- PDB-5o6h: Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917 -
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Open data
ID or keywords:
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Basic information
Entry
Database: PDB / ID: 5o6h
Title
Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917
Components
Glycylpeptide N-tetradecanoyltransferase 1
Keywords
TRANSFERASE / Myristoyl / inhibitor
Function / homology
Function and homology information
myristoyltransferase activity / peptidyl-lysine N6-myristoyltransferase activity / N-terminal peptidyl-glycine N-myristoylation / Late Phase of HIV Life Cycle / cellular ketone metabolic process / regulation of opsin-mediated signaling pathway / Activation, myristolyation of BID and translocation to mitochondria / glycylpeptide N-tetradecanoyltransferase / glycylpeptide N-tetradecanoyltransferase activity / protein localization to membrane ...myristoyltransferase activity / peptidyl-lysine N6-myristoyltransferase activity / N-terminal peptidyl-glycine N-myristoylation / Late Phase of HIV Life Cycle / cellular ketone metabolic process / regulation of opsin-mediated signaling pathway / Activation, myristolyation of BID and translocation to mitochondria / glycylpeptide N-tetradecanoyltransferase / glycylpeptide N-tetradecanoyltransferase activity / protein localization to membrane / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / Inactivation, recovery and regulation of the phototransduction cascade / in utero embryonic development / plasma membrane / cytoplasm / cytosol Similarity search - Function
Resolution: 1.29→55 Å / Cor.coef. Fo:Fc: 0.973 / Cor.coef. Fo:Fc free: 0.963 / SU B: 0.965 / SU ML: 0.04 / Cross valid method: THROUGHOUT / ESU R: 0.047 / ESU R Free: 0.051 / Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.19348
10300
5 %
RANDOM
Rwork
0.16384
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obs
0.16533
195765
98.68 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å