登録情報 | データベース: PDB / ID: 5two |
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タイトル | Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selectively PPAR gamma-modulating ligand VSP-51 |
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要素 | - PRO-SER-LEU-LEU-LYS-LYS-LEU-LEU-LEU-ALA-PRO
- Peroxisome proliferator-activated receptor gamma
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キーワード | TRANSCRIPTION / Peroxisome proliferator-activated receptor gamma / lignad binding domain / selective PPAR gamma ligand / VSP-51 / DNA BINDING PROTEIN |
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機能・相同性 | 機能・相同性情報
Regulation of MITF-M dependent genes involved in metabolism / positive regulation of fatty acid oxidation / cellular respiration / prostaglandin receptor activity / : / negative regulation of receptor signaling pathway via STAT / MECP2 regulates transcription factors / negative regulation of vascular endothelial cell proliferation / negative regulation of extracellular matrix assembly / negative regulation of connective tissue replacement involved in inflammatory response wound healing ...Regulation of MITF-M dependent genes involved in metabolism / positive regulation of fatty acid oxidation / cellular respiration / prostaglandin receptor activity / : / negative regulation of receptor signaling pathway via STAT / MECP2 regulates transcription factors / negative regulation of vascular endothelial cell proliferation / negative regulation of extracellular matrix assembly / negative regulation of connective tissue replacement involved in inflammatory response wound healing / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / positive regulation of cholesterol transport / negative regulation of cellular response to transforming growth factor beta stimulus / arachidonate binding / positive regulation of adiponectin secretion / lipoprotein transport / DNA binding domain binding / negative regulation of cardiac muscle hypertrophy in response to stress / positive regulation of vascular associated smooth muscle cell apoptotic process / WW domain binding / positive regulation of fatty acid metabolic process / STAT family protein binding / response to lipid / temperature homeostasis / response to starvation / negative regulation of SMAD protein signal transduction / negative regulation of type II interferon-mediated signaling pathway / LBD domain binding / lncRNA binding / negative regulation of cholesterol storage / response to muscle activity / lipid homeostasis / E-box binding / intracellular glucose homeostasis / alpha-actinin binding / response to dietary excess / fatty acid oxidation / R-SMAD binding / energy homeostasis / negative regulation of vascular associated smooth muscle cell proliferation / monocyte differentiation / negative regulation of blood vessel endothelial cell migration / white fat cell differentiation / negative regulation of macrophage derived foam cell differentiation / negative regulation of lipid storage / cellular response to low-density lipoprotein particle stimulus / positive regulation of cholesterol efflux / negative regulation of BMP signaling pathway / cell fate commitment / negative regulation of osteoblast differentiation / negative regulation of mitochondrial fission / positive regulation of fat cell differentiation / adipose tissue development / BMP signaling pathway / long-chain fatty acid transport / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / nuclear retinoid X receptor binding / brown fat cell differentiation / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / retinoic acid receptor signaling pathway / cell maturation / negative regulation of MAPK cascade / intracellular receptor signaling pathway / digestion / hormone-mediated signaling pathway / positive regulation of adipose tissue development / response to nutrient / peroxisome proliferator activated receptor signaling pathway / epithelial cell differentiation / regulation of cellular response to insulin stimulus / positive regulation of gluconeogenesis / peptide binding / negative regulation of miRNA transcription / RNA splicing / SUMOylation of transcription cofactors / negative regulation of angiogenesis / placenta development / Regulation of PTEN gene transcription / positive regulation of apoptotic signaling pathway / nuclear receptor binding / transcription coregulator binding / gluconeogenesis / respiratory electron transport chain / mitochondrion organization / transcription coregulator activity / transcription initiation at RNA polymerase II promoter / negative regulation of smooth muscle cell proliferation / SUMOylation of intracellular receptors / negative regulation of transforming growth factor beta receptor signaling pathway / chromatin DNA binding / mRNA transcription by RNA polymerase II / circadian regulation of gene expression / fatty acid metabolic process / Heme signaling / Transcriptional activation of mitochondrial biogenesis / PPARA activates gene expression / regulation of circadian rhythm / PML body / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway類似検索 - 分子機能 PGC-1alpha, RNA recognition motif / PGC-1 / Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / Peroxisome proliferator-activated receptor / : / Retinoid X Receptor / Retinoid X Receptor / RNA recognition motif ...PGC-1alpha, RNA recognition motif / PGC-1 / Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / Peroxisome proliferator-activated receptor / : / Retinoid X Receptor / Retinoid X Receptor / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Double treble clef zinc finger, C4 type / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Nucleotide-binding alpha-beta plait domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-7MV / Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) unidentified (未定義) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.927 Å |
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データ登録者 | Yi, W. / Shi, J. / Zhao, G. / Zhou, X.E. / Suino-Powell, K. / Melcher, K. / Xu, H.E. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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Youth Innovation Promotion Association CAS, the Shanghai Municipal Natural Science Foundation | 15ZR1447800 | 中国 | the Chinese Postdoctoral Science Foundation | 2014M560363 | 中国 |
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引用 | ジャーナル: Sci Rep / 年: 2017 タイトル: Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro. 著者: Yi, W. / Shi, J. / Zhao, G. / Zhou, X.E. / Suino-Powell, K. / Melcher, K. / Xu, H.E. |
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履歴 | 登録 | 2016年11月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年2月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年10月24日 | Group: Data collection / Structure summary / カテゴリ: struct / Item: _struct.title |
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改定 1.2 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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