Entry | Database: PDB / ID: 5hv9 |
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Title | Human LTC4S mutant-S36E |
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Components | Leukotriene C4 synthase |
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Keywords | LYASE / LTC4S / mutant |
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Function / homology | Function and homology information
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) / Biosynthesis of maresin conjugates in tissue regeneration (MCTR) / leukotriene-C4 synthase / leukotriene-C4 synthase activity / Synthesis of Lipoxins (LX) / Synthesis of 5-eicosatetraenoic acids / leukotriene metabolic process / Transferases; Transferring alkyl or aryl groups, other than methyl groups / Synthesis of Leukotrienes (LT) and Eoxins (EX) / leukotriene biosynthetic process ...Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) / Biosynthesis of maresin conjugates in tissue regeneration (MCTR) / leukotriene-C4 synthase / leukotriene-C4 synthase activity / Synthesis of Lipoxins (LX) / Synthesis of 5-eicosatetraenoic acids / leukotriene metabolic process / Transferases; Transferring alkyl or aryl groups, other than methyl groups / Synthesis of Leukotrienes (LT) and Eoxins (EX) / leukotriene biosynthetic process / glutathione peroxidase activity / nuclear outer membrane / long-chain fatty acid biosynthetic process / glutathione transferase activity / enzyme activator activity / nuclear envelope / nuclear membrane / intracellular membrane-bounded organelle / lipid binding / endoplasmic reticulum membrane / endoplasmic reticulum / identical protein binding / membraneSimilarity search - Function 5-lipoxygenase-activating protein / FLAP/GST2/LTC4S, conserved site / FLAP/GST2/LTC4S family signature. / Membrane associated eicosanoid/glutathione metabolism-like domain / Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein / Membrane associated eicosanoid/glutathione metabolism-like domain superfamily / MAPEG family / Four Helix Bundle (Hemerythrin (Met), subunit A) / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3 Å |
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Authors | Thulasingam, M. / Ahmad, H.R.S. / Rinaldo-Matthis, A. / Haeggstrom, J.Z. |
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Funding support | Sweden, 1items Organization | Grant number | Country |
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Swedish Research Council | | Sweden |
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Citation | Journal: J.Biol.Chem. / Year: 2016 Title: Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity. Authors: Ahmad, S. / Ytterberg, A.J. / Thulasingam, M. / Tholander, F. / Bergman, T. / Zubarev, R. / Wetterholm, A. / Rinaldo-Matthis, A. / Haeggstrom, J.Z. |
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History | Deposition | Jan 28, 2016 | Deposition site: RCSB / Processing site: PDBE |
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Revision 1.0 | Jul 13, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 20, 2016 | Group: Database references |
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Revision 1.2 | Sep 7, 2016 | Group: Database references |
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Revision 1.3 | Sep 13, 2017 | Group: Advisory / Author supporting evidence / Category: pdbx_audit_support / pdbx_unobs_or_zero_occ_atoms / Item: _pdbx_audit_support.funding_organization |
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Revision 1.4 | Jan 10, 2024 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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