2.916	-0.0807	-0.0115	-0.0506	-0.0065	0.4141	-0.89	-0.0009	0.4718	-0.2745	0.2439	0.0047	-0.0362	0.3178	-0.1238	0.6051	-1.2496	114.4554	76.3588
4	3.9724	-1.9564	-0.3707	1.8917	-0.4015	2.7349	-0.1734	-0.5521	-0.1862	0.5035	0.7807	-0.5543	0.0588	0.2321	0.2006	0.401	0.3059	-0.3613	0.5061	-0.0437	1.1722	0.896	100.1684	78.8396
5	5.0338	-0.4068	-0.7486	0.9838	0.6535	0.4871	0.009	-0.0337	0.4079	-0.0267	0.1491	-0.8259	0.0066	0.3933	-0.4811	0.5578	0.1803	-0.1721	0.533	-0.3905	1.7143	11.9122	102.7389	72.1303
6	3.4682	-0.2724	-0.8651	1.7747	1.6874	1.6414	0.0903	-0.1457	-0.638	0.3909	0.3355	-1.3747	0.4561	0.5355	-0.2296	0.3953	0.0599	-0.1931	0.4556	-0.1226	0.9474	1.4446	109.7021	78.8324
7	5.0551	-2.6728	-2.4339	6.5818	2.8196	6.3842	0.1792	-0.1605	-0.2884	0.5833	-0.2287	0.1132	0.5311	-0.0871	-0.024	0.4409	-0.0371	-0.1154	0.2072	0.0506	0.2773	-17.2113	108.4925	80.0833
8	2.6313	0.533	0.7631	2.6922	0.1319	1.0515	-0.0302	0.2648	-0.0388	-0.7235	0.2891	-0.5585	-0.305	0.2912	-0.2073	0.3887	-0.0504	0.1082	0.2076	-0.0468	0.2757	-13.2004	109.6907	61.7254
9	2.4372	0.8639	2.784	6.5179	-3.6908	6.732	0.1145	-0.1349	0.3685	0.2211	-0.36	0.7152	-0.5761	-0.327	0.1234	0.314	0.0438	-0.038	0.273	-0.1086	0.378	-30.3305	111.9907	69.6163
10	5.5303	1.6159	2.5511	3.8909	0.5585	5.6961	-0.1656	0.1585	-0.0487	-0.6152	-0.1124	0.5087	-0.4501	-0.5982	0.1674	0.3222	0.058	-0.0822	0.2404	-0.0629	0.2732	-33.0806	106.3955	62.6751
11	1.5819	-0.5641	-2.0534	0.2477	0.9243	3.4934	0.1921	0.0985	0.0539	-0.6662	0.1323	-0.5714	-0.5556	0.4177	-0.3333	0.4469	-0.0805	0.0797	0.2149	-0.0282	0.3221	-13.8341	114.9158	61.2091
12	1.3882	-0.3652	0.0975	4.9587	-1.9965	0.813	0.0065	0.4333	-0.0445	-0.9992	0.1204	-0.0393	-0.6572	0.3519	-0.104	0.8627	-0.1109	0.1231	0.3637	-0.0355	0.2483	-15.8972	112.0997	50.622
13	4.3744	-0.4241	-2.6099	9.8414	3.0768	4.7737	0.0171	0.3825	-0.3272	-1.3655	0.1529	0.202	0.3148	-0.099	-0.2609	0.8444	0.0158	0.0129	0.3597	0.0151	0.3239	-19.7493	99.5863	49.3364
14	1.3265	0.611	0.0236	1.5265	-0.4474	0.6201	0.0275	0.1405	0.0108	-1.0915	-0.0628	0.0521	-0.4226	-0.0119	0.0377	0.526	0.0308	-0.0476	0.201	-0.0163	0.225	-22.5859	110.2413	57.905
15	5.2419	-4.03	-2.8657	7.6473	4.3963	6.7417	-0.003	-0.3127	0.1666	-1.0676	0.1626	-1.086	-0.4988	0.4543	-0.1988	0.4641	-0.0419	0.0789	0.2254	-0.0185	0.3571	-12.5496	123.2234	67.252
16	7.2684	0.3144	-0.5397	3.3383	0.6825	7.1607	-0.0964	0.2926	0.6755	-0.0007	0.2155	-0.2147	-0.465	0.1529	-0.1023	0.2116	0.0247	-0.0587	0.1675	-0.0049	0.2134	-4.1902	80.765	64.3149
17	4.0255	-3.3628	-1.2052	3.4627	0.4342	2.5612	-0.2	-0.5121	-0.0088	0.7566	0.1588	-0.0868	0.2466	0.0437	0.0116	0.4537	0.0822	-0.0406	0.2626	0.038	0.1643	-11.1896	71.294	78.3768
18	6.5608	2.3533	1.4606	5.3641	-4.948	7.2715	-0.2322	-0.2339	0.3643	0.5194	0.1919	0.0116	-0.4319	0.0661	0.0585	0.3704	0.1157	-0.0698	0.2356	-0.0348	0.2129	-10.3159	84.1346	75.0721
19	3.8587	1.1546	-0.2183	8.8312	-2.1028	3.9605	-0.1184	-0.0791	0.1267	0.1845	0.2259	-0.0964	-0.1195	0.0012	-0.1148	0.1778	0.0328	-0.0242	0.1524	0.0144	0.124	-12.0735	79.0421	65.0929
20	7.1931	1.9106	-2.2468	3.6839	-0.4197	3.2588	-0.0378	0.0631	-0.189	-0.0054	0.1751	-0.1192	0.5251	0.2082	-0.1333	0.3334	0.0759	-0.0612	0.2398	-0.0047	0.1818	-5.3424	62.1569	64.1118
21	5.2224	-1.2973	3.0899	5.3438	-3.5548	5.438	-0.0328	-0.0159	-0.1592	0.4358	-0.1041	-1.0154	0.3387	1.3783	0.1088	0.3369	0.1575	-0.1157	0.4866	-0.0208	0.4097	6.8649	62.9582	68.5866
22	8.9505	-2.0623	0.3797	2.499	-0.8803	2.8548	-0.1778	-0.2819	-0.3262	0.5461	0.1821	-0.1123	0.5401	0.343	-0.0371	0.4082	0.1034	-0.0793	0.2681	0.0177	0.191	-3.9334	61.9889	72.4249
23	5.0483	5.27	-1.5618	8.3881	-2.266	3.4414	-0.1799	-0.0009	0.33	-0.0853	0.272	0.2432	-0.1094	0.0242	-0.0389	0.2485	0.0362	-0.0717	0.2048	0.0054	0.1791	-7.1849	80.8121	65.8193
24	5.3115	-1.7528	-1.1905	5.1637	-3.4073	3.4756	-0.0192	-0.0045	0.3594	0.2115	0.2121	-0.3595	0.0589	0.4481	-0.2311	0.2947	-0.0048	-0.1599	0.2832	-0.0563	0.3171	0.9509	83.1198	71.2537
25	3.8456	1.5417	2.2733	2.2638	-1.4074	4.6181	-0.4064	-0.7132	0.5225	0.8784	0.1505	-0.6254	-0.1179	0.6436	0.2768	0.4537	0.1261	-0.179	0.4631	-0.0419	0.3089	3.3177	78.5132	82.5773
26	0.639	-0.2938	0.3351	0.6872	-0.3183	1.7621	-0.0731	-0.1259	0.0207	0.3422	0.1213	-0.1997	-0.0188	0.2055	-0.0089	0.2841	0.0556	-0.0909	0.2453	0.0038	0.1982	-1.1112	74.2908	70.2398
27	2.572	-3.0479	0.0996	7.7649	3.569	3.8954	-0.02	-0.0016	0.0911	-0.5145	0.0101	0.251	-1.1146	-0.2277	0.011	0.3475	0.0226	-0.0382	0.2053	0.0275	0.1826	-12.2966	80.6119	56.4778
28	2.9477	0.2573	0.1757	3.1979	0.2798	2.0823	-0.1597	-0.3215	0.0197	0.4308	-0.0368	0.1694	0.067	-0.1374	0.185	0.271	0.0525	0.0188	0.1883	0.0061	0.153	-22.492	80.1008	72.4548
29	4.2464	-0.6551	-0.0198	3.5852	-1.9324	4.1282	0.1214	0.3466	0.1041	-0.5506	-0.2911	0.6212	0.0855	-0.1795	0.2205	0.2711	0.0747	-0.1038	0.2267	-0.0594	0.2914	-29.3559	82.1653	54.5693
30	2.2075	-2.0083	1.5696	3.5167	-2.7997	2.2291	-0.0543	-0.3074	0.5573	0.0851	-0.206	1.4454	-0.4977	-0.9183	-0.1643	0.3541	0.1814	-0.1314	0.5009	-0.1773	0.8052	-40.7747	87.4147	59.3322
31	2.7386	-0.2926	-0.0013	3.6396	-0.5696	3.2953	-0.086	0.0842	0.1121	-0.0969	-0.2519	0.3267	-0.1093	-0.2045	0.2592	0.1814	0.054	-0.0288	0.1775	-0.0478	0.1974	-27.2001	83.4483	63.3067
32	5.8873	4.0712	1.423	3.33	-0.0012	2.9598	-0.1065	-0.8323	-0.3005	0.4291	-0.1808	0.8389	-0.3436	-0.8988	0.2951	0.3541	0.0573	0.1467	0.3767	-0.0121	0.3348	-32.5232	79.1928	77.7576
33	3.1981	-1.5424	0.5299	8.1094	1.9096	3.2646	-0.4917	-0.5591	0.8574	0.7664	0.1683	0.5305	-1.3389	-0.0179	0.2878	0.6698	0.1086	0.0618	0.4166	-0.0767	0.4183	-32.2907	92.653	78.5464
34	1.5351	0.0682	0.5238	4.4396	2.0051	2.3237	-0.0426	-0.1088	0.0099	0.2345	-0.2698	0.618	-0.0904	-0.2853	0.2903	0.1909	0.0444	0.0294	0.2133	-0.0312	0.2838	-31.2417	82.7873	68.4629
35	5.8825	0.4673	3.6525	6.2005	3.2432	3.665	0.1772	-0.1549	-0.1701	0.5306	-0.0847	-0.0412	0.8004	-0.275	-0.1032	0.2811	-0.0026	0.046	0.2128	0.0378	0.2205	-21.9616	66.2158	66.7755
36	2.3924	-0.4264	-1.0473	2.5294	-0.0028	3.0667	-0.0743	0.1529	-0.0187	-0.1868	-0.132	0.3502	0.0144	-0.2537	0.1594	0.1253	-0.0107	-0.0308	0.1445	-0.0097	0.1985	-23.9136	55.1107	43.011
37	9.1988	-1.3959	3.4701	4.6547	-0.5927	3.9358	-0.1999	0.1085	0.2017	-0.1754	-0.0959	0.4896	-0.1628	-0.3138	0.3014	0.1179	0.0173	-0.0215	0.1707	0.0012	0.1912	-24.6527	62.8322	46.1357
38	4.5027	2.8207	0.5921	6.699	-1.3831	4.6176	0.0552	-0.2355	0.0597	0.7772	-0.1411	0.1361	0.0301	-0.2534	0.0749	0.3335	0.0304	0.0394	0.1665	0.0237	0.1741	-19.4624	54.5313	62.2138
39	0.4767	-1.1988	0.6507	3.0959	-1.6712	0.9017	-0.4163	-0.411	-0.8303	0.5339	-0.0504	0.965	1.3503	-0.6732	0.3012	0.5417	-0.1217	0.2572	0.4075	0.0091	0.5367	-27.3875	44.2882	63.2256
40	3.9197	-0.7261	0.7401	3.0327	0.189	2.6804	-0.1183	-0.0609	-0.0356	0.3171	-0.1403	0.303	0.1235	-0.1281	0.1396	0.1456	-0.0114	0.0543	0.1355	-0.0134	0.1659	-22.6644	53.3576	53.0024
41	6.4381	-3.659	-1.7761	2.0806	1.0545	4.346	0.0868	0.227	-0.2751	0.0578	-0.1504	0.8213	0.6553	-0.5393	-0.0625	0.1677	-0.0776	-0.0267	0.2648	-0.0363	0.4831	-34.5217	51.7484	44.606
42	5.7658	-1.3165	1.8978	8.3182	1.8513	2.6902	0.1051	0.2601	-1.3889	-0.2037	-0.0846	0.5049	1.3278	-0.1074	0.01	0.4085	-0.0777	-0.0785	0.3282	-0.0526	0.5456	-28.5928	40.3793	42.4417
43	0.708	-0.5029	-0.5716	2.1708	1.144	1.8684	0.015	0.0049	-0.1838	0.1009	-0.1528	0.5097	0.0139	-0.2909	0.151	0.1345	-0.0277	0.0511	0.1838	0.0057	0.281	-27.7679	51.2016	51.3343
44	2.1034	0.9076	-1.7099	3.7902	3.7576	8.6015	-0.0746	0.1284	0.1409	-0.4654	-0.4398	0.5823	-0.6262	-0.3171	0.4241	0.2205	0.0762	-0.0384	0.2597	-0.0214	0.285	-27.8952	70.1689	50.2994
45	6.4208	-0.4797	2.2172	5.4608	-0.6594	5.598	-0.08	-0.1281	-0.3989	-0.1654	0.1262	-0.682	0.2276	0.5923	-0.0751	0.1671	0.0235	0.027	0.2191	0.0216	0.2189	-4.9291	65.1626	41.1425
46	4.5741	1.2333	1.3504	5.7766	0.1818	2.8342	-0.0582	0.0549	0.022	-0.5979	-0.0534	0.5736	-0.088	-0.124	0.0533	0.2591	0.0353	-0.1044	0.2141	0.0173	0.2026	-23.6353	69.2225	34.3212
47	9.8747	-5.3522	-0.5864	3.8239	-1.8715	5.4476	0.0401	0.2693	-0.2653	-0.573	-0.1402	0.0905	0.2037	0.0975	0.1271	0.2569	-0.0015	-0.0209	0.1627	0.0101	0.1722	-15.1844	58.9715	34.8588
48	7.5784	-3.4027	-0.3482	5.2344	0.4377	5.2511	-0.1663	-0.1702	0.0978	-0.0525	0.2062	-0.0441	0.0242	0.1055	-0.0288	0.1086	-0.0254	-0.0168	0.1229	0.0371	0.1373	-13.5312	63.4045	44.4937
49	8.0122	1.1782	-2.4962	7.021	0.3206	3.2009	0.0154	0.0001	0.1434	0.3995	0.0265	-0.031	-0.7323	0.0686	-0.0182	0.3275	0.0118	-0.0684	0.1863	0.0258	0.1724	-16.5119	81.7044	44.5099
50	4.9524	-1.4935	0.4535	8.0809	-6.6407	5.5865	-0.3814	0.8672	0.7557	-0.9372	0.0161	-0.5584	-0.8443	0.5638	0.3765	0.5699	-0.1067	-0.0489	0.3317	0.0937	0.3061	-9.7356	86.4522	34.6056
51	3.0185	3.4649	-3.2246	5.2379	-1.9299	5.9307	-0.1899	0.1766	0.5101	-0.5428	0.2936	0.4194	-0.5751	-0.2699	-0.0914	0.4084	0.0323	-0.0858	0.2172	0.0623	0.248	-18.787	82.8964	36.2653
52	8.3832	-5.6044	1.5973	4.0184	-1.0926	3.5688	-0.1654	-0.0151	0.0709	0.0479	0.1348	-0.1113	-0.1372	-0.016	0.0105	0.1267	-0.0132	-0.0048	0.1425	0.0383	0.1567	-13.7474	66.949	41.9859
53	8.5727	1.7979	5.9627	5.9116	-0.8659	5.009	-0.0653	0.4295	-0.3845	-0.8028	0.1133	-0.8466	-0.5047	0.8296	0.0878	0.3105	-0.0081	0.1126	0.3019	0.0311	0.1956	-4.723	65.1945	32.8005
54	4.8525	-2.5969	0.6185	1.6978	-1.5401	4.9106	-0.1784	0.85	0.0344	-1.4727	0.0021	0.1194	0.4622	0.4344	0.2377	0.6117	-0.0643	0.009	0.3335	0.059	0.1866	-12.0751	68.992	22.1318
55	1.2067	-0.6931	1.6543	1.201	-0.224	3.9699	-0.0006	0.2087	0.0706	-0.4286	-0.0232	-0.0156	-0.1788	0.1598	0.0302	0.2877	-0.0324	-0.0059	0.1977	0.0579	0.1438	-10.6691	72.7234	35.6592
56	0.4498	1.8555	0.9149	8.6021	5.9275	6.1322	0.0636	0.0514	-0.3926	0.8412	0.3231	-0.3929	0.6341	0.3923	-0.3626	0.2063	0.0551	-0.0577	0.2206	0.0096	0.2111	-8.7061	63.4651	52.1848
57	2.1683	-1.4381	-0.0732	2.3784	-0.6959	1.9115	-0.0939	-0.1102	0.1339	0.5068	0.2692	-0.5487	0.3146	0.4258	-0.0694	0.2264	0.0895	-0.1021	0.2275	-0.0931	0.3058	0.1158	35.849	46.5692
58	3.2077	0.3212	0.4638	0.2186	-0.6568	2.6724	-0.1714	0.0292	0.192	0.2112	0.2906	-0.4485	-0.0285	0.6992	-0.154	0.2042	-0.0126	-0.0601	0.3027	-0.155	0.4697	5.1895	42.5522	44.3544
59	4.7063	-0.7224	2.9027	0.2208	-0.8752	3.6612	-0.1963	-0.2716	0.2138	0.2259	0.3389	-0.4104	0.1913	0.301	-0.2253	0.1478	0.0645	-0.0359	0.1962	-0.0583	0.3173	1.915	32.5774	39.8649
60	6.4289	0.8952	1.4846	2.9473	-0.5185	4.4828	-0.1701	-0.0368	-0.3729	0.577	0.1286	0.3976	0.6132	-0.1711	-0.002	0.3478	-0.0406	0.0972	0.1337	-0.0236	0.2132	-14.2001	26.5282	45.6742
61	6.4369	-0.9691	-2.9893	5.777	1.3472	4.2653	-0.1183	-0.882	-0.3962	0.9095	0.0752	0.1221	0.6638	0.0391	0.0416	0.6232	0.0686	0.0006	0.3536	0.0569	0.2294	-13.7299	27.1198	58.7417
62	4.8121	-0.0442	-0.361	3.427	-1.2327	5.8423	0.0077	-0.1348	0.0162	0.4307	0.1637	0.2493	0.4414	-0.1554	-0.1519	0.2215	0.0004	0.0395	0.1274	0.0008	0.1936	-15.7105	33.3668	49.2601
63	6.3871	-0.9062	1.4082	1.7055	-1.3003	2.408	-0.1426	0.2646	0.1163	0.3905	0.3279	-0.6403	0.2611	0.7105	-0.0151	0.1956	0.0934	-0.0998	0.2869	-0.1129	0.3287	3.9664	32.4236	44.1001
64	6.4326	-3.0956	-0.11	4.3163	-1.1694	0.533	-0.0249	-0.4195	0.2432	1.0329	0.3408	-0.3558	0.3198	0.6464	0.1542	0.4297	0.1744	-0.2347	0.4135	-0.137	0.3386	5.9144	35.091	54.4769
65	2.1687	2.5702	-0.5066	8.6274	-0.9594	7.7052	-0.1905	-0.8268	0.8323	0.9506	0.4735	0.331	-0.117	-0.0046	-0.3325	0.4604	0.1373	-0.1515	0.4638	-0.1501	0.4554	-1.6997	44.7742	59.4099
66	4.5335	-1.2339	-1.5342	3.1479	1.0211	5.6086	-0.1501	-0.1483	-0.047	0.687	0.2168	-0.3795	0.1424	0.0853	-0.0596	0.2499	0.0665	-0.0362	0.1798	-0.0378	0.2512	-6.3849	43.5155	53.5976
67	3.5698	-1.353	1.1171	1.5179	-0.3346	1.139	-0.3061	-0.428	-0.0205	0.9686	0.3237	-0.21	0.5847	0.2816	-0.0446	0.5232	0.1429	-0.0369	0.254	-0.0225	0.2149	-0.7494	25.5044	50.6228
68	5.1632	0.1887	-0.461	7.3578	2.6393	4.7216	0.0693	0.1126	-0.0483	0.4515	0.3244	-0.8273	0.2531	0.5866	-0.3362	0.2306	0.0614	-0.0839	0.2311	-0.0767	0.2658	5.7392	24.9437	37.2407
69	2.3888	0.5272	0.1077	2.6732	-0.2843	6.3186	-0.1589	-0.0339	0.7174	-0.121	0.147	0.3427	-0.558	-0.5888	0.0174	0.1662	0.0271	0.003	0.202	0.0268	0.437	-5.5763	42.9121	25.071
70	3.6091	-0.4395	-1.5652	1.0004	-1.0641	2.4196	0.1035	-0.2917	0.6626	0.3034	0.1992	-0.5928	-0.355	0.3811	-0.2357	0.1439	-0.0571	0.0234	0.2308	-0.0951	0.4804	5.2949	44.9462	34.4164
71	5.6356	-0.4439	1.0687	2.7924	-1.1064	3.0656	-0.0294	-0.0245	0.421	0.1827	0.109	0.0684	-0.0563	0.1663	-0.0837	0.0886	-0.0085	0.0222	0.2093	-0.0241	0.2991	-3.4549	38.9776	32.4451
72	3.3436	0.8681	-0.4788	3.4165	-0.3565	6.9962	0.0037	0.6367	0.2609	-0.6369	0.1213	-0.4745	0.0872	0.2697	-0.1294	0.2003	0.0123	0.1202	0.3988	0.033	0.3345	8.2117	31.881	15.7497
73	2.8937	0.1589	-0.3524	0.9793	0.5536	2.2084	-0.0798	0.1198	0.4055	-0.2399	0.1093	-0.2504	-0.4533	0.2644	-0.0113	-0.2684	-0.0594	0.1181	0.2362	0.0112	0.4482	5.7812	36.4774	24.8594
74	2.6778	0.9466	-0.5479	1.0236	0.613	1.386	0.0228	0.4626	0.6928	-0.6766	0.5411	0.1748	-0.5489	0.0367	0.1536	0.3602	-0.1166	0.1949	0.0848	0.2243	0.7534	-0.8021	49.6401	23.1808
75	2.9444	1.6505	2.9917	6.7126	2.9489	3.315	0.3819	0.2874	0.9122	-0.2705	0.3676	-1.2803	-1.0183	1.1756	-0.4635	0.4806	-0.1613	0.1319	0.3805	-0.0084	0.7696	11.8103	53.2041	23.4281
76	1.9269	1.5311	0.2623	1.6816	-0.0862	0.511	0.1134	0.1847	0.51	-0.4577	-0.0409	-0.4192	-0.1896	0.2603	0.0054	0.129	-0.0749	0.124	0.2827	0.0276	0.5045	4.3544	41.7149	22.3202
77	1.6753	3.3537	1.799	8.6549	6.381	8.3868	-0.0003	-0.0626	0.2266	0.1597	-0.3121	0.5339	0.0176	-0.5748	0.2765	0.1074	0.0159	0.0087	0.1886	0.0164	0.2526	-11.12	34.0861	30.6747
78	2.5665	0.2594	-0.5136	2.8645	-1.1486	2.2187	-0.2285	0.2881	-0.2	-0.1638	-0.0347	0.3283	0.2121	0.0229	0.1544	-0.0475	-0.1816	0.2925	0.2247	0.0083	0.1158	-17.5243	13.4946	22.6177
79	5.6953	0.6728	-0.4569	1.9789	-1.0573	2.3546	-0.1556	0.4114	-0.4534	0.051	0.0524	0.225	0.2074	0.2173	0.1923	0.1143	-0.0309	0.0482	0.2376	-0.0885	0.292	-14.6495	5.0375	18.7585
80	4.1455	0.6051	0.1885	3.1372	-0.9385	3.7261	-0.2067	0.2893	-0.1531	0.0042	0.2341	0.1183	0.1271	-0.0114	0.0628	0.1108	-0.0455	0.0519	0.1926	0.0053	0.1707	-9.7738	14.1057	21.6832
81	2.3453	-1.4221	1.8714	3.3885	-0.7495	4.7191	-0.1318	-0.0072	0.1956	0.1435	-0.0444	0.205	0.0199	-0.1182	0.1302	0.1192	-0.0134	0.0676	0.2405	-0.0183	0.2801	-21.0601	26.3572	31.0093
82	4.6541	-0.5259	-0.937	1.5122	-1.3944	2.5237	0.4559	0.5778	-0.1281	0.037	-0.2902	1.0729	0.2248	-0.7493	-0.0669	0.106	-0.007	-0.0074	0.4077	-0.0027	0.5863	-31.4487	27.5661	23.3943
83	2.9604	-1.9676	1.7453	3.19	-0.776	1.1031	-0.2272	-0.2794	-0.0413	0.3474	-0.0337	0.5846	0.0836	-0.4006	-0.412	-0.1471	-0.1234	0.2966	0.2801	-0.0574	0.392	-28.3794	21.8708	30.9516
84	4.9338	-0.5031	-4.0968	4.2082	1.0284	6.1581	-0.087	0.1975	-0.1044	-0.0683	0.0089	0.0764	0.1183	0.0035	0.1044	0.0709	-0.0161	0.0215	0.1689	0.0073	0.1547	-13.8031	15.483	21.9287
85	7.3605	5.8472	-0.6751	7.9149	-2.0685	3.4598	-0.1973	1.0611	0.1644	-0.4676	0.1236	0.7828	-0.0052	-0.2487	0.0315	0.1339	-0.0671	-0.0297	0.418	-0.0625	0.2865	-20.2326	13.7239	11.7509
86	1.7217	0.4335	0.0363	1.3496	0.47	0.3512	-0.1754	0.3872	-0.0993	-0.1403	-0.1932	0.4852	-0.0946	-0.2538	0.0635	-0.0713	-0.0868	0.1001	0.327	-0.0632	0.3544	-24.5345	14.8365	19.3239
87	2.8352	2.8195	2.0366	7.6455	2.1175	1.4225	-0.113	0.0408	0.0567	-0.2906	0.4561	-0.3688	0.0491	0.2241	-0.3596	0.1578	-0.0484	0.0286	0.2176	0.0034	0.2024	-3.7658	20.8962	20.5704
88	1.9327	0.3283	1.3536	0.066	0.2488	0.9433	-0.0898	-0.2717	-0.2251	0.9882	0.2708	0.0779	0.2046	-0.1613	-0.1163	0.5258	0.0821	0.108	0.2027	0.0498	0.1631	-5.5143	5.1046	39.6325
89	4.7207	0.1989	-1.6334	1.5875	-0.6625	4.2392	-0.0813	0.0565	-0.2621	0.2566	-0.0033	0.2452	0.3174	-0.1826	0.0844	0.157	0.0002	0.0579	0.1138	-0.0198	0.1801	-6.8475	2.135	25.1622
90	3.1431	-0.7837	-2.4228	4.7525	-1.758	8.2747	-0.0425	-0.1011	0.0109	0.6158	0.133	0.3666	-0.0274	-0.3264	-0.0769	0.2463	0.0035	0.0347	0.1519	-0.0362	0.1299	-8.5629	10.1169	32.6121
91	6.0567	0.5438	-0.4664	7.1448	-4.7275	7.9788	-0.262	-0.3386	0.6883	0.604	0.1932	-0.6568	-0.3881	0.2038	0.0026	0.2085	0.0397	-0.0762	0.1672	-0.0827	0.3306	9.2674	15.3193	30.2737
92	1.3513	0.4852	-1.1195	0.6845	0.9775	9.0517	-0.5905	-0.8676	-0.3387	0.7309	0.4181	-0.7288	0.488	0.8406	0.0909	0.3531	0.1064	-0.1314	0.3993	-0.0298	0.4182	16.4149	5.1018	34.2292
93	6.7889	-0.5429	2.8793	4.8756	-0.3685	6.2864	-0.2016	0.0805	0.2677	0.321	0.1592	-0.7723	0.1537	0.4334	0.0336	0.1257	0.0186	-0.0085	0.1521	-0.029	0.1955	10.7753	8.9454	25.0233
94	3.7429	-1.3491	1.6263	1.6733	0.5564	2.5684	0.0698	-0.173	0.2138	0.7929	0.2077	0.5453	-0.0382	-0.3135	-0.2461	0.2965	0.0206	0.0835	0.1503	-0.0238	0.1788	-6.9307	7.2224	35.0516
95	5.0092	0.8158	-3.3004	4.8203	1.4065	3.1806	-0.2648	-0.2836	-0.2631	0.7205	0.4115	-0.171	0.7355	0.0454	-0.1071	0.518	0.091	0.0521	0.1889	0.0373	0.2404	-3.8625	-2.7861	37.9441
96	2.8934	4.4486	1.591	7.1555	4.026	9.5022	-0.1686	0.2644	-0.7528	0.1047	0.0786	-0.4852	1.2643	0.7456	0.1105	0.5367	0.1097	0.0778	0.2765	0.0244	0.3133	2.3443	-9.7696	28.3215
97	0.5344	-0.465	-0.1274	1.3766	0.9502	1.9792	-0.1632	-0.1289	0.0133	0.6916	0.1539	-0.0589	0.429	0.0947	0.0107	0.309	0.0527	-0.0175	0.1863	-0.0066	0.1507	2.5405	3.1659	33.1338
98	2.8495	2.7251	3.3229	9.0918	5.188	4.492	0.0956	-0.3494	0.1746	0.8261	-0.2962	0.496	0.3705	-0.3931	0.1473	0.3916	0.0341	0.0482	0.2174	0.0042	0.1705	-9.9156	16.2452	39.0656
99	5.6438	1.3115	-2.8413	4.974	-0.578	3.6601	-0.063	-0.2723	-0.2002	0.1384	-0.1021	0.3827	0.1539	0.1162	0.1726	0.1382	0.0008	-0.0049	0.23	-0.0127	0.1917	-10.9299	-8.4608	4.0208
100	2.4538	1.5612	-0.1523	4.6777	1.0256	2.9969	0.1617	0.6794	0.216	-0.8652	-0.1316	0.2145	-0.3696	-0.0549	-0.0346	0.3197	0.0695	-0.0306	0.2677	0.0474	0.1448	-3.4441	0.4856	-11.3074
101	7.6134	-1.8072	-5.0499	5.8709	1.0868	3.4753	0.0474	-0.169	0.3427	-0.264	-0.0452	0.1761	-0.4245	-0.3872	-0.0081	0.1922	0.04	-0.051	0.2362	-0.0157	0.166	-6.3362	3.7914	1.2935
102	4.1049	-1.7278	-3.3476	3.5231	1.1352	7.7086	-0.0019	0.1433	0.058	-0.099	-0.0554	0.2345	-0.0265	-0.3403	0.077	0.0766	-0.0224	-0.0104	0.2073	0.0188	0.1224	-3.2323	-6.4072	2.5637
103	5.2664	1.1733	-0.9478	1.9723	2.1264	3.4739	0.3241	0.3573	-0.1636	-0.2088	-0.2769	0.2699	0.2191	-0.097	-0.0391	0.3636	0.0542	-0.1057	0.2895	-0.0339	0.2029	-6.7783	-16.6921	-12.4496
104	7.3554	-3.2172	4.0864	1.4069	-1.7925	2.2873	-0.2486	0.6431	0.1529	-0.8067	0.015	1.4413	0.1821	-1.0949	-0.0544	0.4454	-0.0357	-0.2355	0.6316	-0.055	0.4894	-18.8173	-14.55	-15.4104
105	1.8172	-0.0651	1.1749	1.9844	0.2831	7.7643	0.0637	0.2299	-0.1157	-0.4686	-0.1565	0.2752	0.0092	-0.2862	0.0868	0.2031	0.0532	-0.0634	0.2119	-0.0143	0.1599	-7.379	-8.9306	-10.1463
106	4.3095	-0.012	0.3958	5.4354	-3.9987	5.288	0.0495	-0.0584	-0.0872	0.0554	-0.0372	0.8165	-0.3716	-0.8172	-0.0313	0.1448	0.0703	-0.0204	0.3562	-0.0582	0.2892	-17.0404	-2.0008	3.724
107	3.798	-1.1433	2.5884	4.4477	-4.6439	5.396	0.2208	1.1183	0.1962	-0.6753	-0.0362	0.73	-0.6149	-0.9053	0.1297	0.4184	0.2213	-0.13	0.6561	-0.0399	0.3667	-19.3528	5.2208	-9.0456
108	2.0613	-0.876	0.5116	0.9908	-1.7794	4.0788	0.1028	0.3261	-0.0198	-0.4333	-0.1789	0.2147	-0.3167	-0.6219	0.1241	0.3715	0.0945	-0.117	0.3394	-0.0224	0.2261	-12.948	2.4023	-11.8313
109	0.7535	-1.0504	0.7593	2.6446	-0.7249	2.0893	0.1005	-0.157	-0.1283	-0.2211	-0.0887	0.7345	0.0131	-0.5044	-0.0249	0.1186	-0.0178	-0.0503	0.2904	-0.0339	0.2981	-14.0005	-13.4011	-1.1083
110	2.8513	-0.5012	1.2489	8.2706	3.8174	3.5113	0.0377	0.0206	-0.017	0.7953	-0.0114	-0.0075	0.0317	0.0837	-0.0192	0.2008	-0.0534	0.0182	0.2008	0.0189	0.1415	-2.3995	-13.6485	7.8061
111	3.2357	-0.6061	-0.9291	0.9638	0.0196	4.7125	0.152	0.2943	0.272	-0.4879	0.1297	-0.4639	-0.4705	0.4816	0.0121	0.2629	-0.0709	0.147	0.2845	0.0379	0.2709	14.5191	-0.4153	-4.4879
112	3.7388	-0.6462	0.5334	3.1475	0.4566	4.1282	0.0485	0.0145	0.2324	-0.2326	-0.0936	-0.0401	-0.3187	-0.0867	0.0416	0.1114	-0.0069	0.0021	0.1156	0.0104	0.1369	3.2511	4.7312	4.2034
113	3.7066	2.347	-1.8805	4.2644	-0.6091	5.2372	0.0003	0.2548	0.1657	-0.4326	0.0879	-0.093	-0.1546	-0.186	-0.0596	0.1246	0.0034	0.0476	0.1643	0.0378	0.1306	6.2317	-3.6965	-2.9596
114	1.9205	0.7166	0.3131	1.9568	0.0742	2.9729	0.0389	-0.1119	0.0967	0.0091	0.1105	-0.6183	0.1658	0.2596	-0.1114	0.0865	0.0113	-0.0177	0.201	-0.0286	0.2831	16.7865	-7.1908	14.8274
115	2.9251	-0.1416	-0.3447	1.9501	0.2762	3.1546	-0.0539	0.2533	0.3452	-0.4626	0.1128	-0.4554	-0.3049	0.2855	-0.0597	0.1973	-0.0613	0.086	0.2268	0.0361	0.255	13.4955	3.812	-2.1481
116	7.6434	2.2326	0.2711	2.1248	1.9635	2.9519	0.4064	-0.7218	0.7082	0.6763	-0.0713	-0.1672	-1.3756	0.5239	-0.3431	0.4801	-0.1099	0.0216	0.332	0.0089	0.4258	13.4733	14.5766	9.5995
117	0.8211	-0.3156	-0.139	1.5309	0.4346	0.5634	0.0458	0.046	0.2074	-0.147	0.1719	-0.6114	-0.1115	0.2416	-0.204	0.123	-0.0475	0.0562	0.2412	-0.0115	0.2867	15.2933	0.73	5.7553
118	2.6213	0.1577	0.2025	5.1781	-0.8347	1.2163	0.2758	0.5761	-0.0317	-0.9316	-0.1834	-0.006	-0.4094	-0.1751	0.0243	0.312	0.0468	0.0703	0.3226	0.0338	0.1622	8.8175	-10.1415	-8.7417
119	4.5588	-0.6625	1.2416	5.076	0.1855	4.2049	-0.0034	0.3211	-0.1669	-0.2433	-0.0737	0.6997	0.4182	-0.4589	0.0721	0.2728	-0.0996	-0.0253	0.3043	-0.0226	0.2149	-5.6174	-35.4372	1.5087
120	6.9143	-1.0841	-3.9775	4.6976	2.7427	7.5776	0.1925	-0.4663	-0.2383	0.592	-0.0705	-0.4438	0.5545	0.3205	-0.0393	0.2521	-0.0103	-0.0789	0.1861	0.054	0.1702	12.8084	-36.2879	10.2456
121	2.7288	3.1513	3.5331	5.0182	2.4289	6.6409	0.0271	0.1628	-0.2533	-0.0961	0.0436	-0.0788	0.5714	-0.1144	-0.1219	0.3715	0.0142	-0.0334	0.1997	0.0021	0.1995	5.7779	-42.1614	0.3377
122	7.1713	1.747	1.4119	5.7306	-2.0915	3.3791	-0.2015	-0.0888	0.0078	-0.3628	0.086	0.1812	0.2009	-0.1566	0.1013	0.1639	0.0083	0.0347	0.1865	0.0227	0.095	2.8641	-32.0969	-0.8372
123	6.2997	1.935	-3.3526	3.7837	-2.9734	5.8165	0.1839	0.1563	0.1595	0.4243	-0.1358	0.0564	-0.6719	-0.3188	-0.0307	0.2825	-0.0148	-0.0319	0.2292	0.0062	0.1286	2.731	-22.4553	15.3503
124	0.3388	0.203	1.099	4.0951	-3.4788	7.9691	0.0114	-1.4159	-0.726	0.9594	0.0107	0.56	1.2319	-0.2447	0.0042	0.5524	-0.0951	0.08	0.583	0.1062	0.2779	-3.5332	-30.2822	23.5211
125	3.4412	0.266	1.6042	2.6542	0.7529	4.237	0.0853	-0.1503	-0.1614	0.3256	0.0403	-0.005	0.1732	0.0101	-0.0943	0.2379	-0.0369	0.005	0.138	0.0533	0.1277	3.7003	-31.0835	11.0488
126	8.6122	-3.5654	1.2277	5.3678	-3.9346	3.2024	0.0954	-0.1076	-0.6719	0.3728	0.193	0.7355	0.9575	-0.7008	-0.2971	0.4319	-0.162	0.0068	0.2656	0.0439	0.2482	-5.0806	-42.6699	5.8053
127	6.4584	-0.4664	-0.8822	2.9681	0.0095	2.8079	0.2556	-1.073	-0.956	0.7281	-0.3707	-0.1751	0.7444	0.4426	0.1344	0.9502	-0.1541	-0.1319	0.3577	0.1276	0.3506	2.5996	-48.7962	15.2163
128	0.9897	-0.8344	0.8144	2.7284	-0.5234	2.1093	0.1347	-0.2067	-0.1629	0.4452	-0.0857	0.1984	0.4433	-0.226	-0.0747	0.3207	-0.1011	0.0221	0.2313	0.033	0.1712	-0.7153	-35.5993	11.344
129	4.3661	-3.7502	-2.3423	3.2892	2.4052	3.7189	0.3597	0.4109	-0.1762	-0.8085	-0.5634	0.5259	0.1145	-0.2108	0.2877	0.2791	0.0116	-0.0531	0.2701	-0.0041	0.2001	-2.5417	-26.0748	-4.8507
130	1.5662	-1.2724	-1.3561	3.1721	-0.1693	1.9338	0.1683	-0.4798	0.2514	-0.1255	-0.0272	-1.0391	0.1685	0.6387	0.0271	0.2059	0.0314	0.0005	0.3354	-0.0386	0.4156	22.3208	-28.0903	-3.9786
131	3.8227	1.2173	1.7324	2.8142	1.3932	5.6389	0.1067	-0.0439	-0.2304	-0.093	0.0474	-0.3905	0.5406	0.1216	-0.2226	0.3026	0.0521	0.0064	0.1557	-0.0084	0.1953	12.293	-38.6093	-6.7078
132	9.1634	-0.7276	2.5173	3.1387	1.27	4.77	0.0649	-0.1429	-0.0729	-0.0431	0.1272	-0.3939	0.2247	0.336	-0.1094	0.1161	-0.0041	0.0012	0.1678	-0.0069	0.1707	13.7365	-29.141	-1.1116
133	3.9383	-0.5589	-0.1171	0.1192	0.0998	5.5497	-0.0584	0.8349	-0.1752	-0.9513	-0.0074	-0.5855	-0.2847	0.339	-0.0231	0.5605	-0.0226	0.2072	0.3351	-0.0182	0.2993	12.9617	-21.6105	-20.7436
134	2.7647	0.3065	0.5161	2.6308	0.3577	4.0067	0.0646	0.1192	-0.103	-0.5829	0.0518	-0.3751	0.0082	-0.012	-0.0545	0.2795	0.0232	0.0709	0.1502	-0.019	0.1773	12.2655	-28.0837	-12.8918
135	6.9471	3.0924	2.556	3.7715	-0.5242	2.0996	0.3626	-0.0634	-0.2903	-0.7715	0.0084	-1.0457	-0.0151	0.9546	-0.1355	0.2962	0.0804	0.1563	0.4642	-0.1033	0.5473	25.5521	-34.1555	-8.464
136	4.1805	-0.7576	1.7421	9.3473	-0.7623	1.8317	0.3966	1.1336	-0.9566	-2.0253	-0.1874	-0.234	0.7958	0.687	-0.0894	0.6655	0.1921	0.1252	0.5484	-0.0651	0.5502	21.3937	-42.4376	-18.433
137	0.5286	0.0412	0.3665	3.2179	0.5083	1.3101	0.0204	0.2481	-0.1579	-0.4272	0.2105	-0.5892	0.0878	0.2941	-0.1933	0.2805	0.011	0.1408	0.2859	-0.0471	0.2838	18.1987	-29.7146	-13.3107
138	3.0627	0.6474	-1.3059	2.0659	1.0942	4.0396	0.1192	-0.2305	-0.2417	0.4426	0.2335	-0.4772	0.1843	0.1528	-0.1963	0.2123	-0.024	-0.0278	0.2693	0.0152	0.2976	15.4002	-21.5278	3.502
139	6.4623	-1.8623	1.5185	4.4688	-0.4313	5.3682	-0.0633	-0.8699	0.3399	0.8012	-0.1581	-0.3688	0.1739	0.3882	0.0986	0.4933	-0.0942	-0.0579	0.4083	0.0304	0.2633	-1.2954	-60.2205	-11.0175
140	5.0175	-2.0373	1.8102	6.8443	-0.4683	3.699	0.1212	-0.4684	0.2143	0.742	-0.3168	0.977	0.2531	-0.6086	0.2315	0.3641	-0.1218	0.1043	0.4034	-0.1091	0.3755	-17.7647	-57.6587	-17.489
141	2.1294	-0.2105	2.7269	0.4123	0.5716	5.3183	0.1731	-0.5473	0.4764	0.6599	-0.5992	0.5599	-0.1224	0.0288	0.3587	0.5485	-0.181	0.1256	0.3659	-0.1246	0.2807	-8.546	-50.1121	-11.201
142	2.9879	-1.7821	-0.3548	1.9957	-1.2114	2.2642	0.2092	-0.6644	0.2418	0.2734	-0.1945	-0.0873	0.217	0.0806	0.0342	0.3314	-0.0959	0.0111	0.3451	-0.0563	0.175	-2.3432	-55.9599	-17.3701
143	3.268	0.2282	0.0427	4.8851	-0.6643	4.7416	-0.1123	-0.0327	-0.5213	0.8227	-0.3424	0.0951	0.4976	-0.1087	0.3064	0.5013	-0.1617	0.044	0.2942	0.0072	0.3014	-9.4383	-72.7995	-20.7252
144	4.8841	0.9872	-0.1802	2.5341	-2.3132	2.2275	0.0454	-1.233	-0.9111	0.9865	0.0096	0.9094	0.4689	-0.3325	0.0509	0.9941	-0.2465	0.1764	0.6265	0.1295	0.5387	-12.8082	-77.719	-9.2633
145	2.0766	-0.3179	-0.9775	4.2151	-2.4743	2.1096	0.1281	-0.4022	-0.3499	0.4683	-0.2026	0.7395	0.9159	-0.3923	-0.1101	0.5464	-0.2523	0.066	0.4003	-0.0151	0.4302	-16.8102	-70.8567	-17.6094
146	4.331	-1.4568	1.9563	2.007	0.5568	4.2425	0.1621	-0.7295	0.1861	0.7034	-0.1416	-0.1337	-0.0083	-0.0673	0.1202	0.4479	-0.169	-0.0126	0.367	-0.0096	0.1731	-1.741	-57.4814	-12.0517
147	5.2842	-3.6273	2.8462	2.7555	-0.6759	7.4676	-0.0905	-1.1159	-0.2332	1.2037	0.0727	0.403	0.389	0.1569	0.0624	0.7625	-0.2295	0.0856	0.6659	0.0076	0.2703	-5.9877	-58.4342	-3.4218
148	0.014	0.1399	0.006	1.2707	0.0854	0.0065	0.2344	-0.0795	0.0286	0.7084	-0.0696	0.5297	0.0269	-1.1979	0.5179	1.1274	-0.3136	0.5143	1.0451	-0.3606	0.4307	-18.0319	-58.8222	-1.0486
149	3.1418	-0.7299	-1.3098	3.2913	0.8382	3.0946	0.2786	-0.7591	-0.2155	0.874	-0.2989	0.5261	0.2633	-0.268	0.0331	0.6101	-0.2327	0.0796	0.4741	0.0162	0.3062	-9.26	-64.3327	-9.7876
150	4.57	-4.7771	-4.023	8.9326	2.4193	4.319	0.12	-0.2239	0.1559	0.3343	0.0875	-0.8713	-0.0127	0.0589	-0.1677	0.3619	-0.0496	-0.1065	0.3562	-0.0093	0.3003	6.0038	-58.5498	-19.6596
151	6.6153	0.2725	1.8801	8.695	2.2205	6.5593	0.5265	0.3192	-0.4091	-0.5545	-0.249	0.9207	-0.0099	-0.4442	-0.3185	0.3921	0.0306	-0.0682	0.2959	-0.0433	0.3079	-12.665	-47.6681	-33.2277
152	0.6513	0.6825	-0.4123	3.5502	1.0856	2.353	0.151	-0.0623	0.1725	0.2223	-0.351	0.5346	-0.0801	-0.2623	0.2066	0.3841	-0.0067	0.0176	0.289	-0.0823	0.2912	-7.2171	-44.1909	-19.5352
153	2.6646	0.134	0.8557	5.744	1.0933	2.6601	0.3292	-0.1364	-0.117	-0.1024	-0.3203	0.3802	-0.0217	-0.2143	0.0141	0.3001	-0.0127	-0.0095	0.2571	-0.0713	0.1978	-8.4544	-52.8946	-26.2384
154	4.7948	1.8266	-0.1119	4.3635	-2.4268	3.3322	-0.0648	0.5123	0.2307	-0.9208	0.1363	-0.418	-0.8148	0.1478	-0.0125	0.6527	-0.0627	0.191	0.3142	-0.0455	0.3298	7.5097	-43.1668	-35.9837
155	6.528	1.0439	0.7895	5.2352	1.0074	3.5386	0.1921	0.0518	0.0583	-0.3603	-0.0781	-0.1818	-0.3242	-0.0054	-0.1308	0.2979	0.0094	0.0322	0.1422	-0.0346	0.1408	0.5178	-45.5473	-28.849
156	6.1967	4.4981	2.361	3.5899	1.4018	1.7116	-0.4452	-0.3237	0.8183	-1.0461	0.0483	0.565	-1.1528	-0.529	0.2274	0.4866	0.1148	-0.1323	0.2937	-0.0874	0.4612	-13.4102	-40.077	-31.4098
157	1.3102	-1.4384	-0.8807	4.3091	4.0016	4.0098	-0.4595	-0.8011	0.9869	0.0245	0.0137	0.1844	-1.5327	-0.0623	0.4286	0.6387	0.063	-0.1204	0.4356	-0.0989	0.5517	-7.5675	-30.1938	-25.0272
158	1.4029	0.2939	0.5543	4.9715	2.4499	2.8723	-0.0378	0.004	0.1487	-0.3493	-0.1912	0.3001	-0.4352	-0.1089	0.2492	0.4148	0.0167	-0.0204	0.2217	-0.0297	0.2114	-3.7877	-41.7693	-31.1545
159	4.7698	-1.7718	-1.1203	7.1186	5.0154	3.5473	0.0512	-0.609	-0.0746	0.1593	-0.6515	0.7124	-0.1549	-0.9603	0.5908	0.3831	-0.019	-0.024	0.3782	-0.0837	0.2881	-9.8602	-59.746	-31.896

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 2 through 40 )	A	2 - 40
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 41 through 59 )	A	41 - 59
3	X-RAY DIFFRACTION	3	chain 'A' and (resid 60 through 80 )	A	60 - 80
4	X-RAY DIFFRACTION	4	chain 'A' and (resid 81 through 90 )	A	81 - 90
5	X-RAY DIFFRACTION	5	chain 'A' and (resid 91 through 102 )	A	91 - 102
6	X-RAY DIFFRACTION	6	chain 'A' and (resid 103 through 132 )	A	103 - 132
7	X-RAY DIFFRACTION	7	chain 'A' and (resid 133 through 141 )	A	133 - 141
8	X-RAY DIFFRACTION	8	chain 'B' and (resid 2 through 40 )	B	2 - 40
9	X-RAY DIFFRACTION	9	chain 'B' and (resid 41 through 50 )	B	41 - 50
10	X-RAY DIFFRACTION	10	chain 'B' and (resid 51 through 71 )	B	51 - 71
11	X-RAY DIFFRACTION	11	chain 'B' and (resid 72 through 80 )	B	72 - 80
12	X-RAY DIFFRACTION	12	chain 'B' and (resid 81 through 90 )	B	81 - 90
13	X-RAY DIFFRACTION	13	chain 'B' and (resid 91 through 102 )	B	91 - 102
14	X-RAY DIFFRACTION	14	chain 'B' and (resid 103 through 132 )	B	103 - 132
15	X-RAY DIFFRACTION	15	chain 'B' and (resid 133 through 141 )	B	133 - 141
16	X-RAY DIFFRACTION	16	chain 'C' and (resid 3 through 10 )	C	3 - 10
17	X-RAY DIFFRACTION	17	chain 'C' and (resid 11 through 19 )	C	11 - 19
18	X-RAY DIFFRACTION	18	chain 'C' and (resid 20 through 30 )	C	20 - 30
19	X-RAY DIFFRACTION	19	chain 'C' and (resid 31 through 40 )	C	31 - 40
20	X-RAY DIFFRACTION	20	chain 'C' and (resid 41 through 50 )	C	41 - 50
21	X-RAY DIFFRACTION	21	chain 'C' and (resid 51 through 59 )	C	51 - 59
22	X-RAY DIFFRACTION	22	chain 'C' and (resid 60 through 71 )	C	60 - 71
23	X-RAY DIFFRACTION	23	chain 'C' and (resid 72 through 81 )	C	72 - 81
24	X-RAY DIFFRACTION	24	chain 'C' and (resid 82 through 90 )	C	82 - 90
25	X-RAY DIFFRACTION	25	chain 'C' and (resid 91 through 102 )	C	91 - 102
26	X-RAY DIFFRACTION	26	chain 'C' and (resid 103 through 132 )	C	103 - 132
27	X-RAY DIFFRACTION	27	chain 'C' and (resid 133 through 141 )	C	133 - 141
28	X-RAY DIFFRACTION	28	chain 'D' and (resid 2 through 40 )	D	2 - 40
29	X-RAY DIFFRACTION	29	chain 'D' and (resid 41 through 50 )	D	41 - 50
30	X-RAY DIFFRACTION	30	chain 'D' and (resid 51 through 59 )	D	51 - 59
31	X-RAY DIFFRACTION	31	chain 'D' and (resid 60 through 80 )	D	60 - 80
32	X-RAY DIFFRACTION	32	chain 'D' and (resid 81 through 90 )	D	81 - 90
33	X-RAY DIFFRACTION	33	chain 'D' and (resid 91 through 102 )	D	91 - 102
34	X-RAY DIFFRACTION	34	chain 'D' and (resid 103 through 132 )	D	103 - 132
35	X-RAY DIFFRACTION	35	chain 'D' and (resid 133 through 141 )	D	133 - 141
36	X-RAY DIFFRACTION	36	chain 'E' and (resid 3 through 30 )	E	3 - 30
37	X-RAY DIFFRACTION	37	chain 'E' and (resid 31 through 40 )	E	31 - 40
38	X-RAY DIFFRACTION	38	chain 'E' and (resid 41 through 50 )	E	41 - 50
39	X-RAY DIFFRACTION	39	chain 'E' and (resid 51 through 59 )	E	51 - 59
40	X-RAY DIFFRACTION	40	chain 'E' and (resid 60 through 81 )	E	60 - 81
41	X-RAY DIFFRACTION	41	chain 'E' and (resid 82 through 90 )	E	82 - 90
42	X-RAY DIFFRACTION	42	chain 'E' and (resid 91 through 102 )	E	91 - 102
43	X-RAY DIFFRACTION	43	chain 'E' and (resid 103 through 132 )	E	103 - 132
44	X-RAY DIFFRACTION	44	chain 'E' and (resid 133 through 141 )	E	133 - 141
45	X-RAY DIFFRACTION	45	chain 'F' and (resid 1 through 10 )	F	1 - 10
46	X-RAY DIFFRACTION	46	chain 'F' and (resid 11 through 19 )	F	11 - 19
47	X-RAY DIFFRACTION	47	chain 'F' and (resid 20 through 30 )	F	20 - 30
48	X-RAY DIFFRACTION	48	chain 'F' and (resid 31 through 40 )	F	31 - 40
49	X-RAY DIFFRACTION	49	chain 'F' and (resid 41 through 50 )	F	41 - 50
50	X-RAY DIFFRACTION	50	chain 'F' and (resid 51 through 59 )	F	51 - 59
51	X-RAY DIFFRACTION	51	chain 'F' and (resid 60 through 68 )	F	60 - 68
52	X-RAY DIFFRACTION	52	chain 'F' and (resid 69 through 80 )	F	69 - 80
53	X-RAY DIFFRACTION	53	chain 'F' and (resid 81 through 90 )	F	81 - 90
54	X-RAY DIFFRACTION	54	chain 'F' and (resid 91 through 102 )	F	91 - 102
55	X-RAY DIFFRACTION	55	chain 'F' and (resid 103 through 132 )	F	103 - 132
56	X-RAY DIFFRACTION	56	chain 'F' and (resid 133 through 141 )	F	133 - 141
57	X-RAY DIFFRACTION	57	chain 'G' and (resid 1 through 19 )	G	1 - 19
58	X-RAY DIFFRACTION	58	chain 'G' and (resid 20 through 30 )	G	20 - 30
59	X-RAY DIFFRACTION	59	chain 'G' and (resid 31 through 40 )	G	31 - 40
60	X-RAY DIFFRACTION	60	chain 'G' and (resid 41 through 50 )	G	41 - 50
61	X-RAY DIFFRACTION	61	chain 'G' and (resid 51 through 59 )	G	51 - 59
62	X-RAY DIFFRACTION	62	chain 'G' and (resid 60 through 71 )	G	60 - 71
63	X-RAY DIFFRACTION	63	chain 'G' and (resid 72 through 80 )	G	72 - 80
64	X-RAY DIFFRACTION	64	chain 'G' and (resid 81 through 90 )	G	81 - 90
65	X-RAY DIFFRACTION	65	chain 'G' and (resid 91 through 102 )	G	91 - 102
66	X-RAY DIFFRACTION	66	chain 'G' and (resid 103 through 115 )	G	103 - 115
67	X-RAY DIFFRACTION	67	chain 'G' and (resid 116 through 132 )	G	116 - 132
68	X-RAY DIFFRACTION	68	chain 'G' and (resid 133 through 141 )	G	133 - 141
69	X-RAY DIFFRACTION	69	chain 'H' and (resid 1 through 10 )	H	1 - 10
70	X-RAY DIFFRACTION	70	chain 'H' and (resid 11 through 30 )	H	11 - 30
71	X-RAY DIFFRACTION	71	chain 'H' and (resid 31 through 40 )	H	31 - 40
72	X-RAY DIFFRACTION	72	chain 'H' and (resid 41 through 59 )	H	41 - 59
73	X-RAY DIFFRACTION	73	chain 'H' and (resid 60 through 80 )	H	60 - 80
74	X-RAY DIFFRACTION	74	chain 'H' and (resid 81 through 90 )	H	81 - 90
75	X-RAY DIFFRACTION	75	chain 'H' and (resid 91 through 102 )	H	91 - 102
76	X-RAY DIFFRACTION	76	chain 'H' and (resid 103 through 132 )	H	103 - 132
77	X-RAY DIFFRACTION	77	chain 'H' and (resid 133 through 141 )	H	133 - 141
78	X-RAY DIFFRACTION	78	chain 'I' and (resid 2 through 19 )	I	2 - 19
79	X-RAY DIFFRACTION	79	chain 'I' and (resid 20 through 30 )	I	20 - 30
80	X-RAY DIFFRACTION	80	chain 'I' and (resid 31 through 40 )	I	31 - 40
81	X-RAY DIFFRACTION	81	chain 'I' and (resid 41 through 50 )	I	41 - 50
82	X-RAY DIFFRACTION	82	chain 'I' and (resid 51 through 59 )	I	51 - 59
83	X-RAY DIFFRACTION	83	chain 'I' and (resid 60 through 68 )	I	60 - 68
84	X-RAY DIFFRACTION	84	chain 'I' and (resid 69 through 80 )	I	69 - 80
85	X-RAY DIFFRACTION	85	chain 'I' and (resid 81 through 90 )	I	81 - 90
86	X-RAY DIFFRACTION	86	chain 'I' and (resid 91 through 132 )	I	91 - 132
87	X-RAY DIFFRACTION	87	chain 'I' and (resid 133 through 141 )	I	133 - 141
88	X-RAY DIFFRACTION	88	chain 'J' and (resid 1 through 10 )	J	1 - 10
89	X-RAY DIFFRACTION	89	chain 'J' and (resid 11 through 30 )	J	11 - 30
90	X-RAY DIFFRACTION	90	chain 'J' and (resid 31 through 40 )	J	31 - 40
91	X-RAY DIFFRACTION	91	chain 'J' and (resid 41 through 50 )	J	41 - 50
92	X-RAY DIFFRACTION	92	chain 'J' and (resid 51 through 59 )	J	51 - 59
93	X-RAY DIFFRACTION	93	chain 'J' and (resid 60 through 71 )	J	60 - 71
94	X-RAY DIFFRACTION	94	chain 'J' and (resid 72 through 80 )	J	72 - 80
95	X-RAY DIFFRACTION	95	chain 'J' and (resid 81 through 90 )	J	81 - 90
96	X-RAY DIFFRACTION	96	chain 'J' and (resid 91 through 102 )	J	91 - 102
97	X-RAY DIFFRACTION	97	chain 'J' and (resid 103 through 132 )	J	103 - 132
98	X-RAY DIFFRACTION	98	chain 'J' and (resid 133 through 141 )	J	133 - 141
99	X-RAY DIFFRACTION	99	chain 'K' and (resid 2 through 10 )	K	2 - 10
100	X-RAY DIFFRACTION	100	chain 'K' and (resid 11 through 19 )	K	11 - 19
101	X-RAY DIFFRACTION	101	chain 'K' and (resid 20 through 30 )	K	20 - 30
102	X-RAY DIFFRACTION	102	chain 'K' and (resid 31 through 40 )	K	31 - 40
103	X-RAY DIFFRACTION	103	chain 'K' and (resid 41 through 50 )	K	41 - 50
104	X-RAY DIFFRACTION	104	chain 'K' and (resid 51 through 59 )	K	51 - 59
105	X-RAY DIFFRACTION	105	chain 'K' and (resid 60 through 78 )	K	60 - 78
106	X-RAY DIFFRACTION	106	chain 'K' and (resid 79 through 90 )	K	79 - 90
107	X-RAY DIFFRACTION	107	chain 'K' and (resid 91 through 102 )	K	91 - 102
108	X-RAY DIFFRACTION	108	chain 'K' and (resid 103 through 115 )	K	103 - 115
109	X-RAY DIFFRACTION	109	chain 'K' and (resid 116 through 132 )	K	116 - 132
110	X-RAY DIFFRACTION	110	chain 'K' and (resid 133 through 141 )	K	133 - 141
111	X-RAY DIFFRACTION	111	chain 'L' and (resid 1 through 10 )	L	1 - 10
112	X-RAY DIFFRACTION	112	chain 'L' and (resid 11 through 30 )	L	11 - 30
113	X-RAY DIFFRACTION	113	chain 'L' and (resid 31 through 40 )	L	31 - 40
114	X-RAY DIFFRACTION	114	chain 'L' and (resid 41 through 71 )	L	41 - 71
115	X-RAY DIFFRACTION	115	chain 'L' and (resid 72 through 90 )	L	72 - 90
116	X-RAY DIFFRACTION	116	chain 'L' and (resid 91 through 102 )	L	91 - 102
117	X-RAY DIFFRACTION	117	chain 'L' and (resid 103 through 132 )	L	103 - 132
118	X-RAY DIFFRACTION	118	chain 'L' and (resid 133 through 141 )	L	133 - 141
119	X-RAY DIFFRACTION	119	chain 'M' and (resid 1 through 10 )	M	1 - 10
120	X-RAY DIFFRACTION	120	chain 'M' and (resid 11 through 19 )	M	11 - 19
121	X-RAY DIFFRACTION	121	chain 'M' and (resid 20 through 30 )	M	20 - 30
122	X-RAY DIFFRACTION	122	chain 'M' and (resid 31 through 40 )	M	31 - 40
123	X-RAY DIFFRACTION	123	chain 'M' and (resid 41 through 50 )	M	41 - 50
124	X-RAY DIFFRACTION	124	chain 'M' and (resid 51 through 59 )	M	51 - 59
125	X-RAY DIFFRACTION	125	chain 'M' and (resid 60 through 80 )	M	60 - 80
126	X-RAY DIFFRACTION	126	chain 'M' and (resid 81 through 90 )	M	81 - 90
127	X-RAY DIFFRACTION	127	chain 'M' and (resid 91 through 102 )	M	91 - 102
128	X-RAY DIFFRACTION	128	chain 'M' and (resid 103 through 132 )	M	103 - 132
129	X-RAY DIFFRACTION	129	chain 'M' and (resid 133 through 141 )	M	133 - 141
130	X-RAY DIFFRACTION	130	chain 'N' and (resid 1 through 10 )	N	1 - 10
131	X-RAY DIFFRACTION	131	chain 'N' and (resid 11 through 30 )	N	11 - 30
132	X-RAY DIFFRACTION	132	chain 'N' and (resid 31 through 40 )	N	31 - 40
133	X-RAY DIFFRACTION	133	chain 'N' and (resid 41 through 59 )	N	41 - 59
134	X-RAY DIFFRACTION	134	chain 'N' and (resid 60 through 80 )	N	60 - 80
135	X-RAY DIFFRACTION	135	chain 'N' and (resid 81 through 90 )	N	81 - 90
136	X-RAY DIFFRACTION	136	chain 'N' and (resid 91 through 102 )	N	91 - 102
137	X-RAY DIFFRACTION	137	chain 'N' and (resid 103 through 132 )	N	103 - 132
138	X-RAY DIFFRACTION	138	chain 'N' and (resid 133 through 141 )	N	133 - 141
139	X-RAY DIFFRACTION	139	chain 'O' and (resid 3 through 10 )	O	3 - 10
140	X-RAY DIFFRACTION	140	chain 'O' and (resid 11 through 19 )	O	11 - 19
141	X-RAY DIFFRACTION	141	chain 'O' and (resid 20 through 30 )	O	20 - 30
142	X-RAY DIFFRACTION	142	chain 'O' and (resid 31 through 40 )	O	31 - 40
143	X-RAY DIFFRACTION	143	chain 'O' and (resid 41 through 50 )	O	41 - 50
144	X-RAY DIFFRACTION	144	chain 'O' and (resid 51 through 59 )	O	51 - 59
145	X-RAY DIFFRACTION	145	chain 'O' and (resid 60 through 71 )	O	60 - 71
146	X-RAY DIFFRACTION	146	chain 'O' and (resid 72 through 81 )	O	72 - 81
147	X-RAY DIFFRACTION	147	chain 'O' and (resid 82 through 90 )	O	82 - 90
148	X-RAY DIFFRACTION	148	chain 'O' and (resid 91 through 102 )	O	91 - 102
149	X-RAY DIFFRACTION	149	chain 'O' and (resid 103 through 132 )	O	103 - 132
150	X-RAY DIFFRACTION	150	chain 'O' and (resid 133 through 141 )	O	133 - 141
151	X-RAY DIFFRACTION	151	chain 'P' and (resid 1 through 10 )	P	1 - 10
152	X-RAY DIFFRACTION	152	chain 'P' and (resid 11 through 30 )	P	11 - 30
153	X-RAY DIFFRACTION	153	chain 'P' and (resid 31 through 40 )	P	31 - 40
154	X-RAY DIFFRACTION	154	chain 'P' and (resid 41 through 59 )	P	41 - 59
155	X-RAY DIFFRACTION	155	chain 'P' and (resid 60 through 80 )	P	60 - 80
156	X-RAY DIFFRACTION	156	chain 'P' and (resid 81 through 90 )	P	81 - 90
157	X-RAY DIFFRACTION	157	chain 'P' and (resid 91 through 102 )	P	91 - 102
158	X-RAY DIFFRACTION	158	chain 'P' and (resid 103 through 132 )	P	103 - 132
159	X-RAY DIFFRACTION	159	chain 'P' and (resid 133 through 141 )	P	133 - 141