+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 5hpd | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
タイトル | Solution Structure of TAZ2-p53TAD | |||||||||
要素 | CREB-binding protein,Cellular tumor antigen p53 fusion protein | |||||||||
キーワード | TRANSCRIPTION (転写 (生物学)) / intrinsically disordered protein (天然変性タンパク質) / binding motif / transcriptional coactivator / protein-protein interaction (タンパク質間相互作用) / tumor suppressor (がん抑制遺伝子) / TRANSFERASE (転移酵素) | |||||||||
機能・相同性 | 機能・相同性情報 Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / Attenuation phase / Regulation of gene expression by Hypoxia-inducible Factor / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / cAMP response element binding protein binding / Formation of the beta-catenin:TCF transactivating complex ...Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / Attenuation phase / Regulation of gene expression by Hypoxia-inducible Factor / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / cAMP response element binding protein binding / Formation of the beta-catenin:TCF transactivating complex / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / Notch-HLH transcription pathway / positive regulation of cell adhesion molecule production / germ-line stem cell population maintenance / negative regulation of viral process / Regulation of lipid metabolism by PPARalpha / Cytoprotection by HMOX1 / CD209 (DC-SIGN) signaling / Estrogen-dependent gene expression / outer kinetochore / negative regulation of interferon-beta production / histone H3K18 acetyltransferase activity / N-terminal peptidyl-lysine acetylation / histone H3K27 acetyltransferase activity / MRF binding / Loss of function of TP53 in cancer due to loss of tetramerization ability / Regulation of TP53 Expression / signal transduction by p53 class mediator / negative regulation of G1 to G0 transition / negative regulation of glucose catabolic process to lactate via pyruvate / Transcriptional activation of cell cycle inhibitor p21 / regulation of intrinsic apoptotic signaling pathway by p53 class mediator / Activation of NOXA and translocation to mitochondria / negative regulation of pentose-phosphate shunt / peroxisome proliferator activated receptor binding / ATP-dependent DNA/DNA annealing activity / negative regulation of helicase activity / regulation of cell cycle G2/M phase transition / intrinsic apoptotic signaling pathway in response to hypoxia / regulation of fibroblast apoptotic process / oxidative stress-induced premature senescence / oligodendrocyte apoptotic process / negative regulation of miRNA processing / positive regulation of thymocyte apoptotic process / glucose catabolic process to lactate via pyruvate / regulation of tissue remodeling / positive regulation of mitochondrial membrane permeability / negative regulation of mitophagy / positive regulation of programmed necrotic cell death / 転写 (生物学) / bone marrow development / circadian behavior / face morphogenesis / histone deacetylase regulator activity / regulation of mitochondrial membrane permeability involved in apoptotic process / RUNX3 regulates CDKN1A transcription / germ cell nucleus / regulation of DNA damage response, signal transduction by p53 class mediator / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / TP53 Regulates Transcription of Death Receptors and Ligands / negative regulation of transcription by RNA polymerase I / Activation of PUMA and translocation to mitochondria / DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / negative regulation of glial cell proliferation / Formation of Senescence-Associated Heterochromatin Foci (SAHF) / negative regulation of neuroblast proliferation / Regulation of TP53 Activity through Association with Co-factors / peptide-lysine-N-acetyltransferase activity / cellular response to hepatocyte growth factor stimulus / mitochondrial DNA repair / T cell lineage commitment / positive regulation of execution phase of apoptosis / positive regulation of dendritic spine development / negative regulation of DNA replication / ER overload response / B cell lineage commitment / thymocyte apoptotic process / TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain / positive regulation of cardiac muscle cell apoptotic process / TP53 Regulates Transcription of Caspase Activators and Caspases / T cell proliferation involved in immune response / cardiac septum morphogenesis / positive regulation of transforming growth factor beta receptor signaling pathway / entrainment of circadian clock by photoperiod / SMAD binding / PI5P Regulates TP53 Acetylation / Association of TriC/CCT with target proteins during biosynthesis / non-canonical NF-kappaB signal transduction / Zygotic genome activation (ZGA) / behavioral response to cocaine / necroptotic process / acetyltransferase activity / rRNA transcription / positive regulation of release of cytochrome c from mitochondria / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / TFIID-class transcription factor complex binding / マイトファジー / cellular response to nutrient levels / SUMOylation of transcription factors 類似検索 - 分子機能 | |||||||||
生物種 | Mus musculus (ハツカネズミ) Homo sapiens (ヒト) | |||||||||
手法 | 溶液NMR / simulated annealing, molecular dynamics | |||||||||
データ登録者 | Krois, A.S. / Ferreon, J.C. / Martinez-Yamout, M.A. / Dyson, H.J. / Wright, P.E. | |||||||||
資金援助 | 米国, 1件
| |||||||||
引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2016 タイトル: Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. 著者: Krois, A.S. / Ferreon, J.C. / Martinez-Yamout, M.A. / Dyson, H.J. / Wright, P.E. | |||||||||
履歴 |
|
-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
---|
-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 5hpd.cif.gz | 946.6 KB | 表示 | PDBx/mmCIF形式 |
---|---|---|---|---|
PDB形式 | pdb5hpd.ent.gz | 801.8 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 5hpd.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/hp/5hpd ftp://data.pdbj.org/pub/pdb/validation_reports/hp/5hpd | HTTPS FTP |
---|
-関連構造データ
-リンク
-集合体
登録構造単位 |
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
NMR アンサンブル |
|
-要素
#1: タンパク質 | 分子量: 17711.236 Da / 分子数: 1 / 断片: p53TAD, TAZ2 domain of CBP / 由来タイプ: 組換発現 由来: (組換発現) Mus musculus (ハツカネズミ), (組換発現) Homo sapiens (ヒト) 遺伝子: Crebbp, Cbp, TP53, P53 / 発現宿主: Escherichia coli (大腸菌) / 株 (発現宿主): BL21 (DE3) [DNAY] 参照: UniProt: P45481, UniProt: P04637, ヒストンアセチルトランスフェラーゼ |
---|---|
#2: 化合物 |
-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NMR実験 |
|
-試料調製
詳細 |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
試料 |
|