Entry | Database: PDB / ID: 5t2r |
---|
Title | Unliganded Human HVEM at 2.1A in P 21 21 21 |
---|
Components | Tumor necrosis factor receptor superfamily member 14 |
---|
Keywords | IMMUNE SYSTEM / herpesvirus entry mediator / HVEM / TNFRSF14 |
---|
Function / homology | Function and homology information
negative regulation of adaptive immune memory response / negative regulation of alpha-beta T cell proliferation / tumor necrosis factor receptor activity / positive regulation of cytokine production involved in immune response / TNFs bind their physiological receptors / Costimulation by the CD28 family / cytokine binding / positive regulation of T cell migration / T cell costimulation / positive regulation of peptidyl-tyrosine phosphorylation ...negative regulation of adaptive immune memory response / negative regulation of alpha-beta T cell proliferation / tumor necrosis factor receptor activity / positive regulation of cytokine production involved in immune response / TNFs bind their physiological receptors / Costimulation by the CD28 family / cytokine binding / positive regulation of T cell migration / T cell costimulation / positive regulation of peptidyl-tyrosine phosphorylation / virus receptor activity / defense response to Gram-negative bacterium / adaptive immune response / cell surface receptor signaling pathway / defense response to Gram-positive bacterium / immune response / external side of plasma membrane / innate immune response / ubiquitin protein ligase binding / plasma membraneSimilarity search - Function Tumour necrosis factor receptor 14 / Tumor necrosis factor receptor 14/UL144, N-terminal / Tumor Necrosis Factor Receptor, subunit A, domain 2 / Tumor Necrosis Factor Receptor, subunit A; domain 2 / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Ribbon / Mainly BetaSimilarity search - Domain/homology |
---|
Biological species | Homo sapiens (human) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.1 Å |
---|
Authors | Nemcovicova, I. / Zajonc, D.M. |
---|
Funding support | Slovakia, 3items Organization | Grant number | Country |
---|
Slovak Research and Development Agency | APVV-14-0839 | Slovakia | Scientific Grant Agency of the Slovak Republic | 02/0103/15 | Slovakia | Marie Curie Action | SASPRO 0003/01/02 | Slovakia |
|
---|
Citation | Journal: To Be Published Title: Unliganded Human HVEM at 2.1A in P 21 21 21 Authors: Nemcovicova, I. / Zajonc, D.M. |
---|
History | Deposition | Aug 24, 2016 | Deposition site: RCSB / Processing site: PDBE |
---|
Revision 1.0 | Oct 24, 2018 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Jan 17, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|