Entry Database : PDB / ID : 5nqh Structure visualization Downloads & linksTitle Structure of the human Fe65-PTB2 homodimer ComponentsAmyloid beta A4 precursor protein-binding family B member 1 Details Keywords SIGNALING PROTEIN / Alzheimers disease / phosphotyrosine-binding (PTB) domain / homodimerizationFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of cell cycle G1/S phase transition / proline-rich region binding / low-density lipoprotein particle receptor binding / smooth muscle contraction / axonogenesis / positive regulation of protein secretion / positive regulation of neuron projection development / lamellipodium / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / chromatin organization ... negative regulation of cell cycle G1/S phase transition / proline-rich region binding / low-density lipoprotein particle receptor binding / smooth muscle contraction / axonogenesis / positive regulation of protein secretion / positive regulation of neuron projection development / lamellipodium / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / chromatin organization / amyloid-beta binding / histone binding / growth cone / molecular adaptor activity / transcription coactivator activity / nuclear speck / positive regulation of apoptotic process / apoptotic process / ubiquitin protein ligase binding / synapse / DNA damage response / chromatin binding / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / plasma membrane / cytoplasm Similarity search - Function Amyloid beta precursor protein binding family B member 1/2/3 / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues ... Amyloid beta precursor protein binding family B member 1/2/3 / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / WW domain / PH-domain like / PH-like domain superfamily / Roll / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.6 Å DetailsAuthors Feilen, L.P. / Haubrich, K. / Sinning, I. / Konietzko, U. / Kins, S. / Simon, B. / Wild, K. CitationJournal : Front Mol Neurosci / Year : 2017Title : Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction.Authors : Feilen, L.P. / Haubrich, K. / Strecker, P. / Probst, S. / Eggert, S. / Stier, G. / Sinning, I. / Konietzko, U. / Kins, S. / Simon, B. / Wild, K. History Deposition Apr 20, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 3, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jun 7, 2017 Group : Database referencesRevision 1.2 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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