Entry Database : PDB / ID : 5m37 Structure visualization Downloads & linksTitle The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Components14-3-3 protein zeta/delta M-phase inducer phosphatase 3 DetailsKeywords HYDROLASE / Stabilization / 14-3-3 / disordered PPI interface / CDC25CFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of G2/MI transition of meiotic cell cycle / Golgi reassembly / synaptic target recognition / WW domain binding / respiratory system process / NOTCH4 Activation and Transmission of Signal to the Nucleus / regulation of synapse maturation / establishment of Golgi localization / tube formation / Rap1 signalling ... positive regulation of G2/MI transition of meiotic cell cycle / Golgi reassembly / synaptic target recognition / WW domain binding / respiratory system process / NOTCH4 Activation and Transmission of Signal to the Nucleus / regulation of synapse maturation / establishment of Golgi localization / tube formation / Rap1 signalling / Polo-like kinase mediated events / negative regulation of protein localization to nucleus / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / KSRP (KHSRP) binds and destabilizes mRNA / regulation of mitotic nuclear division / regulation of cyclin-dependent protein serine/threonine kinase activity / GP1b-IX-V activation signalling / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / phosphoprotein phosphatase activity / Regulation of localization of FOXO transcription factors / Interleukin-3, Interleukin-5 and GM-CSF signaling / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / protein targeting / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to glucose starvation / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / Activation of ATR in response to replication stress / Cyclin A/B1/B2 associated events during G2/M transition / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / RHO GTPases activate PKNs / negative regulation of TORC1 signaling / protein sequestering activity / positive regulation of G2/M transition of mitotic cell cycle / ERK1 and ERK2 cascade / negative regulation of innate immune response / hippocampal mossy fiber to CA3 synapse / protein-tyrosine-phosphatase / regulation of ERK1 and ERK2 cascade / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / protein tyrosine phosphatase activity / Translocation of SLC2A4 (GLUT4) to the plasma membrane / Deactivation of the beta-catenin transactivating complex / TP53 Regulates Metabolic Genes / Negative regulation of NOTCH4 signaling / lung development / regulation of protein stability / mitochondrial intermembrane space / G2/M transition of mitotic cell cycle / melanosome / spermatogenesis / angiogenesis / DNA-binding transcription factor binding / vesicle / transmembrane transporter binding / cell population proliferation / blood microparticle / cadherin binding / protein domain specific binding / cell division / protein phosphorylation / focal adhesion / glutamatergic synapse / ubiquitin protein ligase binding / negative regulation of apoptotic process / protein kinase binding / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / signal transduction / RNA binding / extracellular space / extracellular exosome / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function M-phase inducer phosphatase / M-phase inducer phosphatase / Rhodanese Homology Domain / Rhodanese-like domain / Rhodanese domain profile. / 14-3-3 domain / Rhodanese-like domain superfamily / Rhodanese-like domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. ... M-phase inducer phosphatase / M-phase inducer phosphatase / Rhodanese Homology Domain / Rhodanese-like domain / Rhodanese domain profile. / 14-3-3 domain / Rhodanese-like domain superfamily / Rhodanese-like domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.35 Å DetailsAuthors Bier, D. / Ottmann, C. Funding support Germany, Netherlands, 3items Details Hide detailsOrganization Grant number Country German Research Foundation Collaborative Research Centre 1093 Germany Netherlands Organisation for Scientific Research 024.001.035 Netherlands Netherlands Organisation for Scientific Research 016.150.366 Netherlands
CitationJournal : J. Am. Chem. Soc. / Year : 2017Title : The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.Authors : Bier, D. / Mittal, S. / Bravo-Rodriguez, K. / Sowislok, A. / Guillory, X. / Briels, J. / Heid, C. / Bartel, M. / Wettig, B. / Brunsveld, L. / Sanchez-Garcia, E. / Schrader, T. / Ottmann, C. History Deposition Oct 14, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 15, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Nov 22, 2017 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.2 Dec 12, 2018 Group : Data collection / Derived calculations / Category : struct_connRevision 1.3 Jan 10, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly Item : _chem_comp.name / _database_2.pdbx_DOI ... _chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name Revision 1.4 Jan 17, 2024 Group : Refinement description / Category : pdbx_initial_refinement_model
Show all Show less