登録情報 データベース : PDB / ID : 5kiz 構造の表示 ダウンロードとリンクタイトル Solution Structure of a repacked version of HIF-2 alpha PAS-B 要素Endothelial PAS domain-containing protein 1 詳細 キーワード TRANSCRIPTION / Cavity / Repacking / Rosetta機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
myoblast fate commitment / Cellular response to hypoxia / regulation of protein neddylation / Transcriptional regulation of pluripotent stem cells / PTK6 Expression / norepinephrine metabolic process / surfactant homeostasis / epithelial cell maturation / Regulation of gene expression by Hypoxia-inducible Factor / embryonic placenta development ... myoblast fate commitment / Cellular response to hypoxia / regulation of protein neddylation / Transcriptional regulation of pluripotent stem cells / PTK6 Expression / norepinephrine metabolic process / surfactant homeostasis / epithelial cell maturation / Regulation of gene expression by Hypoxia-inducible Factor / embryonic placenta development / blood vessel remodeling / visual perception / Pexophagy / regulation of heart rate / mitochondrion organization / erythrocyte differentiation / RNA polymerase II transcription regulatory region sequence-specific DNA binding / lung development / mRNA transcription by RNA polymerase II / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / multicellular organismal-level iron ion homeostasis / transcription coactivator binding / Neddylation / positive regulation of cold-induced thermogenesis / cellular response to hypoxia / DNA-binding transcription activator activity, RNA polymerase II-specific / angiogenesis / RNA polymerase II-specific DNA-binding transcription factor binding / response to oxidative stress / transcription regulator complex / response to hypoxia / DNA-binding transcription factor activity, RNA polymerase II-specific / nuclear speck / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin / regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / cytosol 類似検索 - 分子機能 HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor, alpha subunit-like / Hypoxia-inducible factor-1 / Nuclear translocator / PAS fold / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / PAS domain / PAS domain ... HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor, alpha subunit-like / Hypoxia-inducible factor-1 / Nuclear translocator / PAS fold / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / PAS domain / PAS domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Beta-Lactamase / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 溶液NMR / torsion angle dynamics 詳細データ登録者 Correa, F. / Key, J. / Kuhlman, B. / Gardner, K.H. 資金援助 米国, 2件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Cancer Institute (NIH/NCI) CA95471 米国 Cancer Prevention and Research Institute of Texas (CPRIT) RP130513 米国
引用ジャーナル : Structure / 年 : 2016タイトル : Computational Repacking of HIF-2 alpha Cavity Replaces Water-Based Stabilized Core.著者 : Correa, F. / Key, J. / Kuhlman, B. / Gardner, K.H. 履歴 登録 2016年6月17日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年8月17日 Provider : repository / タイプ : Initial release改定 1.1 2017年9月20日 Group : Author supporting evidence / Structure summary / カテゴリ : entity / pdbx_audit_supportItem : _entity.pdbx_number_of_molecules / _pdbx_audit_support.funding_organization改定 1.2 2019年12月4日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.3 2021年9月22日 Group : Database references / カテゴリ : citation / database_2Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession 改定 1.4 2023年6月14日 Group : Other / カテゴリ : pdbx_database_status / Item : _pdbx_database_status.status_code_nmr_data改定 1.5 2024年5月15日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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