登録情報 | データベース: PDB / ID: 5ojk |
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タイトル | Crystal structure of the human neuroligin 1 cholinesterase domain containing spliced sequence B (SSB) (NL1(-A+B)) |
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要素 | Neuroligin-1,Neuroligin-1 |
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キーワード | CELL ADHESION / neuroligin-neurexin / synaptic organizer protein / spliced sequence B |
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機能・相同性 | 機能・相同性情報
asymmetric, glutamatergic, excitatory synapse / neurexin clustering involved in presynaptic membrane assembly / cytoskeletal matrix organization at active zone / positive regulation of synaptic vesicle exocytosis / positive regulation of circadian sleep/wake cycle, wakefulness / negative regulation of dendritic spine morphogenesis / protein complex involved in cell-cell adhesion / positive regulation of neuromuscular synaptic transmission / neuronal signal transduction / terminal button organization ...asymmetric, glutamatergic, excitatory synapse / neurexin clustering involved in presynaptic membrane assembly / cytoskeletal matrix organization at active zone / positive regulation of synaptic vesicle exocytosis / positive regulation of circadian sleep/wake cycle, wakefulness / negative regulation of dendritic spine morphogenesis / protein complex involved in cell-cell adhesion / positive regulation of neuromuscular synaptic transmission / neuronal signal transduction / terminal button organization / postsynaptic density protein 95 clustering / excitatory synapse assembly / postsynaptic membrane assembly / presynaptic membrane assembly / neurexin family protein binding / synaptic vesicle targeting / presynapse assembly / synaptic vesicle clustering / receptor localization to synapse / filopodium tip / neuron cell-cell adhesion / NMDA glutamate receptor clustering / positive regulation of synaptic vesicle endocytosis / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / neuron projection arborization / AMPA glutamate receptor clustering / regulation of AMPA receptor activity / protein localization to synapse / regulation of NMDA receptor activity / positive regulation of synapse assembly / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / positive regulation of ruffle assembly / positive regulation of filopodium assembly / regulation of neuron differentiation / Neurexins and neuroligins / postsynaptic specialization membrane / positive regulation of dendritic spine development / positive regulation of intracellular signal transduction / neuron projection morphogenesis / excitatory synapse / positive regulation of excitatory postsynaptic potential / positive regulation of synaptic transmission, glutamatergic / synaptic cleft / protein targeting / cell adhesion molecule binding / synapse assembly / cellular response to calcium ion / positive regulation of synaptic transmission, GABAergic / PDZ domain binding / neuromuscular junction / establishment of protein localization / modulation of chemical synaptic transmission / GABA-ergic synapse / neuron projection development / rhythmic process / nervous system development / presynapse / signaling receptor activity / amyloid-beta binding / scaffold protein binding / dendritic spine / postsynaptic membrane / receptor complex / postsynapse / postsynaptic density / dendrite / synapse / glutamatergic synapse / cell surface / Golgi apparatus / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Neuroligin / : / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase, type B / Carboxylesterase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.55 Å |
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データ登録者 | Elegheert, J. / Aricescu, A.R. |
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資金援助 | 英国, カナダ, 米国, 13件 組織 | 認可番号 | 国 |
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Medical Research Council (United Kingdom) | G0700232 | 英国 | Medical Research Council (United Kingdom) | L009609 | 英国 | Medical Research Council (United Kingdom) | MC_UP_1201/15 | 英国 | CIHR | FDN-143206 | カナダ | CIHR | NDD-144222 | カナダ | National Institutes of Health | R00 DC013805 | 米国 | European Molecular Biology Organization | ALTF 1116-2012 | 英国 | Marie Curie | FP7-328531 | 英国 | Cancer Research UK | C375/A10976 | 英国 | National Institutes of Health | MH085926 | 米国 | National Institutes of Health | GM105730 | 米国 | National Institutes of Health | F32NS093753 | 米国 | Wellcome Trust | 090532/Z/09/Z | 英国 |
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引用 | ジャーナル: Neuron / 年: 2017 タイトル: Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. 著者: Elegheert, J. / Cvetkovska, V. / Clayton, A.J. / Heroven, C. / Vennekens, K.M. / Smukowski, S.N. / Regan, M.C. / Jia, W. / Smith, A.C. / Furukawa, H. / Savas, J.N. / de Wit, J. / Begbie, J. / ...著者: Elegheert, J. / Cvetkovska, V. / Clayton, A.J. / Heroven, C. / Vennekens, K.M. / Smukowski, S.N. / Regan, M.C. / Jia, W. / Smith, A.C. / Furukawa, H. / Savas, J.N. / de Wit, J. / Begbie, J. / Craig, A.M. / Aricescu, A.R. |
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履歴 | 登録 | 2017年7月21日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2017年8月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年8月30日 | Group: Database references / カテゴリ: citation Item: _citation.journal_id_ISSN / _citation.page_last ..._citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2018年1月31日 | Group: Structure summary / カテゴリ: audit_author / Item: _audit_author.name |
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改定 1.3 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.4 | 2024年1月17日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.5 | 2024年10月23日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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