登録情報 データベース : PDB / ID : 5t4v 構造の表示 ダウンロードとリンクタイトル Crystal structure of the bromodomain of human BRPF1 in complex with NI-48 ligand 要素Peregrin 詳細 キーワード TRANSCRIPTION / Structural Genomics / Structural Genomics Consortium / SGC機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
acetyltransferase activator activity / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone acetyltransferase complex / Regulation of TP53 Activity through Acetylation / HATs acetylate histones / chromatin remodeling / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription ... acetyltransferase activator activity / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone acetyltransferase complex / Regulation of TP53 Activity through Acetylation / HATs acetylate histones / chromatin remodeling / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / regulation of DNA-templated transcription / DNA binding / nucleoplasm / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 BRPF1, PHD domain / Peregrin, ePHD domain / : / : / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. ... BRPF1, PHD domain / Peregrin, ePHD domain / : / : / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / domain with conserved PWWP motif / PWWP domain / PWWP domain profile. / PWWP domain / Zinc finger C2H2 type domain profile. / Zinc finger, PHD-type, conserved site / Zinc finger C2H2 type domain signature. / Zinc finger PHD-type signature. / Zinc finger C2H2-type / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Zinc finger, FYVE/PHD-type / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Bromodomain / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.65 Å 詳細データ登録者 Tallant, C. / Igoe, N. / Bayle, E.D. / Nunez-Alonso, G. / Newman, J.A. / Mathea, S. / Savitsky, P. / Fedorov, O. / Brennan, P.E. / Muller, S. ...Tallant, C. / Igoe, N. / Bayle, E.D. / Nunez-Alonso, G. / Newman, J.A. / Mathea, S. / Savitsky, P. / Fedorov, O. / Brennan, P.E. / Muller, S. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Fish, P. / Knapp, S. / Structural Genomics Consortium (SGC) 引用ジャーナル : J. Med. Chem. / 年 : 2017タイトル : Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.著者: Igoe, N. / Bayle, E.D. / Fedorov, O. / Tallant, C. / Savitsky, P. / Rogers, C. / Owen, D.R. / Deb, G. / Somervaille, T.C. / Andrews, D.M. / Jones, N. / Cheasty, A. / Ryder, H. / Brennan, P.E. ... 著者 : Igoe, N. / Bayle, E.D. / Fedorov, O. / Tallant, C. / Savitsky, P. / Rogers, C. / Owen, D.R. / Deb, G. / Somervaille, T.C. / Andrews, D.M. / Jones, N. / Cheasty, A. / Ryder, H. / Brennan, P.E. / Muller, S. / Knapp, S. / Fish, P.V. 履歴 登録 2016年8月30日 登録サイト : RCSB / 処理サイト : PDBE改定 1.0 2017年2月8日 Provider : repository / タイプ : Initial release改定 1.1 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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