Entry Database : PDB / ID : 5kkn Structure visualization Downloads & linksTitle Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630 ComponentsAcetyl-CoA carboxylase 2 Details Keywords LYASE / biotin-dependent carboxylase / grasp foldFunction / homology Function and homology informationFunction Domain/homology Component
intracellular aspartate homeostasis / lactic acid secretion / mitochondrial fatty acid beta-oxidation multienzyme complex / regulation of cardiac muscle hypertrophy in response to stress / positive regulation of heart growth / acetyl-CoA carboxylase / Biotin transport and metabolism / negative regulation of fatty acid beta-oxidation / acetyl-CoA metabolic process / tricarboxylic acid metabolic process ... intracellular aspartate homeostasis / lactic acid secretion / mitochondrial fatty acid beta-oxidation multienzyme complex / regulation of cardiac muscle hypertrophy in response to stress / positive regulation of heart growth / acetyl-CoA carboxylase / Biotin transport and metabolism / negative regulation of fatty acid beta-oxidation / acetyl-CoA metabolic process / tricarboxylic acid metabolic process / malonyl-CoA biosynthetic process / ChREBP activates metabolic gene expression / acetyl-CoA carboxylase activity / intracellular glutamate homeostasis / positive regulation of lipid storage / Carnitine metabolism / pentose-phosphate shunt / biotin binding / glucose import / fatty acid oxidation / regulation of glucose metabolic process / energy homeostasis / response to nutrient / Activation of gene expression by SREBF (SREBP) / response to organic cyclic compound / fatty acid biosynthetic process / protein homotetramerization / mitochondrial outer membrane / response to xenobiotic stimulus / negative regulation of gene expression / mitochondrion / ATP binding / identical protein binding / nucleus / metal ion binding / cytosol Similarity search - Function PreATP-grasp fold / PreATP-grasp domain / Acetyl-CoA carboxylase, central domain / : / : / Acetyl-CoA carboxylase, central region / Acetyl-CoA carboxylase, BT domain / Acetyl-coenzyme A carboxyltransferase, C-terminal / Acetyl-coenzyme A (CoA) carboxyltransferase C-terminal domain profile. / Acetyl-coenzyme A carboxyltransferase, N-terminal ... PreATP-grasp fold / PreATP-grasp domain / Acetyl-CoA carboxylase, central domain / : / : / Acetyl-CoA carboxylase, central region / Acetyl-CoA carboxylase, BT domain / Acetyl-coenzyme A carboxyltransferase, C-terminal / Acetyl-coenzyme A (CoA) carboxyltransferase C-terminal domain profile. / Acetyl-coenzyme A carboxyltransferase, N-terminal / Acetyl-coenzyme A (CoA) carboxyltransferase N-terminal domain profile. / Acetyl-CoA carboxylase / Carboxyl transferase domain / Biotin carboxylase-like, N-terminal domain / Biotin carboxylase, C-terminal / Biotin carboxylation domain / Biotin carboxylase, N-terminal domain / Biotin carboxylase C-terminal domain / Biotin carboxylation domain profile. / Biotin carboxylase C-terminal domain / Rossmann fold - #20 / Carbamoyl-phosphate synthase subdomain signature 1. / Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain / Carbamoyl-phosphate synthase L chain, ATP binding domain / Biotin-requiring enzyme / ATP-grasp fold, A domain / Rudiment single hybrid motif / Biotinyl/lipoyl domain profile. / Biotin/lipoyl attachment / Single hybrid motif / ATP-grasp fold, B domain / ATP-grasp fold, subdomain 1 / Pre-ATP-grasp domain superfamily / ATP-grasp fold / ATP-grasp fold profile. / D-amino Acid Aminotransferase; Chain A, domain 1 / ClpP/crotonase-like domain superfamily / Dna Ligase; domain 1 / Carbamoyl-phosphate synthase subdomain signature 2. / Alpha-Beta Complex / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 2.6 Å DetailsAuthors Wang, R. / Paul, D. / Tong, L. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2016Title : Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.Authors : Harriman, G. / Greenwood, J. / Bhat, S. / Huang, X. / Wang, R. / Paul, D. / Tong, L. / Saha, A.K. / Westlin, W.F. / Kapeller, R. / Harwood, H.J. History Deposition Jun 22, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 13, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Nov 1, 2017 Group : Author supporting evidence / Database references ... Author supporting evidence / Database references / Derived calculations / Refinement description Category : citation / pdbx_struct_assembly_auth_evidence ... citation / pdbx_struct_assembly_auth_evidence / pdbx_struct_oper_list / software Item : _citation.journal_id_CSD / _pdbx_struct_oper_list.symmetry_operation / _software.classificationRevision 1.2 Mar 6, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less