登録情報 | データベース: PDB / ID: 5k9d |
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タイトル | Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution |
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要素 | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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キーワード | OXIDOREDUCTASE / alpha/beta barrel |
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機能・相同性 | 機能・相同性情報
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ...pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / plasma membrane / cytosol類似検索 - 分子機能 Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 ACETATE ION / DODECYL NONA ETHYLENE GLYCOL ETHER / Chem-FNR / OROTIC ACID / Dihydroorotate dehydrogenase (quinone), mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.7 Å |
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データ登録者 | Lewis, T.A. / Sykes, D.B. / Law, J.M. / Munoz, B. / Scadden, D.T. / Rustiguel, J.K. / Nonato, M.C. / Schreiber, S.L. |
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引用 | ジャーナル: ACS Med Chem Lett / 年: 2016 タイトル: Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. 著者: Lewis, T.A. / Sykes, D.B. / Law, J.M. / Munoz, B. / Rustiguel, J.K. / Nonato, M.C. / Scadden, D.T. / Schreiber, S.L. |
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履歴 | 登録 | 2016年5月31日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年10月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年1月4日 | Group: Database references |
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改定 1.2 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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