Entry | Database: PDB / ID: 5scp |
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Title | Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-23 |
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Components | Dihydrofolate reductase |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Mycobacterium tuberculosis / DHFR / NADP / Folate / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / SSGCID |
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Function / homology | Function and homology information
NADP+ binding / dihydrofolate metabolic process / glycine biosynthetic process / dihydrofolate reductase / dihydrofolate reductase activity / folic acid metabolic process / tetrahydrofolate biosynthetic process / one-carbon metabolic process / NADP binding / cytosolSimilarity search - Function Dihydrofolate reductase / Dihydrofolate reductase conserved site / Dihydrofolate reductase (DHFR) domain signature. / Dihydrofolate reductase domain / Dihydrofolate reductase / Dihydrofolate reductase (DHFR) domain profile. / Dihydrofolate reductase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | Mycobacterium tuberculosis H37Rv (bacteria) |
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Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 1.8 Å |
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Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | HHSN272201700059C | United States |
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Citation | Journal: to be published Title: Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-23 Authors: Mayclin, S.J. / Fairman, J.W. / Dranow, D.M. / Conrady, D.G. / Fox III, D. / Lukacs, C.M. / Lorimer, D.D. / Horanyi, P.S. / Edwards, T.E. / Abendroth, J. |
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History | Deposition | Dec 20, 2021 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Feb 9, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 2, 2022 | Group: Other / Structure summary Category: pdbx_SG_project / pdbx_database_status / struct_keywords Item: _pdbx_database_status.SG_entry / _struct_keywords.text |
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Revision 1.2 | May 22, 2024 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond |
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