Entry Database : PDB / ID : 5lgd Structure visualization Downloads & linksTitle The CIDRa domain from MCvar1 PfEMP1 bound to CD36 ComponentsPfEMP1 variant 1 of strain MC Platelet glycoprotein 4 DetailsKeywords CELL ADHESION / Plasmodium falciparum cytoadhesion scavenger receptor malariaFunction / homology Function and homology informationFunction Domain/homology Component
short-chain fatty acid transmembrane transporter activity / short-chain fatty acid transport / lipoteichoic acid immune receptor activity / oxidised low-density lipoprotein particle clearance / oxidised low-density lipoprotein particle receptor activity / Intracellular metabolism of fatty acids regulates insulin secretion / long-chain fatty acid import across plasma membrane / response to linoleic acid / oleate transmembrane transporter activity / toll-like receptor TLR6:TLR2 signaling pathway ... short-chain fatty acid transmembrane transporter activity / short-chain fatty acid transport / lipoteichoic acid immune receptor activity / oxidised low-density lipoprotein particle clearance / oxidised low-density lipoprotein particle receptor activity / Intracellular metabolism of fatty acids regulates insulin secretion / long-chain fatty acid import across plasma membrane / response to linoleic acid / oleate transmembrane transporter activity / toll-like receptor TLR6:TLR2 signaling pathway / Toll Like Receptor TLR6:TLR2 Cascade / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / low-density lipoprotein particle mediated signaling / cellular response to diacyl bacterial lipopeptide / positive regulation of cholesterol storage / long-chain fatty acid import into cell / triglyceride transport / : / response to stilbenoid / production of molecular mediator involved in inflammatory response / Scavenging by Class B Receptors / plasma lipoprotein particle clearance / regulation of action potential / lipid transport across blood-brain barrier / positive regulation of blood microparticle formation / regulation of lipopolysaccharide-mediated signaling pathway / neutrophil degranulation / cholesterol import / cellular response to hydroperoxide / high-density lipoprotein particle binding / low-density lipoprotein particle clearance / low-density lipoprotein particle receptor activity / platelet degranulation / cellular response to oxidised low-density lipoprotein particle stimulus / Cross-presentation of particulate exogenous antigens (phagosomes) / intestinal cholesterol absorption / Toll-like receptor binding / regulation of removal of superoxide radicals / low-density lipoprotein particle binding / platelet alpha granule membrane / positive regulation of macrophage derived foam cell differentiation / amyloid-beta clearance by cellular catabolic process / Regulation of TLR by endogenous ligand / scavenger receptor activity / positive regulation of phagocytosis, engulfment / lipid storage / response to fatty acid / phagocytosis, recognition / regulation of metabolic process / cholesterol transport / transforming growth factor beta binding / MyD88 deficiency (TLR2/4) / apoptotic cell clearance / intestinal absorption / positive regulation of macrophage cytokine production / MyD88-dependent toll-like receptor signaling pathway / positive regulation of reactive oxygen species biosynthetic process / positive regulation of cell-matrix adhesion / IRAK4 deficiency (TLR2/4) / lipoprotein transport / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / long-chain fatty acid transmembrane transporter activity / positive regulation of NLRP3 inflammasome complex assembly / toll-like receptor signaling pathway / negative regulation of protein import into nucleus / phagocytosis, engulfment / response to lipid / regulation of toll-like receptor signaling pathway / cGMP-mediated signaling / thrombospondin receptor activity / plasma membrane => GO:0005886 / lipoprotein particle binding / cellular response to lipoteichoic acid / cellular response to low-density lipoprotein particle stimulus / regulation of protein-containing complex assembly / positive regulation of blood coagulation / nitric oxide mediated signal transduction / long-chain fatty acid transport / specific granule membrane / energy homeostasis / positive regulation of interleukin-12 production / phagocytic vesicle / receptor-mediated endocytosis / fatty acid metabolic process / positive regulation of interleukin-1 beta production / caveola / cell periphery / brush border membrane / receptor internalization / lipid metabolic process / PPARA activates gene expression / cytokine-mediated signaling pathway / Transcriptional regulation of white adipocyte differentiation / sensory perception of taste / cellular response to amyloid-beta / endocytic vesicle membrane / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of nitric oxide biosynthetic process Similarity search - Function CD36 / CD36/scavenger receptor class B member 1 / Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment / N-terminal segments of PfEMP1 / CD36 family / CD36 family / Cysteine-rich interdomain region 1 gamma / Cysteine-Rich Interdomain Region 1 gamma / Duffy-binding-like domain / PFEMP1 DBL domain ... CD36 / CD36/scavenger receptor class B member 1 / Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment / N-terminal segments of PfEMP1 / CD36 family / CD36 family / Cysteine-rich interdomain region 1 gamma / Cysteine-Rich Interdomain Region 1 gamma / Duffy-binding-like domain / PFEMP1 DBL domain / Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment superfamily / Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment / acidic terminal segments, variant surface antigen of PfEMP1 / Duffy-antigen binding / Duffy-antigen binding superfamily / Duffy binding domain Similarity search - Domain/homologyBiological species Homo sapiens (human)Plasmodium falciparum (malaria parasite P. falciparum)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.07 Å DetailsAuthors Hsieh, F.L. / Higgins, M.K. Funding support United Kingdom, 1items Details Hide detailsOrganization Grant number Country Wellcome Trust 101020/Z/13/Z United Kingdom
CitationJournal : Nat Commun / Year : 2016Title : The structural basis for CD36 binding by the malaria parasite.Authors : Hsieh, F.L. / Turner, L. / Bolla, J.R. / Robinson, C.V. / Lavstsen, T. / Higgins, M.K. History Deposition Jul 6, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 31, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Oct 5, 2016 Group : Database referencesRevision 1.2 Oct 16, 2019 Group : Data collection / Category : reflns_shellRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.auth_asym_id / _atom_site.auth_seq_id ... _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _atom_site_anisotrop.pdbx_auth_asym_id / _atom_site_anisotrop.pdbx_auth_seq_id / _atom_site_anisotrop.pdbx_label_asym_id / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Jan 10, 2024 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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