Entry | Database: PDB / ID: 5k22 |
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Title | Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3 |
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Components | - Metal transporter CNNM3
- Protein tyrosine phosphatase type IVA 2
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Keywords | TRANSPORT PROTEIN/PROTEIN BINDING / alpha-beta fold / complex / protein binding / phosphatase / TRANSPORT PROTEIN-PROTEIN BINDING complex |
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Function / homology | Function and homology information
: / magnesium ion homeostasis / RAB geranylgeranylation / transmembrane transporter activity / monoatomic ion transport / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / early endosome / membrane / nucleus ...: / magnesium ion homeostasis / RAB geranylgeranylation / transmembrane transporter activity / monoatomic ion transport / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / early endosome / membrane / nucleus / plasma membrane / cytosol / cytoplasmSimilarity search - Function Ancient conserved domain protein family / Ion transporter-like, CBS domain / : / CNNM, transmembrane domain / CNNM transmembrane domain profile. / CBS-domain / CBS-domain / Dual specificity protein phosphatase domain / Dual specificity protein phosphatase domain profile. / CBS domain superfamily ...Ancient conserved domain protein family / Ion transporter-like, CBS domain / : / CNNM, transmembrane domain / CNNM transmembrane domain profile. / CBS-domain / CBS-domain / Dual specificity protein phosphatase domain / Dual specificity protein phosphatase domain profile. / CBS domain superfamily / CBS domain / CBS domain / CBS domain profile. / Protein tyrosine phosphatase superfamily / Protein-Tyrosine Phosphatase; Chain A / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / Roll / Alpha-Beta Complex / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 3 Å |
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Authors | Kozlov, G. / Wu, H. / Gehring, K. |
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Citation | Journal: EMBO Rep. / Year: 2016 Title: Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis. Authors: Gulerez, I. / Funato, Y. / Wu, H. / Yang, M. / Kozlov, G. / Miki, H. / Gehring, K. |
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History | Deposition | May 18, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Oct 12, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 3, 2018 | Group: Data collection / Database references / Derived calculations Category: citation / citation_author / pdbx_struct_oper_list Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _pdbx_struct_oper_list.symmetry_operation |
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Revision 1.2 | Mar 6, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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