Entry Database : PDB / ID : 5nlb Structure visualization Downloads & linksTitle Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box ComponentsCullin-3 Kelch-like ECH-associated protein 1 DetailsKeywords LIGASE / E3 ubiquitin ligaseFunction / homology Function and homology informationFunction Domain/homology Component
liver morphogenesis / positive regulation of mitotic cell cycle phase transition / trophectodermal cellular morphogenesis / POZ domain binding / nuclear protein quality control by the ubiquitin-proteasome system / regulation protein catabolic process at postsynapse / polar microtubule / anaphase-promoting complex-dependent catabolic process / COPII vesicle coating / stem cell division ... liver morphogenesis / positive regulation of mitotic cell cycle phase transition / trophectodermal cellular morphogenesis / POZ domain binding / nuclear protein quality control by the ubiquitin-proteasome system / regulation protein catabolic process at postsynapse / polar microtubule / anaphase-promoting complex-dependent catabolic process / COPII vesicle coating / stem cell division / regulation of epidermal cell differentiation / RHOBTB3 ATPase cycle / embryonic cleavage / cell projection organization / positive regulation of mitotic metaphase/anaphase transition / Notch binding / RHOBTB1 GTPase cycle / negative regulation of response to oxidative stress / Nuclear events mediated by NFE2L2 / fibroblast apoptotic process / negative regulation of Rho protein signal transduction / negative regulation of type I interferon production / ubiquitin ligase complex scaffold activity / mitotic metaphase chromosome alignment / Cul3-RING ubiquitin ligase complex / stress fiber assembly / positive regulation of cytokinesis / protein monoubiquitination / ubiquitin-like ligase-substrate adaptor activity / centriolar satellite / sperm flagellum / protein autoubiquitination / cellular response to interleukin-4 / RHOBTB2 GTPase cycle / protein K48-linked ubiquitination / endoplasmic reticulum to Golgi vesicle-mediated transport / inclusion body / gastrulation / positive regulation of TORC1 signaling / intrinsic apoptotic signaling pathway / cyclin binding / positive regulation of protein ubiquitination / regulation of autophagy / integrin-mediated signaling pathway / Degradation of DVL / actin filament / cellular response to amino acid stimulus / Hedgehog 'on' state / protein destabilization / negative regulation of DNA-binding transcription factor activity / mitotic spindle / Wnt signaling pathway / spindle pole / G1/S transition of mitotic cell cycle / Regulation of RAS by GAPs / protein polyubiquitination / KEAP1-NFE2L2 pathway / ubiquitin protein ligase activity / disordered domain specific binding / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / cell migration / Neddylation / gene expression / midbody / cellular response to oxidative stress / ubiquitin-dependent protein catabolic process / postsynapse / proteasome-mediated ubiquitin-dependent protein catabolic process / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / Potential therapeutics for SARS / Ub-specific processing proteases / protein ubiquitination / inflammatory response / centrosome / glutamatergic synapse / ubiquitin protein ligase binding / positive regulation of cell population proliferation / Golgi apparatus / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / extracellular exosome / nucleoplasm / identical protein binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Cullin Repeats / 5 helical Cullin repeat like / Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / Cullin protein neddylation domain / BTB And C-terminal Kelch / Cullin, conserved site ... Cullin Repeats / 5 helical Cullin repeat like / Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / Cullin protein neddylation domain / BTB And C-terminal Kelch / Cullin, conserved site / Cullin family signature. / Cullin / Cullin repeat-like-containing domain superfamily / Cullin protein, neddylation domain / Cullin protein neddylation domain / Kelch / Kelch repeat type 1 / Kelch motif / Cullin / Cullin, N-terminal / Cullin homology domain / Cullin homology domain superfamily / Cullin family / Cullin family profile. / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / SKP1/BTB/POZ domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.45 Å DetailsAuthors Adamson, R. / Krojer, T. / Pinkas, D.M. / Bartual, S.G. / Burgess-Brown, N.A. / Borkowska, O. / Chalk, R. / Newman, J.A. / Kopec, J. / Dixon-Clarke, S.E. ...Adamson, R. / Krojer, T. / Pinkas, D.M. / Bartual, S.G. / Burgess-Brown, N.A. / Borkowska, O. / Chalk, R. / Newman, J.A. / Kopec, J. / Dixon-Clarke, S.E. / Mathea, S. / Sethi, R. / Velupillai, S. / Mackinnon, S. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Bullock, A. CitationJournal : Free Radic Biol Med / Year : 2023Title : Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.Authors : Adamson, R.J. / Payne, N.C. / Bartual, S.G. / Mazitschek, R. / Bullock, A.N. History Deposition Apr 4, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 19, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Aug 2, 2017 Group : Database references / Structure summary / Category : audit_author / citation_author / Item : _audit_author.name / _citation_author.nameRevision 1.2 Oct 16, 2019 Group : Data collection / Category : reflns_shellRevision 1.3 Nov 8, 2023 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / citation_author / database_2 Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession Revision 1.4 Jan 17, 2024 Group : Refinement description / Category : pdbx_initial_refinement_model
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