登録情報 データベース : PDB / ID : 5oi3 構造の表示 ダウンロードとリンクタイトル Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 要素Integrase 詳細 キーワード VIRAL PROTEIN / HIV-1 / Integrase / Catalytic core domain機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
HIV-1 retropepsin / symbiont-mediated activation of host apoptosis / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency ... HIV-1 retropepsin / symbiont-mediated activation of host apoptosis / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency / symbiont-mediated suppression of host gene expression / viral penetration into host nucleus / RNA stem-loop binding / RNA-directed DNA polymerase activity / RNA-DNA hybrid ribonuclease activity / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / host cell / viral nucleocapsid / endonuclease activity / DNA recombination / DNA-directed DNA polymerase / 加水分解酵素; エステル加水分解酵素 / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / viral translational frameshifting / symbiont entry into host cell / lipid binding / host cell nucleus / host cell plasma membrane / structural molecule activity / virion membrane / proteolysis / DNA binding / zinc ion binding / membrane 類似検索 - 分子機能 Ribonuclease H-like superfamily/Ribonuclease H / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral ... Ribonuclease H-like superfamily/Ribonuclease H / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain / Integrase, C-terminal, retroviral / Integrase DNA binding domain profile. / Immunodeficiency lentiviral matrix, N-terminal / gag gene protein p17 (matrix protein) / RNase H / Integrase core domain / Integrase, catalytic core / Integrase catalytic domain profile. / Retropepsin-like catalytic domain / Matrix protein, lentiviral and alpha-retroviral, N-terminal / RNase H type-1 domain profile. / Ribonuclease H domain / Retroviral nucleocapsid Gag protein p24, C-terminal domain / Gag protein p24 C-terminal domain / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Reverse transcriptase (RNA-dependent DNA polymerase) / Peptidase A2A, retrovirus, catalytic / Retroviral matrix protein / Retrovirus capsid, C-terminal / Retrovirus capsid, N-terminal / zinc finger / Zinc knuckle / Zinc finger, CCHC-type superfamily / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Nucleotidyltransferase; domain 5 / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Ribonuclease H superfamily / Aspartic peptidase domain superfamily / Ribonuclease H-like superfamily / Reverse transcriptase/Diguanylate cyclase domain / DNA/RNA polymerase superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Human immunodeficiency virus 1 (ヒト免疫不全ウイルス)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.3 Å 詳細データ登録者 Ruff, M. / Benarous, R. 引用ジャーナル : J. Biol. Chem. / 年 : 2018タイトル : Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.著者: Bonnard, D. / Le Rouzic, E. / Eiler, S. / Amadori, C. / Orlov, I. / Bruneau, J.M. / Brias, J. / Barbion, J. / Chevreuil, F. / Spehner, D. / Chasset, S. / Ledoussal, B. / Moreau, F. / Saib, A. ... 著者 : Bonnard, D. / Le Rouzic, E. / Eiler, S. / Amadori, C. / Orlov, I. / Bruneau, J.M. / Brias, J. / Barbion, J. / Chevreuil, F. / Spehner, D. / Chasset, S. / Ledoussal, B. / Moreau, F. / Saib, A. / Klaholz, B.P. / Emiliani, S. / Ruff, M. / Zamborlini, A. / Benarous, R. 履歴 登録 2017年7月18日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2018年3月7日 Provider : repository / タイプ : Initial release改定 1.1 2018年3月14日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2018年5月2日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2019年10月16日 Group : Data collection / カテゴリ : reflns_shell改定 1.4 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession改定 1.5 2024年10月9日 Group : Structure summaryカテゴリ : pdbx_entry_details / pdbx_modification_feature
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