Entry Database : PDB / ID : 5gtu Structure visualization Downloads & linksTitle Structural and mechanistic insights into regulation of the retromer coat by TBC1d5 ComponentsTBC1 domain family member 5 Vacuolar protein sorting-associated protein 29 DetailsKeywords HYDROLASE / complex / cellular trafficking / endosomal sortingFunction / homology Function and homology informationFunction Domain/homology Component
retromer, cargo-selective complex / WNT ligand biogenesis and trafficking / retromer complex binding / AP-2 adaptor complex binding / retromer complex / endocytic recycling / retrograde transport, endosome to Golgi / activation of GTPase activity / response to starvation / positive regulation of receptor internalization ... retromer, cargo-selective complex / WNT ligand biogenesis and trafficking / retromer complex binding / AP-2 adaptor complex binding / retromer complex / endocytic recycling / retrograde transport, endosome to Golgi / activation of GTPase activity / response to starvation / positive regulation of receptor internalization / autophagosome / GTPase activator activity / macroautophagy / intracellular protein transport / autophagy / late endosome / early endosome / endosome membrane / endosome / intracellular membrane-bounded organelle / protein-containing complex binding / Golgi apparatus / metal ion binding / cytosol Similarity search - Function Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. / Rab-GTPase-TBC domain / Rab-GTPase-TBC domain superfamily / Rab-GTPase-TBC domain / TBC/rab GAP domain profile. / Vacuolar protein sorting-associated protein 29 / Phosphodiesterase MJ0936/Vps29 / Calcineurin-like phosphoesterase domain, lpxH-type / Calcineurin-like phosphoesterase superfamily domain / Metallo-dependent phosphatases ... Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. / Rab-GTPase-TBC domain / Rab-GTPase-TBC domain superfamily / Rab-GTPase-TBC domain / TBC/rab GAP domain profile. / Vacuolar protein sorting-associated protein 29 / Phosphodiesterase MJ0936/Vps29 / Calcineurin-like phosphoesterase domain, lpxH-type / Calcineurin-like phosphoesterase superfamily domain / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Metallo-dependent phosphatase-like / 4-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.5 Å DetailsAuthors Jia, D. / Rosen, M. Funding support United States, China, 4items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01-GM056322 United States Howard Hughes Medical Institute United States CNSF Junior One Thousand Talents program China Welch Foundation I-1544 United States
CitationJournal : Nat Commun / Year : 2016Title : Structural and mechanistic insights into regulation of the retromer coat by TBC1d5Authors : Jia, D. / Zhang, J.S. / Li, F. / Wang, J. / Deng, Z. / White, M.A. / Osborne, D.G. / Phillips-Krawczak, C. / Gomez, T.S. / Li, H. / Singla, A. / Burstein, E. / Billadeau, D.D. / Rosen, M.K. History Deposition Aug 23, 2016 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Dec 7, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Oct 18, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Mar 23, 2022 Group : Author supporting evidence / Database references / Category : database_2 / pdbx_audit_supportItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organizationRevision 1.3 Nov 8, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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