登録情報 | データベース: PDB / ID: 5isa |
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タイトル | Crystal structure of mouse CARM1 in complex with inhibitor SA0401 |
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要素 | Histone-arginine methyltransferase CARM1 |
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キーワード | TRANSFERASE / PROTEIN ARGININE METHYLTRANSFERASE / CATALYTIC DOMAIN / CHROMATIN REGULATOR / MRNA PROCESSING / MRNA SPLICING / NUCLEUS / S-ADENOSYL-L-METHIONINE / TRANSCRIPTION / TRANSCRIPTION REGULATION |
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機能・相同性 | 機能・相同性情報
histone H3R26 methyltransferase activity / regulation of growth plate cartilage chondrocyte proliferation / histone H3R17 methyltransferase activity / endochondral bone morphogenesis / histone H3R2 methyltransferase activity / RMTs methylate histone arginines / type I protein arginine methyltransferase / negative regulation of dendrite development / Regulation of lipid metabolism by PPARalpha / protein-arginine omega-N asymmetric methyltransferase activity ...histone H3R26 methyltransferase activity / regulation of growth plate cartilage chondrocyte proliferation / histone H3R17 methyltransferase activity / endochondral bone morphogenesis / histone H3R2 methyltransferase activity / RMTs methylate histone arginines / type I protein arginine methyltransferase / negative regulation of dendrite development / Regulation of lipid metabolism by PPARalpha / protein-arginine omega-N asymmetric methyltransferase activity / Cytoprotection by HMOX1 / protein methyltransferase activity / Estrogen-dependent gene expression / regulation of intracellular estrogen receptor signaling pathway / replication fork reversal / protein-arginine N-methyltransferase activity / positive regulation of fat cell differentiation / histone methyltransferase activity / nuclear replication fork / estrogen receptor signaling pathway / nuclear receptor-mediated steroid hormone signaling pathway / protein localization to chromatin / lysine-acetylated histone binding / response to cAMP / nuclear receptor coactivator activity / RNA polymerase II transcription regulator complex / methylation / transcription coactivator activity / transcription cis-regulatory region binding / cell population proliferation / chromatin remodeling / positive regulation of cell population proliferation / regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / protein-containing complex / nucleus / cytosol類似検索 - 分子機能 Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / PH-like domain superfamily ...Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / PH-like domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 Chem-6D5 / 1,2-DIMETHOXYETHANE / 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE / DI(HYDROXYETHYL)ETHER / Histone-arginine methyltransferase CARM1類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Cura, V. / Marechal, N. / Mailliot, J. / Troffer-Charlier, N. / Hassenboehler, P. / Wurtz, J.M. / Bonnefond, L. / Cavarelli, J. |
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引用 | ジャーナル: To Be Published タイトル: Crystal structure of mouse CARM1 in complex with inhibitor SA0401 著者: Cura, V. / Marechal, N. / Mailliot, J. / Troffer-Charlier, N. / Wurtz, J.M. / Bonnefond, L. / Cavarelli, J. |
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履歴 | 登録 | 2016年3月15日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2017年3月15日 | Provider: repository / タイプ: Initial release |
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改定 2.0 | 2018年3月7日 | Group: Atomic model / Non-polymer description / Structure summary カテゴリ: atom_site / entity Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_atom_id / _atom_site.label_atom_id / _chem_comp.formula / _chem_comp.name / _entity.formula_weight / _entity.pdbx_description |
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改定 2.1 | 2024年1月10日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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