登録情報 | データベース: PDB / ID: 5o9h |
---|
タイトル | Crystal structure of thermostabilised human C5a anaphylatoxin chemotactic receptor 1 (C5aR) in complex with NDT9513727 |
---|
要素 | C5a anaphylatoxin chemotactic receptor 1 |
---|
キーワード | MEMBRANE PROTEIN / GPCR / 7TM / SIGNALLING PROTEIN |
---|
機能・相同性 | 機能・相同性情報
complement component C5a signaling pathway / presynapse organization / regulation of tau-protein kinase activity / complement component C5a receptor activity / response to peptidoglycan / sensory perception of chemical stimulus / complement receptor mediated signaling pathway / positive regulation of neutrophil chemotaxis / positive regulation of macrophage chemotaxis / amyloid-beta clearance ...complement component C5a signaling pathway / presynapse organization / regulation of tau-protein kinase activity / complement component C5a receptor activity / response to peptidoglycan / sensory perception of chemical stimulus / complement receptor mediated signaling pathway / positive regulation of neutrophil chemotaxis / positive regulation of macrophage chemotaxis / amyloid-beta clearance / : / positive regulation of vascular endothelial growth factor production / cellular defense response / Peptide ligand-binding receptors / neutrophil chemotaxis / secretory granule membrane / Regulation of Complement cascade / positive regulation of epithelial cell proliferation / G protein-coupled receptor activity / astrocyte activation / microglial cell activation / mRNA transcription by RNA polymerase II / cognition / positive regulation of angiogenesis / chemotaxis / apical part of cell / phospholipase C-activating G protein-coupled receptor signaling pathway / G alpha (i) signalling events / positive regulation of cytosolic calcium ion concentration / basolateral plasma membrane / positive regulation of ERK1 and ERK2 cascade / defense response to Gram-positive bacterium / inflammatory response / immune response / Neutrophil degranulation / signal transduction / plasma membrane類似検索 - 分子機能 Anaphylatoxin chemotactic receptor, C3a/C5a1/C5a2 / Formyl peptide receptor-related / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 Chem-9P2 / CITRIC ACID / OLEIC ACID / L(+)-TARTARIC ACID / C5a anaphylatoxin chemotactic receptor 1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.7 Å |
---|
データ登録者 | Robertson, N. / Rappas, M. / Dore, A.S. / Brown, J. / Bottegoni, G. / Koglin, M. / Cansfield, J. / Jazayeri, A. / Cooke, R.M. / Marshall, F.H. |
---|
引用 | ジャーナル: Nature / 年: 2018 タイトル: Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727. 著者: Robertson, N. / Rappas, M. / Dore, A.S. / Brown, J. / Bottegoni, G. / Koglin, M. / Cansfield, J. / Jazayeri, A. / Cooke, R.M. / Marshall, F.H. |
---|
履歴 | 登録 | 2017年6月19日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2018年1月10日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2018年1月17日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
---|
改定 1.2 | 2018年1月31日 | Group: Database references / Source and taxonomy / カテゴリ: entity_src_gen / pdbx_related_exp_data_set / Item: _entity_src_gen.host_org_common_name |
---|
改定 1.3 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|