Entry | Database: PDB / ID: 5ipf |
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Title | Crystal structure of Hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni in complex with IMP |
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Components | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
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Keywords | TRANSFERASE / Hypoxanthine-guanine phosphoribosyltransferase / enzyme |
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Function / homology | Function and homology information
hypoxanthine phosphoribosyltransferase / guanine phosphoribosyltransferase activity / hypoxanthine phosphoribosyltransferase activity / IMP salvage / purine ribonucleoside salvage / nucleotide binding / metal ion binding / cytoplasmSimilarity search - Function Hypoxanthine phosphoribosyl transferase / Purine/pyrimidine phosphoribosyl transferases signature. / Rossmann fold - #2020 / Phosphoribosyl transferase domain / Phosphoribosyltransferase-like / Phosphoribosyltransferase domain / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_invertebrata.gif) Schistosoma mansoni (invertebrata) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.8 Å |
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Authors | Romanello, L. / Torini, J.R.S. / Bird, L.E. / Nettleship, J.E. / Owens, R.J. / DeMarco, R. / Pereira, H.M. / Brandao-Neto, J. |
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Funding support | Brazil, 2items Organization | Grant number | Country |
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Sao Paulo Research Foundation (FAPESP) | 2012/14223-9 | Brazil | Brazilian National Council for Scientific and Technological Development (CNPq) | 474402/2013-4 | Brazil |
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Citation | Journal: Mol. Biochem. Parasitol. / Year: 2019 Title: In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases. Authors: Romanello, L. / Zeraik, A.E. / de Freitas Fernandes, A. / Torini, J.R. / Bird, L.E. / Nettleship, J.E. / Rada, H. / Reddivari, Y. / Owens, R.J. / Serrao, V.H.B. / DeMarco, R. / Brandao-Neto, J. / Pereira, H.D. |
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History | Deposition | Mar 9, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Mar 15, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 27, 2019 | Group: Data collection / Database references / Category: citation / citation_author / diffrn_source Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _diffrn_source.pdbx_synchrotron_site |
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Revision 2.0 | Apr 17, 2019 | Group: Author supporting evidence / Data collection / Polymer sequence Category: entity_poly / pdbx_audit_support Item: _entity_poly.pdbx_target_identifier / _pdbx_audit_support.funding_organization |
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Revision 2.1 | Jan 1, 2020 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 2.2 | Sep 27, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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