Entry Database : PDB / ID : 5j5e Structure visualization Downloads & linksTitle crystal structure of antigen-ERAP1 domain complex ComponentsEndoplasmic reticulum aminopeptidase 1 Details Keywords HYDROLASE / AMINOPEPTIDASEFunction / homology Function and homology informationFunction Domain/homology Component
interleukin-1, type II receptor binding / interleukin-6 receptor binding / Hydrolases; Acting on peptide bonds (peptidases); Aminopeptidases / antigen processing and presentation of peptide antigen via MHC class I / metalloexopeptidase activity / peptide catabolic process / regulation of innate immune response / fat cell differentiation / metalloaminopeptidase activity / membrane protein ectodomain proteolysis ... interleukin-1, type II receptor binding / interleukin-6 receptor binding / Hydrolases; Acting on peptide bonds (peptidases); Aminopeptidases / antigen processing and presentation of peptide antigen via MHC class I / metalloexopeptidase activity / peptide catabolic process / regulation of innate immune response / fat cell differentiation / metalloaminopeptidase activity / membrane protein ectodomain proteolysis / aminopeptidase activity / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / peptide binding / response to bacterium / antigen processing and presentation of endogenous peptide antigen via MHC class I / regulation of blood pressure / positive regulation of angiogenesis / angiogenesis / endopeptidase activity / adaptive immune response / endoplasmic reticulum lumen / endoplasmic reticulum membrane / endoplasmic reticulum / proteolysis / extracellular space / zinc ion binding / extracellular exosome / extracellular region / membrane / cytoplasm / cytosol Similarity search - Function Zincin-like fold - #20 / Immunoglobulin-like - #1910 / Aminopeptidase N-type / ERAP1-like C-terminal domain / ERAP1-like C-terminal domain / Zincin-like fold / Aminopeptidase N-like , N-terminal domain / Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase / Peptidase M1, membrane alanine aminopeptidase / Peptidase family M1 domain ... Zincin-like fold - #20 / Immunoglobulin-like - #1910 / Aminopeptidase N-type / ERAP1-like C-terminal domain / ERAP1-like C-terminal domain / Zincin-like fold / Aminopeptidase N-like , N-terminal domain / Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase / Peptidase M1, membrane alanine aminopeptidase / Peptidase family M1 domain / Peptidase M1 N-terminal domain / Aminopeptidase N-like , N-terminal domain superfamliy / Peptidase M4/M1, CTD superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. / Alpha Horseshoe / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Sui, L. / Gandhi, A. / Guo, H.-C. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI068831 United States National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI078134 United States
Citation Show more 1 items Show lessHistory Deposition Apr 2, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 12, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2017 Group : Advisory / Author supporting evidence / Refinement descriptionCategory : pdbx_audit_support / pdbx_database_PDB_obs_spr / softwareItem : _pdbx_audit_support.funding_organization / _software.classificationRevision 1.2 Dec 11, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.3 May 19, 2021 Group : Database references / Category : citation / citation_authorRevision 1.4 Apr 27, 2022 Group : Advisory / Database references / Category : database_2 / pdbx_database_PDB_obs_sprItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 1.5 Sep 27, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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