Entry Database : PDB / ID : 5m5g Structure visualization Downloads & linksTitle Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2) ComponentsFragment from molecular 2 (region containing putative polycomb protein Suz12) HISTONE H3 11-Mer peptide Putative uncharacterized protein putative polycomb protein EED DetailsKeywords TRANSFERASE / REPRESSIVE / COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
histone H3K27 methyltransferase activity / ESC/E(Z) complex / RSC-type complex / Chromatin modifying enzymes / heterochromatin formation / epigenetic regulation of gene expression / nucleosome binding / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling ... histone H3K27 methyltransferase activity / ESC/E(Z) complex / RSC-type complex / Chromatin modifying enzymes / heterochromatin formation / epigenetic regulation of gene expression / nucleosome binding / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling / Assembly of the ORC complex at the origin of replication / DNA methylation / Condensation of Prophase Chromosomes / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / SIRT1 negatively regulates rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / HCMV Late Events / PRC2 methylates histones and DNA / Defective pyroptosis / HDACs deacetylate histones / RNA Polymerase I Promoter Escape / Transcriptional regulation by small RNAs / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / NoRC negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / B-WICH complex positively regulates rRNA expression / HDMs demethylate histones / chromatin DNA binding / PKMTs methylate histone lysines / Meiotic recombination / RMTs methylate histone arginines / Pre-NOTCH Transcription and Translation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / nucleosome / nucleosome assembly / chromatin organization / RUNX1 regulates transcription of genes involved in differentiation of HSCs / Factors involved in megakaryocyte development and platelet production / HATs acetylate histones / gene expression / Senescence-Associated Secretory Phenotype (SASP) / methylation / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / cadherin binding / protein heterodimerization activity / Amyloid fiber formation / chromatin binding / negative regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / metal ion binding Similarity search - Function EZH2, N-terminal domain / MCSS domain / : / Fungal MCSS domain / EZH2 N-terminal domain / Fungal polycomb repressive complex 2, Ezh2-like, preSET CXC domain / Polycomb protein, VEFS-Box / VEFS-Box of polycomb protein / Histone-lysine N-methyltransferase EZH1/2-like / CXC domain ... EZH2, N-terminal domain / MCSS domain / : / Fungal MCSS domain / EZH2 N-terminal domain / Fungal polycomb repressive complex 2, Ezh2-like, preSET CXC domain / Polycomb protein, VEFS-Box / VEFS-Box of polycomb protein / Histone-lysine N-methyltransferase EZH1/2-like / CXC domain / CXC domain profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Histone H3 signature 1. / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Histone-fold / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily Similarity search - Domain/homology S-ADENOSYL-L-HOMOCYSTEINE / Zinc finger domain-containing protein / Uncharacterized protein / SET domain-containing protein / Histone H3.1 Similarity search - ComponentBiological species Chaetomium thermophilum (fungus)Chaetomium thermophilum var. thermophilum DSM 1495 (fungus)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.27 Å DetailsAuthors Zhang, Y. / Justin, N. / Wilson, J. / Gamblin, S. Citation Show more 1 items Show less#1: Journal : Science / Year : 2015Title : Structural Basis Of Histone H3K27 Trimethylation By An Active Polycomb Repressive Complex 2.
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Jiao, L. / Liu, X. History Deposition Oct 21, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 11, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Oct 16, 2019 Group : Data collection / Category : reflns_shell
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