Entry | Database: PDB / ID: 5syb |
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Title | Crystal structure of human PHF5A |
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Components | PHD finger-like domain-containing protein 5A |
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Keywords | TRANSCRIPTION / Core component / SF3B complex / human spliceosome |
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Function / homology | Function and homology information
U12-type spliceosomal complex / U2-type precatalytic spliceosome / U2-type spliceosomal complex / U2-type prespliceosome assembly / U2 snRNP / precatalytic spliceosome / mRNA Splicing - Major Pathway / stem cell differentiation / spliceosomal complex / nuclear matrix ...U12-type spliceosomal complex / U2-type precatalytic spliceosome / U2-type spliceosomal complex / U2-type prespliceosome assembly / U2 snRNP / precatalytic spliceosome / mRNA Splicing - Major Pathway / stem cell differentiation / spliceosomal complex / nuclear matrix / mRNA splicing, via spliceosome / nuclear speck / positive regulation of DNA-templated transcription / DNA binding / RNA binding / zinc ion binding / nucleoplasm / nucleusSimilarity search - Function |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution: 1.82 Å |
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Authors | Tsai, J.H.C. / Teng, T. / Zhu, P. / Fekkes, P. / Larsen, N.A. |
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Citation | Journal: Nat Commun / Year: 2017 Title: Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex. Authors: Teng, T. / Tsai, J.H. / Puyang, X. / Seiler, M. / Peng, S. / Prajapati, S. / Aird, D. / Buonamici, S. / Caleb, B. / Chan, B. / Corson, L. / Feala, J. / Fekkes, P. / Gerard, B. / Karr, C. / ...Authors: Teng, T. / Tsai, J.H. / Puyang, X. / Seiler, M. / Peng, S. / Prajapati, S. / Aird, D. / Buonamici, S. / Caleb, B. / Chan, B. / Corson, L. / Feala, J. / Fekkes, P. / Gerard, B. / Karr, C. / Korpal, M. / Liu, X. / T Lowe, J. / Mizui, Y. / Palacino, J. / Park, E. / Smith, P.G. / Subramanian, V. / Wu, Z.J. / Zou, J. / Yu, L. / Chicas, A. / Warmuth, M. / Larsen, N. / Zhu, P. |
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History | Deposition | Aug 10, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Sep 7, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 26, 2016 | Group: Structure summary |
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Revision 1.2 | Jun 7, 2017 | Group: Database references |
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Revision 1.3 | Mar 6, 2024 | Group: Data collection / Database references Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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