Domain 4 Segment 6 of voltage-gated sodium channel Nav1.4
Components
Sodium channel protein type 4 subunit alpha
Keywords
METAL BINDING PROTEIN / transmembrane / alpha-helix / protein fragment
Function / homology
Function and homology information
regulation of skeletal muscle contraction by action potential / choline transport / voltage-gated monoatomic ion channel activity / membrane depolarization during action potential / voltage-gated sodium channel complex / regulation of monoatomic ion transmembrane transport / voltage-gated sodium channel activity / sodium ion transport / monoatomic cation transport / neuronal action potential ...regulation of skeletal muscle contraction by action potential / choline transport / voltage-gated monoatomic ion channel activity / membrane depolarization during action potential / voltage-gated sodium channel complex / regulation of monoatomic ion transmembrane transport / voltage-gated sodium channel activity / sodium ion transport / monoatomic cation transport / neuronal action potential / sodium ion transmembrane transport / potassium ion transport / axon / plasma membrane Similarity search - Function
Voltage gated sodium channel, alpha-4 subunit, mammalian / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / IQ motif, EF-hand binding site / IQ motif profile. / Voltage-dependent channel domain superfamily / Ion transport domain / Ion transport protein Similarity search - Domain/homology
16 % U-13C G, I, F, L, V, A peptide, 69 % d-54 DMPC, water
Label2
water
Sample
Conc. (mg/ml)
Component
Isotopic labeling
Solution-ID
16 %
peptide
U-13C I23, L17, V20
1
69 %
DMPC
d-54
1
16 %
peptide
U-13C G, I, F, L, V, A
2
69 %
DMPC
d-54
2
Sample conditions
Ionic strength: 0 Not defined / Label: condition_1 / pH: 7.4 Not defined / Pressure: 1 atm / Temperature: 213 K
-
NMR measurement
NMR spectrometer
Type: Varian Infinity Plus 700 / Manufacturer: Varian / Model: Infinity Plus 700 / Field strength: 700 MHz
-
Processing
NMR software
Name
Developer
Classification
CHARMM
M. KARPLUSETAL, HARVARDUNIVERSITY
refinement
FELIX
structuresolution
DELTA
structuresolution
SPARKY
structuresolution
Refinement
Method: molecular dynamics / Software ordinal: 1
NMR ensemble
Conformer selection criteria: structures with the least restraint violations Conformers calculated total number: 1000 / Conformers submitted total number: 10
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