coagulation factor VIIa / response to Thyroid stimulating hormone / response to 2,3,7,8-tetrachlorodibenzodioxine / response to astaxanthin / response to thyrotropin-releasing hormone / response to genistein / serine-type peptidase complex / positive regulation of platelet-derived growth factor receptor signaling pathway / response to vitamin K / response to carbon dioxide ...coagulation factor VIIa / response to Thyroid stimulating hormone / response to 2,3,7,8-tetrachlorodibenzodioxine / response to astaxanthin / response to thyrotropin-releasing hormone / response to genistein / serine-type peptidase complex / positive regulation of platelet-derived growth factor receptor signaling pathway / response to vitamin K / response to carbon dioxide / response to thyroxine / response to cholesterol / response to growth hormone / positive regulation of positive chemotaxis / Extrinsic Pathway of Fibrin Clot Formation / positive regulation of leukocyte chemotaxis / positive regulation of TOR signaling / positive regulation of blood coagulation / animal organ regeneration / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Removal of aminoterminal propeptides from gamma-carboxylated proteins / serine-type peptidase activity / BMAL1:CLOCK,NPAS2 activates circadian gene expression / protein processing / Golgi lumen / 概日リズム / response to estrogen / 凝固・線溶系 / response to estradiol / collagen-containing extracellular matrix / vesicle / response to hypoxia / positive regulation of cell migration / 小胞体 / signaling receptor binding / serine-type endopeptidase activity / calcium ion binding / extracellular space / extracellular region / 細胞膜 類似検索 - 分子機能
構造決定の手法: 分子置換 開始モデル: inhouse model 解像度: 1.6→49.63 Å / Cor.coef. Fo:Fc: 0.966 / Cor.coef. Fo:Fc free: 0.956 / SU B: 1.36 / SU ML: 0.046 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.064 / ESU R Free: 0.065 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: the numbering follows that of the unprocessed precursor. from a mixture of 4 diastereomers only the R,R-enantiomer binds. two residues - lys401 and cys428 - have strained main- chain angles. ...詳細: the numbering follows that of the unprocessed precursor. from a mixture of 4 diastereomers only the R,R-enantiomer binds. two residues - lys401 and cys428 - have strained main- chain angles. there are close contacts between the carbonyl group of gly427 and carbon atoms of the aminoisoquinoline. the region 426-429 seems to be mobile as judged by slightly elevated B-values and spurious Fo-Fc peaks flanking the main-chain. HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
Rfactor
反射数
%反射
Selection details
Rfree
0.19
3507
5.1 %
RANDOM
Rwork
0.1699
-
-
-
obs
0.1709
65911
98.62 %
-
溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK