- PDB-5l19: Crystal Structure of a human FasL mutant -
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ID or keywords:
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Basic information
Entry
Database: PDB / ID: 5l19
Title
Crystal Structure of a human FasL mutant
Components
Tumor necrosis factor ligand superfamily member 6
Keywords
APOPTOSIS / FasL / CD95L / TNF ligand
Function / homology
Function and homology information
release of sequestered calcium ion into cytosol by endoplasmic reticulum / positive regulation of phosphatidylserine exposure on apoptotic cell surface / inflammatory cell apoptotic process / cytoplasmic vesicle lumen / FasL/ CD95L signaling / retinal cell programmed cell death / intracellular chloride ion homeostasis / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 ...release of sequestered calcium ion into cytosol by endoplasmic reticulum / positive regulation of phosphatidylserine exposure on apoptotic cell surface / inflammatory cell apoptotic process / cytoplasmic vesicle lumen / FasL/ CD95L signaling / retinal cell programmed cell death / intracellular chloride ion homeostasis / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / Caspase activation via Death Receptors in the presence of ligand / T cell apoptotic process / endosomal lumen acidification / necroptotic signaling pathway / positive regulation of endothelial cell apoptotic process / response to growth factor / tumor necrosis factor receptor binding / death receptor binding / RIPK1-mediated regulated necrosis / positive regulation of epidermal growth factor receptor signaling pathway / FOXO-mediated transcription of cell death genes / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / necroptotic process / extrinsic apoptotic signaling pathway via death domain receptors / extrinsic apoptotic signaling pathway / negative regulation of angiogenesis / lysosomal lumen / cytokine activity / caveola / apoptotic signaling pathway / cellular response to type II interferon / activation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of neuron apoptotic process / cell-cell signaling / Interleukin-4 and Interleukin-13 signaling / positive regulation of canonical NF-kappaB signal transduction / response to lipopolysaccharide / positive regulation of apoptotic process / external side of plasma membrane / signaling receptor binding / apoptotic process / positive regulation of cell population proliferation / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / extracellular exosome / extracellular region / nucleus / plasma membrane Similarity search - Function
Resolution: 2→50 Å / Cor.coef. Fo:Fc: 0.963 / Cor.coef. Fo:Fc free: 0.925 / SU B: 4.424 / SU ML: 0.118 / Cross valid method: THROUGHOUT / ESU R: 0.178 / ESU R Free: 0.16 / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.21602
521
5.2 %
RANDOM
Rwork
0.16512
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obs
0.16775
9414
99.21 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å