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Yorodumi- PDB-5ugf: Crystal structure of human purine nucleoside phosphorylase (F159Y... -
+Open data
-Basic information
Entry | Database: PDB / ID: 5ugf | ||||||
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Title | Crystal structure of human purine nucleoside phosphorylase (F159Y) mutant complexed with DADMe-ImmG and phosphate | ||||||
Components | Purine nucleoside phosphorylase | ||||||
Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / phosphorylase / inhibitor / transition state analogue / purine salvage pathway / TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||
Function / homology | Function and homology information nicotinamide riboside catabolic process / Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine / purine-containing compound salvage / deoxyinosine catabolic process / purine nucleobase binding / inosine catabolic process / deoxyadenosine catabolic process / nucleotide biosynthetic process / dAMP catabolic process / urate biosynthetic process ...nicotinamide riboside catabolic process / Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine / purine-containing compound salvage / deoxyinosine catabolic process / purine nucleobase binding / inosine catabolic process / deoxyadenosine catabolic process / nucleotide biosynthetic process / dAMP catabolic process / urate biosynthetic process / Ribavirin ADME / IMP catabolic process / nucleoside binding / guanosine phosphorylase activity / Purine catabolism / allantoin metabolic process / Purine salvage / purine-nucleoside phosphorylase / nucleobase-containing compound metabolic process / purine ribonucleoside salvage / purine-nucleoside phosphorylase activity / positive regulation of alpha-beta T cell differentiation / phosphate ion binding / positive regulation of T cell proliferation / positive regulation of interleukin-2 production / secretory granule lumen / ficolin-1-rich granule lumen / response to xenobiotic stimulus / immune response / Neutrophil degranulation / extracellular exosome / extracellular region / identical protein binding / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.2 Å | ||||||
Authors | Harijan, R.K. / Cameron, S.A. / Bonanno, J.B. / Almo, S.C. / Schramm, V.L. | ||||||
Funding support | United States, 1items
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Citation | Journal: Proc. Natl. Acad. Sci. U.S.A. / Year: 2017 Title: Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase. Authors: Harijan, R.K. / Zoi, I. / Antoniou, D. / Schwartz, S.D. / Schramm, V.L. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5ugf.cif.gz | 364.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5ugf.ent.gz | 294.7 KB | Display | PDB format |
PDBx/mmJSON format | 5ugf.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 5ugf_validation.pdf.gz | 2.4 MB | Display | wwPDB validaton report |
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Full document | 5ugf_full_validation.pdf.gz | 2.5 MB | Display | |
Data in XML | 5ugf_validation.xml.gz | 67.7 KB | Display | |
Data in CIF | 5ugf_validation.cif.gz | 95.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ug/5ugf ftp://data.pdbj.org/pub/pdb/validation_reports/ug/5ugf | HTTPS FTP |
-Related structure data
Related structure data | 3phbS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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