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TitleSplicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Journal, issue, pagesNat Commun, Vol. 8, Page 15522-15522, Year 2017
Publish dateAug 10, 2016 (structure data deposition date)
AuthorsTeng, T. / Tsai, J.H. / Puyang, X. / Seiler, M. / Peng, S. / Prajapati, S. / Aird, D. / Buonamici, S. / Caleb, B. / Chan, B. ...Teng, T. / Tsai, J.H. / Puyang, X. / Seiler, M. / Peng, S. / Prajapati, S. / Aird, D. / Buonamici, S. / Caleb, B. / Chan, B. / Corson, L. / Feala, J. / Fekkes, P. / Gerard, B. / Karr, C. / Korpal, M. / Liu, X. / T Lowe, J. / Mizui, Y. / Palacino, J. / Park, E. / Smith, P.G. / Subramanian, V. / Wu, Z.J. / Zou, J. / Yu, L. / Chicas, A. / Warmuth, M. / Larsen, N. / Zhu, P.
External linksNat Commun / PubMed:28541300
MethodsX-ray diffraction
Resolution1.82 Å
Structure data

PDB-5syb:
Crystal structure of human PHF5A
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Core component / SF3B complex / human spliceosome

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