PDB-5hj3: Crystal structure of host-primed Ebola virus GP, GPcl.

ID or keywords:

Entry

Database: PDB / ID: 5hj3

Title

Crystal structure of host-primed Ebola virus GP, GPcl.

Components

(Envelope glycoprotein) x 2
(KZ52 Antibody Fragment) x 2

Keywords

VIRAL PROTEIN/IMMUNE SYSTEM / Ebola virus / EOV / Ebolavirus / GP / glycoprotein / GPcl / cleaved / primed / proteolytically / receptor binding pocket / crest / trough / MR72 / KZ52 / broadly neutralizing / VIRAL PROTEIN-IMMUNE SYSTEM complex

Function / homology

Function and homology information

host cell endoplasmic reticulum / viral budding from plasma membrane / clathrin-dependent endocytosis of virus by host cell / symbiont-mediated-mediated suppression of host tetherin activity / entry receptor-mediated virion attachment to host cell / host cell cytoplasm / symbiont-mediated suppression of host innate immune response / membrane raft / symbiont entry into host cell / fusion of virus membrane with host endosome membrane ...
Similarity search - Function

Biological species

Ebola virus sp.

Zaire ebolavirus

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 3.3 Å

Authors

Bornholdt, Z.A. / Fusco, M.L. / Saphire, E.O.

Citation

Journal: Mbio / Year: 2016
Title: Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
Authors: Bornholdt, Z.A. / Ndungo, E. / Fusco, M.L. / Bale, S. / Flyak, A.I. / Crowe, J.E. / Chandran, K. / Saphire, E.O.

History

Deposition	Jan 12, 2016	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Mar 9, 2016	Provider: repository / Type: Initial release
Revision 1.1	May 4, 2016	Group: Database references
Revision 2.0	Jul 29, 2020	Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary Category: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_oper_list / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description: Carbohydrate remediation / Provider: repository / Type: Remediation
Revision 2.1	Oct 30, 2024	Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / struct_conn Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	5hj3.cif.gz	1.5 MB	Display	PDBx/mmCIF format
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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/hj/5hj3 ftp://data.pdbj.org/pub/pdb/validation_reports/hj/5hj3	HTTPS FTP

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Related structure data

Similar structure data	6oz9-1 7956 3csy-2 7955 3csy-1 7928 Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#178 - Oct 2014 Ebola Virus Proteins similarity (6) #21 - Sep 2001 Antibodies similarity (1) #256 - Apr 2021 SARS-CoV-2 Spike and Antibodies similarity (1) #241 - Jan 2020 Twenty Years of Molecules similarity (4)

Deposited unit

C: Envelope glycoprotein

D: Envelope glycoprotein

E: KZ52 Antibody Fragment

F: KZ52 Antibody Fragment

G: Envelope glycoprotein

H: Envelope glycoprotein

I: KZ52 Antibody Fragment

J: KZ52 Antibody Fragment

K: Envelope glycoprotein

L: Envelope glycoprotein

M: KZ52 Antibody Fragment

N: KZ52 Antibody Fragment

O: Envelope glycoprotein

P: Envelope glycoprotein

A: KZ52 Antibody Fragment

B: KZ52 Antibody Fragment

hetero molecules

336 kDa, 16 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

C: Envelope glycoprotein

D: Envelope glycoprotein

I: KZ52 Antibody Fragment

J: KZ52 Antibody Fragment

hetero molecules

C: Envelope glycoprotein

D: Envelope glycoprotein

I: KZ52 Antibody Fragment

J: KZ52 Antibody Fragment

hetero molecules

C: Envelope glycoprotein

D: Envelope glycoprotein

I: KZ52 Antibody Fragment

J: KZ52 Antibody Fragment

hetero molecules

defined by author
252 kDa, 12 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

E: KZ52 Antibody Fragment

F: KZ52 Antibody Fragment

G: Envelope glycoprotein

H: Envelope glycoprotein

K: Envelope glycoprotein

L: Envelope glycoprotein

M: KZ52 Antibody Fragment

N: KZ52 Antibody Fragment

O: Envelope glycoprotein

P: Envelope glycoprotein

A: KZ52 Antibody Fragment

B: KZ52 Antibody Fragment

hetero molecules

defined by author
252 kDa, 12 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	193.103, 193.103, 350.320
Angle α, β, γ (deg.)	90.000, 90.000, 120.000
Int Tables number	146
Space group name H-M	H3

Noncrystallographic symmetry (NCS)

NCS domain:
NCS domain segments:

Dom-ID	Component-ID	Ens-ID	Selection details	Auth asym-ID
1	1	1	chain A and segid E000	A
2	1	1	chain E and segid	E
3	1	1	chain I and segid	I
4	1	1	chain M and segid	M
1	1	2	chain B and segid E000	B
2	1	2	chain F and segid	F
3	1	2	chain J and segid	J
4	1	2	chain N and segid	N
1	1	3	chain C and segid	C
2	1	3	chain G and segid	G
3	1	3	chain K and segid	K
4	1	3	chain O and segid	O
1	1	4	chain D and segid	D
2	1	4	chain H and segid	H
3	1	4	chain L and segid	L
4	1	4	chain P and segid	P

NCS ensembles :

ID
1
2
3
4

#1: Protein

Envelope glycoprotein / GP1 / 2 / GP

Mass: 19604.180 Da / Num. of mol.: 4 / Fragment: UNP residues 32-194
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Ebola virus sp. / Gene: GP / Production host:

Drosophila (fruit flies) / References: UniProt: Q05320

#2: Protein

Envelope glycoprotein / GP1 / 2 / GP

Mass: 15335.362 Da / Num. of mol.: 4 / Fragment: UNP residues 502-637
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Zaire ebolavirus / Strain: Kikwit-95 / Gene: GP / Production host:

Drosophila (fruit flies) / References: UniProt: P87666

#3: Antibody

KZ52 Antibody Fragment

Mass: 24020.977 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Production host:

Drosophila (fruit flies)

#4: Antibody

KZ52 Antibody Fragment

Mass: 23896.557 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Production host:

Drosophila (fruit flies)

#5: Polysaccharide

alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D- ...

Type: oligosaccharide / Mass: 1235.105 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source

Descriptor	Type	Program
DManpa1-2DManpa1-3[DManpa1-6DManpa1-6]DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-	Glycam Condensed Sequence	GMML 1.0
WURCS=2.0/3,7,6/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3-3/a4-b1_b4-c1_c3-d1_c6-f1_d2-e1_f6-g1	WURCS	PDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{[(2+1)][a-D-Manp]{}}[(6+1)][a-D-Manp]{[(6+1)][a-D-Manp]{}}}}}}	LINUCS	PDB-CARE

Has protein modification

Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 3.79 Å³/Da / Density % sol: 67.55 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 4.7 Details: 25% PEG 550 MME, 10% 2-propanol, 5% ethylene glycol, 100 mM sodium acetate pH 4.7, and 100 mM calcium chloride.

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Data collection

Diffraction

Mean temperature: 80 K

Diffraction source

Source:

SYNCHROTRON / Site:

APS

/ Beamline: 23-ID-D / Wavelength: 1.03316 Å

Detector

Type: PSI PILATUS 6M / Detector: PIXEL / Date: Jun 23, 2013

Radiation

Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray

Radiation wavelength

Wavelength: 1.03316 Å / Relative weight: 1

Reflection

Resolution: 3.3→48.28 Å / Num. obs: 73208 / % possible obs: 99.9 % / Redundancy: 3.89 % / B_iso Wilson estimate: 124.67 Å² / R_merge(I) obs: 0.1 / Χ²: 1.17 / Net I/σ(I): 7 / Num. measured all: 286816 / Scaling rejects: 2152

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	R_merge(I) obs	Mean I/σ(I) obs	Num. measured all	Num. unique all	Χ²	Rejects	% possible all
3.3-3.42	3.88	0.731	1.3	28668	7325	1.51	274	100
3.42-3.55	3.88	0.609	1.7	28564	7292	1.45	272	100
3.55-3.72	3.88	0.484	2.3	28719	7330	1.39	267	100
3.72-3.91	3.89	0.377	3	28826	7359	1.32	222	100
3.91-4.16	3.89	0.268	4.1	28554	7288	1.24	193	100
4.16-4.48	3.9	0.169	6.2	28860	7353	1.09	211	100
4.48-4.93	3.9	0.121	8.7	28700	7307	0.99	178	100
4.93-5.64	3.91	0.105	10	28768	7320	0.97	181	100
5.64-7.1	3.91	0.095	11	28854	7339	0.93	168	100
7.1-48.28	3.85	0.045	21.9	28303	7295	0.84	186	99.5

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Processing

Software

Name	Version	Classification
PHENIX	1.9_1692	refinement
d*TREK	9.9.9.6L	data scaling
PHASER	2.5.4	phasing
PDB_EXTRACT	3.15	data extraction
d*TREK		data reduction

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT / Resolution: 3.3→48.276 Å / SU ML: 0.48 / Cross valid method: FREE R-VALUE / σ(F): 1.96 / Phase error: 29.25 / Stereochemistry target values: ML

	R_factor	Num. reflection	% reflection
R_free	0.2584	3688	5.04 %
R_work	0.2269	69455	-
obs	0.2284	73143	99.86 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso max: 374.24 Å² / B_iso mean: 144.6901 Å² / B_iso min: 20 Å²

Refinement step

Cycle: final / Resolution: 3.3→48.276 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	20544	0	612	0	21156
B_iso mean	-	-	218.01	-	-
Num. residues	-	-	-	-	2680

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.003	21390
X-RAY DIFFRACTION	f_angle_d	0.699	29044
X-RAY DIFFRACTION	f_chiral_restr	0.026	3320
X-RAY DIFFRACTION	f_plane_restr	0.003	3680
X-RAY DIFFRACTION	f_dihedral_angle_d	11.723	7774

Refine LS restraints NCS

Ens-ID	Dom-ID	Auth asym-ID	Number	Refine-ID	Rms	Type
1	1	A	4531	X-RAY DIFFRACTION	6.665	TORSIONAL
1	2	E	4531	X-RAY DIFFRACTION	6.665	TORSIONAL
1	3	I	4531	X-RAY DIFFRACTION	6.665	TORSIONAL
1	4	M	4531	X-RAY DIFFRACTION	6.665	TORSIONAL
2	1	B	4637	X-RAY DIFFRACTION	6.665	TORSIONAL
2	2	F	4637	X-RAY DIFFRACTION	6.665	TORSIONAL
2	3	J	4637	X-RAY DIFFRACTION	6.665	TORSIONAL
2	4	N	4637	X-RAY DIFFRACTION	6.665	TORSIONAL
3	1	C	3720	X-RAY DIFFRACTION	6.665	TORSIONAL
3	2	G	3720	X-RAY DIFFRACTION	6.665	TORSIONAL
3	3	K	3720	X-RAY DIFFRACTION	6.665	TORSIONAL
3	4	O	3720	X-RAY DIFFRACTION	6.665	TORSIONAL
4	1	D	2635	X-RAY DIFFRACTION	6.665	TORSIONAL
4	2	H	2635	X-RAY DIFFRACTION	6.665	TORSIONAL
4	3	L	2635	X-RAY DIFFRACTION	6.665	TORSIONAL
4	4	P	2635	X-RAY DIFFRACTION	6.665	TORSIONAL

LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Total num. of bins used: 26

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Num. reflection all	% reflection obs (%)
3.3-3.3434	0.3723	134	0.3803	2673	2807	100
3.3434-3.3892	0.4427	126	0.3785	2706	2832	100
3.3892-3.4376	0.3726	147	0.3605	2661	2808	100
3.4376-3.4889	0.3123	144	0.3514	2657	2801	100
3.4889-3.5434	0.3749	168	0.334	2657	2825	100
3.5434-3.6015	0.3214	154	0.3219	2671	2825	100
3.6015-3.6636	0.3563	151	0.3194	2640	2791	100
3.6636-3.7302	0.3395	145	0.3068	2674	2819	100
3.7302-3.8019	0.3361	155	0.3101	2669	2824	100
3.8019-3.8795	0.2804	139	0.2938	2656	2795	100
3.8795-3.9638	0.329	161	0.2905	2665	2826	100
3.9638-4.0559	0.2805	152	0.2771	2667	2819	100
4.0559-4.1573	0.2723	138	0.2545	2661	2799	100
4.1573-4.2697	0.2704	132	0.2323	2712	2844	100
4.2697-4.3952	0.2605	114	0.2325	2685	2799	100
4.3952-4.537	0.2347	139	0.2008	2673	2812	100
4.537-4.699	0.2132	143	0.2012	2692	2835	100
4.699-4.887	0.2564	139	0.2028	2680	2819	100
4.887-5.1092	0.2397	132	0.1938	2686	2818	100
5.1092-5.3782	0.2521	129	0.2054	2703	2832	100
5.3782-5.7147	0.2786	139	0.2165	2648	2787	100
5.7147-6.1551	0.2575	140	0.2168	2692	2832	100
6.1551-6.773	0.2328	140	0.2156	2667	2807	100
6.773-7.7496	0.2133	136	0.2088	2685	2821	100
7.7496-9.7504	0.2276	151	0.1694	2659	2810	100
9.7504-48.2809	0.2093	140	0.1845	2616	2756	97

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	9.1914	4.6644	-4.474	4.8913	-2.8487	5.3915	-0.3844	0.4598	-1.142	2.1376	-0.0803	-0.278	-1.0759	-0.7004	0.4762	1.2574	-0.0555	-0.062	1.2559	-0.2145	1.1249	179.9291	96.2966	-0.4796
2	6.3542	-2.574	1.7684	7.314	3.2016	3.633	-0.2469	-1.6849	-1.4498	1.6412	0.2092	0.9803	-0.4617	-0.431	0.044	1.4251	-0.0797	0.2148	1.5818	0.2128	1.5174	183.448	102.0185	5.942
3	3.0335	0.8423	0.0767	4.4356	0.3973	4.0116	0.101	0.5369	-0.3408	-0.7552	0.1103	0.308	0.3875	-0.0521	-0.195	1.1006	-0.0048	0.0283	1.1948	-0.0833	1.0772	179.6222	94.8649	-26.0676
4	5.6738	-3.5606	0.2973	2.8462	2.3974	8.5564	0.0222	0.8721	-0.9569	-0.5932	0.1367	-0.2819	0.8918	-0.3407	-0.2946	1.2223	0.0143	-0.0596	1.3429	-0.1834	1.1041	186.0185	90.4154	-30.3706
5	5.5594	5.3905	0.2698	9.2746	1.2353	0.475	-0.2263	1.3665	0.8396	-0.9788	1.1085	1.7919	0.297	-0.4394	-0.6786	1.2738	0.0781	-0.1941	1.4176	0.0443	1.2054	172.5685	101.1998	-30.8956
6	5.5314	1.8441	-0.154	9.5368	2.4116	8.0366	0.5139	0.6969	-0.8995	-0.8791	0.0291	-0.6134	0.0629	-0.3683	-0.3401	1.232	-0.08	-0.0812	1.1064	-0.012	0.9549	183.9092	97.5599	-26.873
7	7.98	5.4013	4.1207	5.9668	5.0752	4.9598	0.9102	-0.7828	-0.99	0.3928	0.277	-1.1589	0.1201	-0.895	-1.186	1.1484	-0.1395	-0.0922	1.0076	0.0981	1.0539	184.7957	94.778	-8.3173
8	8.3818	0.0976	-2.3473	2.7493	-0.8835	7.4102	0.4351	0.321	-1.0425	-0.4398	-0.2578	-0.0308	0.2406	-0.2312	-0.1896	1.0957	-0.0471	-0.0345	1.12	-0.0701	1.0381	179.3193	85.2771	-11.6732
9	5.7321	-2.8202	-5.723	3.0689	2.7053	5.8866	-2.5033	-0.254	-1.0708	4.7793	1.935	-1.3947	4.1829	0.4101	-0.3947	2.7808	-0.1985	0.0477	1.6667	-0.1391	1.7379	200.1283	90.6472	-11.3075
10	2.4256	1.6307	1.5159	6.0987	4.8033	4.2502	-0.1521	-6.6578	-6.5524	0.3091	-1.3129	0.0006	0.2843	2.609	1.1689	0.9688	0.1866	0.2041	2.1111	0.4467	1.8832	211.8759	88.9896	-14.7986
11	4.5176	0.1278	-2.5074	2.598	-0.3973	1.3662	0.1969	0.1122	-0.4609	-0.1988	-0.0939	0.1737	-0.0612	0.1832	-0.1205	1.1427	0.0453	-0.1984	1.198	-0.1772	0.914	187.3253	95.5974	-14.9364
12	2.923	3.7773	3.8876	5.8072	4.914	5.0299	0.705	-1.1745	-0.0013	0.4902	-0.9295	1.0193	-0.1445	-1.8817	0.1448	1.2249	-0.0908	-0.0769	1.4289	0.0196	1.0395	187.2894	109.6426	1.4952
13	5.8377	-5.8665	5.7702	6.971	-6.1335	5.9512	-0.3196	-1.9713	0.3912	-0.4894	0.2675	-1.0134	1.8673	-2.1731	0.0024	2.0915	-0.1055	0.274	1.8567	0.0029	1.8156	186.8582	108.0207	18.5483
14	6.0062	-2.1561	-1.7934	3.3269	1.6394	3.1976	-0.3738	-0.0441	-0.0139	0.0901	0.1924	-0.128	-0.2156	-0.2732	0.1841	1.6211	-0.132	-0.1395	1.062	0.0401	1.1402	165.0795	57.9308	34.5879
15	8.8253	6.2403	2.0623	4.7379	0.0618	6.0656	-0.0761	1.0485	0.7896	0.6158	0.9107	-0.1664	0.1226	-0.1385	-0.7064	1.6771	0.2206	-0.0197	1.3156	0.1053	1.2546	160.3835	67.1421	48.9802
16	1.291	-0.7242	-2.3583	3.8571	1.2567	1.8863	-0.6139	0.8722	-0.396	0.5823	0.3745	0.0444	1.4151	-1.0009	0.1913	1.9438	-0.3789	-0.081	1.6091	-0.0905	1.4318	162.8786	35.8672	30.3699
17	5.7488	-0.6122	-1.4204	6.3131	2.2973	3.15	-0.6046	0.3262	-0.5911	0.0192	0.2603	0.4287	2.3774	-1.3054	0.2664	2.4264	-0.5082	0.1716	1.9638	0.0005	1.5761	160.4913	29.5847	27.6828
18	8.7871	5.3836	-5.369	8.4935	-5.6504	4.7198	-0.4227	-0.101	-1.52	-1.3795	-0.7327	-0.7989	1.7656	1.5807	1.11	2.2788	0.1472	-0.0426	1.5324	0.1365	1.5304	171.4564	48.6194	55.4056
19	4.6575	1.4271	1.1323	5.4951	2.1012	2.8871	-0.2398	-1.0539	-0.467	0.7145	0.0688	0.285	0.6934	-0.0972	0.1738	1.8478	-0.0553	-0.0293	1.663	0.194	1.4039	158.7729	50.1753	57.0848
20	1.833	0.2826	-3.1268	5.7549	-1.4072	4.951	-0.0474	-0.3114	-0.6078	0.2493	-0.5646	0.3349	1.2879	-0.2861	0.5898	2.132	-0.0162	0.0768	1.3892	0.0001	1.3938	160.8047	41.7917	52.4301
21	4.5522	-1.0263	1.3698	1.8442	-3.6491	7.509	-0.868	0.2005	-2.2302	3.448	-1.3125	1.6167	5.5159	0.7074	1.948	3.9073	-1.0274	0.654	1.6543	-0.2983	2.0617	165.6507	15.69	25.6059
22	3.4711	-5.0556	-2.3226	9.5286	6.9032	6.4253	-0.3081	-1.0843	0.0922	1.1194	1.3254	0.5269	2.4621	-0.5728	-0.9717	2.8977	0.1631	0.2302	1.8026	0.5688	1.9489	166.7848	18.5697	41.0964
23	4.9985	-3.892	-2.8863	5.5993	6.2409	7.8095	-1.3355	-0.006	-0.5864	1.6855	0.303	0.1321	2.7779	0.0819	1.6491	3.1398	-0.0772	0.5422	1.4943	0.1735	1.9156	165.8384	18.791	37.1183
24	6.6615	-3.6098	-5.0546	3.7074	3.1604	5.0778	1.2866	-0.6481	-0.0539	-0.82	0.6658	-0.9632	0.1431	0.9392	-2.15	1.4277	-0.0433	-0.0704	1.4064	-0.0322	1.4043	158.7503	83.2072	52.293
25	4.5761	1.6903	0.2658	4.0828	0.0674	3.2098	-0.0325	-0.0286	-0.2854	-0.0767	0.1077	0.2499	0.6219	-0.3071	-0.0564	1.2948	-0.1442	-0.0993	1.2822	0.0447	1.232	136.7627	78.9898	59.0978
26	4.7345	3.6092	-4.7196	5.5783	-5.6451	5.8556	-1.3165	0.2349	-0.6084	-0.7738	0.7337	-1.35	1.4096	-0.7664	0.4429	1.2519	-0.2567	0.173	1.3502	-0.2356	1.3085	149.0561	83.2929	51.3907
27	5.9796	-5.2671	-2.2811	7.2644	-1.5229	4.876	0.7271	0.8391	-0.9807	-0.3094	-0.677	0.5668	0.7396	0.0988	0.1266	1.3569	-0.0935	-0.0999	1.5105	-0.0527	1.0724	147.6138	72.5141	48.758
28	3.2982	-1.5005	1.2718	3.871	2.218	3.6493	-1.1143	2.0947	0.3547	-3.7554	-0.4197	-3.406	-7.8784	-1.9399	1.2317	2.6738	0.0719	-0.0506	1.7853	-0.02	1.9664	140.505	90.4571	38.9559
29	1.9989	9.7467	0.09	7.3789	0.041	0.0045	-1.0197	5.2207	-3.268	-2.4659	0.9185	-2.3037	-0.3363	2.0841	-0.4363	0.9662	-0.0692	0.111	2.4328	-0.5801	1.3118	132.513	96.5242	31.4901
30	3.0598	-1.5947	0.8932	2.2084	-0.9134	3.5593	0.0821	0.266	-0.2961	0.0298	0.0196	0.5229	0.4947	-0.0123	-0.1993	1.1988	-0.2706	-0.0895	1.3133	0.0353	1.136	142.5102	84.6909	51.8381
31	5.6621	6.2299	3.0155	6.7029	3.281	2.964	1.3003	-0.9101	-1.3162	0.4518	-0.7205	-1.9384	0.9415	0.7317	-0.4923	1.0529	0.0153	0.0788	1.4	-0.0232	1.5805	158.951	98.0485	56.0001
32	3.5129	2.3757	-2.2575	5.1	-6.9021	9.6676	-0.0874	0.3382	-2.37	-0.7235	-0.7494	-0.1609	2.345	0.5794	0.7419	1.6729	-0.028	0.1398	2.0984	-0.1748	2.1958	174.4673	100.189	49.5441
33	5.3193	3.0053	-3.2031	6.2566	-4.9921	6.2261	-0.0369	0.5711	-0.2512	0.1728	-0.0586	-0.8302	0.4147	-0.3391	0.0999	1.1164	-0.1213	-0.1397	1.086	-0.0963	1.2008	171.2631	64.8512	3.2028
34	3.9857	0.2386	1.1792	1.2208	-0.3371	7.828	0.2608	0.012	0.1016	0.4784	-0.0361	-0.3252	-0.0122	0.1956	-0.2587	1.2025	-0.0842	-0.176	1.0156	-0.0491	1.3468	172.825	68.0415	8.8702
35	2.8072	-0.9599	4.1472	8.9891	1.2602	6.9198	1.0356	0.4447	0.7575	1.6893	-0.4	-0.2561	-0.5921	1.4991	-0.57	1.1933	-0.3217	0.0013	1.3289	-0.0798	1.2943	170.8461	82.7411	-1.0307
36	4.2026	3.6367	-3.1224	3.966	-4.0623	4.458	0.6806	0.04	-0.5383	-1.0195	-0.5629	0.3374	1.6556	1.4753	-0.2988	1.5193	-0.0845	-0.0145	1.1582	-0.0282	1.1254	166.0695	56.5927	5.3292
37	5.6676	-0.506	2.9456	7.982	-5.482	8.5829	1.4493	-0.0037	-1.3686	-1.8465	-0.6774	1.5297	1.912	0.7272	-0.6875	2.2695	0.0594	-0.5075	1.4486	-0.2185	1.9273	158.0108	39.1318	0.7396
38	8.6454	3.4967	0.8336	6.191	-3.6767	3.4616	0.1574	3.9157	0.4402	1.9858	-1.7726	-2.0116	5.9596	0.6934	0.9982	2.5403	0.3855	-0.1155	2.1499	-0.5014	1.4838	157.8428	41.8497	-13.2275
39	3.0436	-1.8093	-0.3028	6.9536	1.5413	0.4144	0.2551	0.4876	-0.8653	1.6739	-1.227	2.5844	2.7532	0.1998	0.8166	2.2656	0.2248	-0.2948	1.4977	0.0665	1.7449	153.7156	42.9663	2.2973
40	6.6528	1.032	-2.8912	4.2776	4.6886	7.5998	0.5254	2.3416	-1.4189	-0.9144	-1.5303	2.2449	1.4056	2.7264	1.1445	2.6432	0.3666	-0.0843	1.7184	-0.175	1.9047	165.9894	38.1807	-0.9415
41	7.3972	2.0221	2.2528	7.5677	5.4959	5.3608	0.3549	0.1972	-0.0938	-0.0456	-0.0908	0.25	0.1568	-0.528	-0.5904	1.3034	-0.1825	-0.0266	1.3349	-0.0277	1.006	146.6346	72.308	-5.1491
42	7.8265	1.5331	1.6981	7.3592	2.5209	5.8929	0.0067	0.5016	0.1531	-0.5802	-0.1277	0.404	-0.2243	-0.408	0.0822	1.0658	-0.0193	0.0035	1.1815	-0.0156	1.0229	159.1414	77.2372	-7.6563
43	7.2817	3.2527	6.5807	9.2633	3.5249	6.7528	0.1701	0.1923	-0.4382	-0.167	0.0276	0.4427	0.1723	-0.1986	-0.1494	1.0734	-0.097	0.0648	1.1458	0.0048	1.1316	151.2052	70.4181	-7.3449
44	1.9824	0.5031	1.3813	0.5072	1.0157	2.4188	-0.8273	0.3508	0.6001	0.0034	-0.0418	-0.2203	1.2687	0.6899	-5.9752	2.89	-1.184	-1.8128	1.5384	0.9268	3.9315	148.5648	30.6347	0.5877
45	3.6104	3.6814	-3.2081	9.2258	-8.0889	6.9634	0.382	-1.4697	-1.8065	-0.8986	1.2807	1.3102	0.8466	-1.2909	-1.4524	1.6602	-0.2686	-0.4015	1.8232	0.4821	2.6333	141.1937	43.835	-2.9066
46	6.1362	5.8582	-4.1187	5.5068	-4.1351	7.507	-0.7499	-0.5586	-4.0534	-0.0205	-0.5235	0.4605	0.3575	1.2496	0.8151	1.7629	-0.2356	-0.0352	1.8378	0.2959	3.0727	138.7385	40.4114	6.986
47	8.4407	0.1787	0.3324	6.0572	-5.1328	4.3704	0.6759	-0.6624	-2.3679	0.3294	-0.6331	-1.6503	0.8905	1.1521	-0.1312	1.8313	-0.0763	-0.4622	1.6429	-0.0289	2.3955	145.9257	42.4684	-1.3569
48	7.1458	-5.2331	7.1642	3.8956	-5.0274	6.8986	0.0684	0.0211	-0.8099	1.4015	-1.1615	-1.6909	-0.2961	-0.096	1.3326	1.965	-0.5275	-0.2691	1.8033	0.5609	3.125	132.9601	38.3642	-2.1342
49	9.0993	6.5816	2.4516	5.0783	2.7568	5.6422	-0.5462	-0.9311	-0.4237	-1.0951	-0.0541	-1.4389	-1.1225	-0.4511	0.496	1.1725	0.1052	0.0139	1.5335	0.1309	1.2695	147.3154	115.1136	39.5996
50	10.0296	-4.2364	2.4401	7.261	2.6642	3.0314	-0.5921	1.1832	-0.2721	-1.0174	0.0713	-0.6962	0.8931	1.9429	0.8112	1.7475	-0.2306	0.2259	1.7149	-0.007	1.4029	154.9983	110.4518	40.8626
51	1.7443	-2.5999	-0.1896	4.3589	-0.8968	3.0099	-0.0867	0.2037	0.2207	-0.3354	0.2427	1.1193	0.0385	-0.4511	-0.0604	1.0981	-0.0974	-0.0233	1.6503	0.0977	1.2215	125.4415	111.0763	46.037
52	8.4604	6.1203	-0.6332	5.105	1.8455	9.318	-1.0848	-1.0435	0.5291	-1.3754	-0.8005	1.8345	2.0472	-0.7194	2.3818	1.3632	-0.2603	-0.3446	2.2617	0.3859	1.7604	109.2278	99.2891	53.1776
53	5.5822	-3.3381	4.283	4.1258	-4.3412	9.2801	-0.8432	-1.4988	1.3556	-0.8897	1.4326	-0.4801	0.4935	-1.3714	-0.3257	1.0388	0.0426	0.0119	1.6954	-0.0853	1.4027	124.8437	114.0491	56.4089
54	7.9077	-0.9259	1.8669	2.5048	2.2966	2.8143	0.4365	-0.0262	-0.3463	-0.087	-0.3772	0.6279	-0.1383	-1.219	-0.1434	1.1001	-0.1087	-0.064	1.7418	0.1127	1.2954	120.0642	106.9552	48.657
55	5.6746	1.666	-1.7214	8.5634	-2.9343	9.1215	-0.3711	1.4431	1.1605	-0.8058	0.2436	-0.6755	0.4413	0.8053	0.1396	1.1067	-0.0385	0.1399	1.2286	0.2109	1.2849	139.9182	114.2642	45.4077
56	3.528	4.4149	-1.986	5.9522	0.2846	9.8751	-0.0039	0.2709	0.1904	-0.3648	-0.0653	0.4324	-1.0047	-0.6745	0.0103	1.1474	0.0233	0.0004	1.5644	0.0153	1.1264	133.3917	121.2624	39.8676
57	3.3623	1.251	-2.2324	9.506	3.7811	3.8268	0.9455	3.3821	4.6314	1.6997	-0.9763	-4.0959	-3.3431	0.2397	-0.6923	2.2044	0.15	-0.2288	2.6307	0.7021	2.6535	141.0986	121.9344	59.8639
58	4.1074	-3.0246	3.4194	5.2189	-0.6095	4.8549	-0.5928	-2.1618	2.7666	-2.1031	1.6518	-2.8086	-8.5125	3.4959	-1.0259	2.5126	-0.3039	0.3638	1.9399	-0.3263	1.6078	140.5266	126.2988	71.7792
59	0.2142	0.1227	-1.8205	2.3816	0.7285	5.5233	0.0203	-0.134	0.144	-0.2582	0.1822	0.2484	-0.2633	-0.1791	-0.1961	0.8522	0.0113	-0.0199	1.4535	-0.0485	1.3007	135.6098	113.2113	50.4772
60	5.3099	-3.8556	4.4022	4.1204	-1.4456	5.7541	-0.7192	2.391	-1.2594	-0.8916	0.0916	0.2639	-0.8196	0.6702	0.5332	1.2031	-0.2021	0.0255	1.5409	0.1659	1.1149	151.4949	104.0658	48.2328
61	3.4441	0.8912	4.0209	3.3526	1.7489	4.8067	-0.1644	0.4256	0.0885	-0.0545	1.0302	0.0032	-1.1447	1.5544	-0.9354	1.4672	-0.0247	0.2308	1.8109	0.2195	1.1841	167.6312	102.8909	42.6642
62	2.1737	1.8815	1.9071	9.0813	8.6619	9.4597	-1.2785	3.8817	-3.0599	-2.3558	1.5968	-2.41	0.2159	1.0524	-0.4977	1.8477	0.267	0.4297	2.2867	0.3812	1.8467	169.2973	110.8795	42.7353
63	8.8933	7.5719	-7.2181	7.0692	-4.976	7.5405	0.392	0.091	0.6072	0.9351	-0.3608	0.373	-0.5804	-0.965	-0.0888	1.3031	0.1701	0.0179	1.4373	0.1521	1.3323	138.4389	145.0435	26.7272
64	5.2114	1.1237	-4.9407	3.5699	1.0945	6.0669	0.1238	0.4103	0.6188	-0.9308	0.0202	-0.1333	1.2216	-1.1205	-0.3828	1.3396	-0.0038	0.0227	1.5539	0.1337	1.0314	140.1893	136.3718	18.9065
65	8.0479	1.9512	0.3882	6.87	-1.3352	8.4239	0.1601	-0.5817	0.033	-0.1177	0.0314	-0.4585	0.6296	-0.1643	-0.0635	1.141	0.1934	-0.0193	1.239	0.1015	1.1449	145.6906	139.705	23.6223
66	8.7334	-1.468	-5.0226	8.0119	5.0335	9.6284	-0.8436	-1.137	1.0315	0.4336	-0.2397	-0.701	2.7388	0.1327	0.9167	1.3205	0.0924	-0.0941	1.9132	0.2098	1.0927	139.9776	123.4885	27.838
67	3.0006	1.7322	-2.55	2.7738	-3.8937	5.7139	-0.0831	-0.2357	1.0527	1.2287	0.7507	0.0888	-0.8994	-1.1692	-1.043	1.2291	-0.0781	0.1143	1.7163	0.1415	1.4741	133.2351	139.5679	21.5406
68	3.6032	4.8438	2.2131	7.3873	1.7003	7.1399	-0.0584	-0.4642	2.3288	-1.5505	-0.8898	2.6103	-0.5378	-1.0651	0.8428	1.5362	0.164	-0.2631	1.766	-0.0747	2.0557	131.6811	160.1561	8.746
69	4.8907	5.6598	2.924	9.2515	0.224	5.0936	0.2961	-0.9397	1.7196	-0.8759	-0.6645	2.0327	-0.0504	-0.859	0.1773	1.7825	0.22	-0.1701	2.0655	0.02	2.2923	121.9742	156.3754	6.5779
70	4.3974	-5.5432	4.4104	6.6515	-5.5166	4.9196	1.7935	-0.3163	-1.0482	0.5196	-1.4842	1.5554	0.0601	-1.3611	-0.4937	1.6875	0.2818	0.0684	2.2431	-0.2283	2.9655	121.7127	164.3683	13.8625
71	9.8398	-4.8017	3.777	4.3569	1.0447	5.1645	-0.2735	2.678	-0.456	-0.9254	-0.0687	1.2825	0.505	0.0355	0.1465	1.7472	-0.1612	-0.1791	1.9971	0.1098	1.6371	126.568	125.839	4.8883
72	2.3333	-2.763	-0.0796	9.0062	0.8153	2.362	-0.2584	0.0454	-0.2493	-0.2706	0.0373	0.644	0.6532	-1.0467	0.1885	1.435	-0.2356	0.0185	1.8349	0.0751	1.4189	128.4862	123.2058	16.8297
73	9.6542	-5.7166	6.5527	8.0012	-6.1758	6.6363	-0.2465	1.3582	-1.1484	-0.1597	0.3354	1.3445	0.0129	-0.3485	-0.0021	1.5045	-0.114	0.0856	1.684	-0.0667	1.3581	129.3683	128.9934	12.7065
74	2.6589	2.8688	2.6863	3.4191	3.5408	3.5285	0.0708	0.6716	2.5723	-0.4388	-1.7733	-0.5745	-0.6632	-1.136	1.4493	1.6108	0.0045	-0.6681	2.4318	0.1385	2.664	114.2338	145.5111	-1.6696
75	4.9302	3.7569	5.1134	5.2761	5.3043	5.9041	-0.8178	-0.2001	1.4901	-2.8875	0.1033	1.8417	-0.8513	-0.6012	0.8034	2.1203	0.0568	-0.2663	2.5217	0.2739	2.2744	120.9626	159.2585	-5.1215
76	3.7374	2.7974	-3.0607	2.9671	-1.6503	3.2615	-1.8854	-0.2077	0.1684	-1.5253	2.0793	1.9577	1.3825	-4.0468	-0.1126	1.7379	-0.2224	-0.2522	2.6313	0.5015	2.104	118.6737	146.1257	1.9046
77	8.4647	5.7601	5.5194	5.32	4.9535	6.9822	-2.0241	1.9631	1.7968	3.3189	2.308	-4.0574	-1.1555	1.5386	-0.5599	2.9786	0.0369	-1.1214	2.0895	0.307	3.4926	126.2983	165.2421	-8.7683
78	4.4461	3.3487	0.062	2.5193	0.612	1.1971	-1.1331	1.8483	1.6437	-0.0702	0.0258	-0.8728	-1.156	0.6061	1.1431	2.9827	-0.2149	-1.2044	2.185	0.7169	2.8571	116.0006	160.395	-13.4032
79	4.4434	-3.1617	5.0513	9.2645	-2.3	9.4625	-0.3721	2.3981	0.6555	1.4006	-0.2852	-0.4493	-0.0044	1.9084	0.4805	1.1026	-0.0649	0.0448	1.5504	-0.1243	1.1122	160.1734	111.2788	72.1946
80	3.3375	0.9632	-1.3327	3.1363	-3.8723	7.9794	-0.793	1.2341	0.8352	-1.2994	0.7667	-0.721	-0.7292	1.9152	-0.0198	1.3435	-0.1898	-0.3532	1.7003	-0.3412	1.8437	163.7539	111.4806	63.1985
81	2.7609	1.6788	-1.1388	1.1805	-1.0625	6.0684	-0.3498	-0.3158	-0.0493	0.296	0.3083	0.4254	0.2937	-0.7	0.0177	1.1291	-0.1232	0.0435	1.2399	0.0037	1.2119	136.347	106.9398	81.5717
82	2.553	1.8099	-2.8689	8.166	-1.6234	8.2689	-0.0201	-0.048	-0.3018	0.7467	-0.1072	0.6864	0.2673	-0.8728	0.1365	1.0566	-0.0749	0.0542	1.4927	0.1046	1.0911	133.4367	104.3537	81.1778
83	0.936	-0.2418	0.6442	4.2953	3.8419	6.2337	0.2674	-0.2193	0.2059	0.0287	-0.1065	-1.0138	0.319	0.3673	-0.1025	0.9069	-0.0691	-0.0257	1.3694	-0.0294	1.0808	152.4787	106.1516	74.4763
84	7.7582	3.2622	2.6673	9.5329	6.5214	4.3814	0.2142	-0.3589	0.5178	0.5442	-0.1752	0.4245	0.3766	-0.2864	0.0787	1.1606	-0.2137	0.1114	1.2125	0.011	1.1498	153.1338	108.2283	85.4406
85	2.0079	-7.7105	-6.6226	6.8669	-1.3479	2.0014	1.5142	-2.8057	2.4176	1.3222	-0.8156	-4.2348	-0.0237	8.2277	-1.1873	1.538	-0.0234	-0.1532	3.1704	-0.3581	1.3708	152.5604	89.7891	74.2144
86	8.0262	2.0993	-6.2551	5.0019	-4.5153	7.2753	1.8578	-1.5319	-1.0473	3.396	-0.8097	-4.231	-1.4647	0.5529	-1.0018	1.2449	0.0373	-0.0589	1.6084	0.0919	1.5537	152.4054	77.3522	74.146
87	1.522	1.001	1.1043	5.2118	0.3347	1.1782	0.0133	-0.0966	-0.255	0.1646	0.0089	0.1225	0.1659	-0.3367	0.0171	1.1415	-0.0405	0.172	1.3271	0.0117	1.0546	147.1516	102.0497	75.0157
88	6.886	6.2872	-5.7412	9.4831	-6.3767	5.2	1.1728	0.2652	1.1545	1.0408	0.2995	0.1839	-1.4788	0.4386	-1.3638	1.0859	-0.1459	0.0848	1.593	-0.134	1.0523	154.7028	107.7917	59.184
89	1.8148	4.1724	3.9711	9.6165	9.1708	8.7459	-2.5369	-0.0352	0.7656	-3.6	0.077	-1.2297	-0.2892	-0.1512	2.513	0.9948	-0.3879	0.0039	1.9599	-0.0306	1.1702	163.7051	111.0676	49.5476
90	1.398	1.4215	3.0525	2.9573	4.5879	8.8105	1.1096	-0.7579	0.2608	-2.621	1.2942	-2.5737	-1.6607	2.345	-2.6814	1.246	0.0267	0.0638	1.838	-0.2136	2.4902	172.0463	115.9599	50.3276
91	4.6711	-3.289	-3.2122	7.796	1.3834	3.5903	-0.0472	2.6895	1.2125	0.0775	-0.6143	-0.1258	-3.599	1.7758	1.0336	1.745	-0.4905	-0.0327	2.5944	0.0086	1.6662	173.7176	109.924	54.115
92	8.3142	1.0489	2.9511	4.7355	1.0159	1.0474	0.5513	-1.004	-1.0531	0.2641	-0.2076	-0.0018	0.5285	-0.0968	-0.3773	1.3522	0.1151	0.0415	1.2797	0.0498	0.9106	178.4878	111.805	106.1536
93	7.8937	0.1615	0.01	2.939	0.234	4.1322	0.005	0.3659	0.0604	-0.3817	-0.1289	0.246	0.0356	0.2064	0.1153	1.1192	0.0685	-0.028	1.0263	0.0102	0.9382	175.192	115.0835	96.8616
94	5.1161	1.8319	5.0604	3.8328	1.6131	6.0982	0.5109	0.4124	-1.2833	-0.5072	0.1875	0.2307	0.7121	0.8421	-0.7309	1.0811	0.0312	0.0284	1.2223	-0.0807	1.216	165.5719	117.4232	94.7662
95	5.4972	-4.8594	-4.6886	7.7707	0.8792	7.1754	-1.3599	-1.8094	-1.2891	1.8214	1.1873	1.0945	-0.3063	0.3903	0.0674	1.6622	0.3309	0.1788	1.7082	0.1399	1.2738	180.7493	119.0858	125.5471
96	4.6264	2.3239	-1.4161	5.9093	-1.8588	3.817	-0.0484	-0.4403	-2.3168	2.9309	-0.0902	-0.9531	-1.0809	0.4218	0.0827	1.814	0.2654	-0.0117	1.5382	0.047	1.5002	176.5575	125.1394	126.5303
97	4.7729	0.2695	-2.2487	3.6308	3.3824	4.1946	-2.4387	-1.9166	-2.9104	1.3756	0.8269	2.4368	0.3027	0.3021	1.0205	2.233	0.7689	0.5186	2.3898	0.6979	1.7039	178.7316	113.5548	130.7568
98	5.271	0.3281	-2.3471	5.0684	-2.7079	5.7808	-0.1759	-0.3	0.4524	0.541	0.2323	0.2597	-0.4994	0.273	0.03	1.2604	0.066	0.0796	1.273	-0.044	1.0493	160.6956	137.8267	104.1845
99	4.4677	-0.5727	1.0874	4.2313	1.9116	8.7707	-0.0841	-0.0193	0.0347	-0.0299	0.0201	0.5334	0.1198	-0.5171	0.0119	1.0253	-0.0174	0.0665	1.0617	0.0565	1.1662	158.7924	128.6512	98.7386
100	4.7676	0.1983	4.9037	1.4212	-1.9685	6.9701	-0.9798	-1.8252	1.0582	2.118	1.724	0.3379	-1.9506	0.981	5.9682	2.1155	0.5269	-0.274	2.9157	-0.9331	0.8889	172.0163	132.2167	131.1224
101	5.9754	-0.969	5.5693	5.8917	1.3854	5.7029	-0.6131	-1.7206	0.9153	0.9487	0.9467	-1.2673	-1.6844	0.2544	-0.2426	1.9257	0.5324	0.0108	1.9977	-0.277	1.9066	174.5378	137.655	131.9087
102	3.0966	0.2832	2.7959	5.9528	0.7887	7.4234	-1.3454	-0.978	-1.691	1.3975	1.4441	-1.9626	-0.6913	0.5272	-0.0615	2.1286	0.4842	-0.3157	1.897	-0.3376	1.7117	177.6592	134.6067	129.4558
103	5.9498	-1.6796	-6.0084	0.952	1.4235	6.7093	1.2627	-1.0383	1.5987	-0.6574	-0.075	-0.7727	0.7749	2.037	-1.2612	2.3331	0.4239	-0.7139	1.8834	-0.8316	2.0538	178.5385	141.1013	139.9173

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	( CHAIN C AND RESID 31:45 )	C	31 - 45
2	X-RAY DIFFRACTION	2	( CHAIN C AND RESID 46:59 )	C	46 - 59
3	X-RAY DIFFRACTION	3	( CHAIN C AND RESID 60:124 )	C	60 - 124
4	X-RAY DIFFRACTION	4	( CHAIN C AND RESID 125:144 )	C	125 - 144
5	X-RAY DIFFRACTION	5	( CHAIN C AND RESID 145:158 )	C	145 - 158
6	X-RAY DIFFRACTION	6	( CHAIN C AND RESID 159:176 )	C	159 - 176
7	X-RAY DIFFRACTION	7	( CHAIN C AND RESID 177:189 )	C	177 - 189
8	X-RAY DIFFRACTION	8	( CHAIN D AND RESID 504:519 )	D	504 - 519
9	X-RAY DIFFRACTION	9	( CHAIN D AND RESID 520:524 )	D	520 - 524
10	X-RAY DIFFRACTION	10	( CHAIN D AND RESID 525:529 )	D	525 - 529
11	X-RAY DIFFRACTION	11	( CHAIN D AND RESID 530:583 )	D	530 - 583
12	X-RAY DIFFRACTION	12	( CHAIN D AND RESID 584:601 )	D	584 - 601
13	X-RAY DIFFRACTION	13	( CHAIN D AND RESID 602:613 )	D	602 - 613
14	X-RAY DIFFRACTION	14	( CHAIN E AND RESID 1:95 )	E	1 - 95
15	X-RAY DIFFRACTION	15	( CHAIN E AND RESID 96:100 )	E	96 - 100
16	X-RAY DIFFRACTION	16	( CHAIN E AND RESID 101:137 )	E	101 - 137
17	X-RAY DIFFRACTION	17	( CHAIN E AND RESID 138:221 )	E	138 - 221
18	X-RAY DIFFRACTION	18	( CHAIN F AND RESID 1:9 )	F	1 - 9
19	X-RAY DIFFRACTION	19	( CHAIN F AND RESID 10:75 )	F	10 - 75
20	X-RAY DIFFRACTION	20	( CHAIN F AND RESID 76:113 )	F	76 - 113
21	X-RAY DIFFRACTION	21	( CHAIN F AND RESID 114:129 )	F	114 - 129
22	X-RAY DIFFRACTION	22	( CHAIN F AND RESID 130:158 )	F	130 - 158
23	X-RAY DIFFRACTION	23	( CHAIN F AND RESID 159:211 )	F	159 - 211
24	X-RAY DIFFRACTION	24	( CHAIN G AND RESID 31:45 )	G	31 - 45
25	X-RAY DIFFRACTION	25	( CHAIN G AND RESID 46:176 )	G	46 - 176
26	X-RAY DIFFRACTION	26	( CHAIN G AND RESID 177:188 )	G	177 - 188
27	X-RAY DIFFRACTION	27	( CHAIN H AND RESID 504:519 )	H	504 - 519
28	X-RAY DIFFRACTION	28	( CHAIN H AND RESID 520:524 )	H	520 - 524
29	X-RAY DIFFRACTION	29	( CHAIN H AND RESID 525:529 )	H	525 - 529
30	X-RAY DIFFRACTION	30	( CHAIN H AND RESID 530:583 )	H	530 - 583
31	X-RAY DIFFRACTION	31	( CHAIN H AND RESID 584:601 )	H	584 - 601
32	X-RAY DIFFRACTION	32	( CHAIN H AND RESID 602:613 )	H	602 - 613
33	X-RAY DIFFRACTION	33	( CHAIN I AND RESID 1:51 )	I	1 - 51
34	X-RAY DIFFRACTION	34	( CHAIN I AND RESID 52:95 )	I	52 - 95
35	X-RAY DIFFRACTION	35	( CHAIN I AND RESID 96:100 )	I	96 - 100
36	X-RAY DIFFRACTION	36	( CHAIN I AND RESID 101:118 )	I	101 - 118
37	X-RAY DIFFRACTION	37	( CHAIN I AND RESID 119:157 )	I	119 - 157
38	X-RAY DIFFRACTION	38	( CHAIN I AND RESID 162:173 )	I	162 - 173
39	X-RAY DIFFRACTION	39	( CHAIN I AND RESID 174:207 )	I	174 - 207
40	X-RAY DIFFRACTION	40	( CHAIN I AND RESID 208:222 )	I	208 - 222
41	X-RAY DIFFRACTION	41	( CHAIN J AND RESID 1:24 )	J	1 - 24
42	X-RAY DIFFRACTION	42	( CHAIN J AND RESID 25:61 )	J	25 - 61
43	X-RAY DIFFRACTION	43	( CHAIN J AND RESID 62:113 )	J	62 - 113
44	X-RAY DIFFRACTION	44	( CHAIN J AND RESID 114:128 )	J	114 - 128
45	X-RAY DIFFRACTION	45	( CHAIN J AND RESID 129:150 )	J	129 - 150
46	X-RAY DIFFRACTION	46	( CHAIN J AND RESID 151:163 )	J	151 - 163
47	X-RAY DIFFRACTION	47	( CHAIN J AND RESID 164:187 )	J	164 - 187
48	X-RAY DIFFRACTION	48	( CHAIN J AND RESID 188:206 )	J	188 - 206
49	X-RAY DIFFRACTION	49	( CHAIN K AND RESID 32:44 )	K	32 - 44
50	X-RAY DIFFRACTION	50	( CHAIN K AND RESID 45:59 )	K	45 - 59
51	X-RAY DIFFRACTION	51	( CHAIN K AND RESID 60:114 )	K	60 - 114
52	X-RAY DIFFRACTION	52	( CHAIN K AND RESID 115:124 )	K	115 - 124
53	X-RAY DIFFRACTION	53	( CHAIN K AND RESID 125:136 )	K	125 - 136
54	X-RAY DIFFRACTION	54	( CHAIN K AND RESID 137:176 )	K	137 - 176
55	X-RAY DIFFRACTION	55	( CHAIN K AND RESID 177:188 )	K	177 - 188
56	X-RAY DIFFRACTION	56	( CHAIN L AND RESID 504:519 )	L	504 - 519
57	X-RAY DIFFRACTION	57	( CHAIN L AND RESID 520:524 )	L	520 - 524
58	X-RAY DIFFRACTION	58	( CHAIN L AND RESID 525:529 )	L	525 - 529
59	X-RAY DIFFRACTION	59	( CHAIN L AND RESID 530:583 )	L	530 - 583
60	X-RAY DIFFRACTION	60	( CHAIN L AND RESID 584:596 )	L	584 - 596
61	X-RAY DIFFRACTION	61	( CHAIN L AND RESID 597:606 )	L	597 - 606
62	X-RAY DIFFRACTION	62	( CHAIN L AND RESID 607:613 )	L	607 - 613
63	X-RAY DIFFRACTION	63	( CHAIN M AND RESID 1:31 )	M	1 - 31
64	X-RAY DIFFRACTION	64	( CHAIN M AND RESID 32:51 )	M	32 - 51
65	X-RAY DIFFRACTION	65	( CHAIN M AND RESID 52:95 )	M	52 - 95
66	X-RAY DIFFRACTION	66	( CHAIN M AND RESID 96:100 )	M	96 - 100
67	X-RAY DIFFRACTION	67	( CHAIN M AND RESID 101:108 )	M	101 - 108
68	X-RAY DIFFRACTION	68	( CHAIN M AND RESID 109:157 )	M	109 - 157
69	X-RAY DIFFRACTION	69	( CHAIN M AND RESID 162:194 )	M	162 - 194
70	X-RAY DIFFRACTION	70	( CHAIN M AND RESID 195:222 )	M	195 - 222
71	X-RAY DIFFRACTION	71	( CHAIN N AND RESID 1:24 )	N	1 - 24
72	X-RAY DIFFRACTION	72	( CHAIN N AND RESID 25:75 )	N	25 - 75
73	X-RAY DIFFRACTION	73	( CHAIN N AND RESID 76:102 )	N	76 - 102
74	X-RAY DIFFRACTION	74	( CHAIN N AND RESID 103:118 )	N	103 - 118
75	X-RAY DIFFRACTION	75	( CHAIN N AND RESID 119:158 )	N	119 - 158
76	X-RAY DIFFRACTION	76	( CHAIN N AND RESID 159:174 )	N	159 - 174
77	X-RAY DIFFRACTION	77	( CHAIN N AND RESID 175:187 )	N	175 - 187
78	X-RAY DIFFRACTION	78	( CHAIN N AND RESID 188:211 )	N	188 - 211
79	X-RAY DIFFRACTION	79	( CHAIN O AND RESID 32:45 )	O	32 - 45
80	X-RAY DIFFRACTION	80	( CHAIN O AND RESID 46:59 )	O	46 - 59
81	X-RAY DIFFRACTION	81	( CHAIN O AND RESID 60:124 )	O	60 - 124
82	X-RAY DIFFRACTION	82	( CHAIN O AND RESID 125:176 )	O	125 - 176
83	X-RAY DIFFRACTION	83	( CHAIN O AND RESID 177:188 )	O	177 - 188
84	X-RAY DIFFRACTION	84	( CHAIN P AND RESID 504:519 )	P	504 - 519
85	X-RAY DIFFRACTION	85	( CHAIN P AND RESID 520:524 )	P	520 - 524
86	X-RAY DIFFRACTION	86	( CHAIN P AND RESID 525:529 )	P	525 - 529
87	X-RAY DIFFRACTION	87	( CHAIN P AND RESID 530:583 )	P	530 - 583
88	X-RAY DIFFRACTION	88	( CHAIN P AND RESID 584:596 )	P	584 - 596
89	X-RAY DIFFRACTION	89	( CHAIN P AND RESID 597:601 )	P	597 - 601
90	X-RAY DIFFRACTION	90	( CHAIN P AND RESID 602:606 )	P	602 - 606
91	X-RAY DIFFRACTION	91	( CHAIN P AND RESID 607:613 )	P	607 - 613
92	X-RAY DIFFRACTION	92	( CHAIN A AND RESID 1:19 )	A	1 - 19
93	X-RAY DIFFRACTION	93	( CHAIN A AND RESID 20:95 )	A	20 - 95
94	X-RAY DIFFRACTION	94	( CHAIN A AND RESID 96:108 )	A	96 - 108
95	X-RAY DIFFRACTION	95	( CHAIN A AND RESID 109:166 )	A	109 - 166
96	X-RAY DIFFRACTION	96	( CHAIN A AND RESID 167:207 )	A	167 - 207
97	X-RAY DIFFRACTION	97	( CHAIN A AND RESID 208:227 )	A	208 - 227
98	X-RAY DIFFRACTION	98	( CHAIN B AND RESID 1:24 )	B	1 - 24
99	X-RAY DIFFRACTION	99	( CHAIN B AND RESID 25:102 )	B	25 - 102
100	X-RAY DIFFRACTION	100	( CHAIN B AND RESID 103:128 )	B	103 - 128
101	X-RAY DIFFRACTION	101	( CHAIN B AND RESID 129:152 )	B	129 - 152
102	X-RAY DIFFRACTION	102	( CHAIN B AND RESID 153:187 )	B	153 - 187
103	X-RAY DIFFRACTION	103	( CHAIN B AND RESID 188:211 )	B	188 - 211

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