Entry Database : PDB / ID : 5ftg Structure visualization Downloads & linksTitle Human choline kinase a1 in complex with compound 1-[[4-[2-[4-[[4-(dimethylamino)pyridin-1- yl]methyl]phenoxy]ethoxy]phenyl]methyl]-N,N- dimethyl-pyridin-4-amine (compound 10a) ComponentsCHOLINE KINASE ALPHA Details Keywords TRANSFERASE / BISCATIONIC INHIBITOR / DOCKING STUDIESFunction / homology Function and homology informationFunction Domain/homology Component
ethanolamine kinase / choline kinase / ethanolamine kinase activity / CDP-choline pathway / choline kinase activity / Synthesis of PE / phosphatidylethanolamine biosynthetic process / lipid droplet disassembly / phosphatidylcholine biosynthetic process / cholinesterase activity ... ethanolamine kinase / choline kinase / ethanolamine kinase activity / CDP-choline pathway / choline kinase activity / Synthesis of PE / phosphatidylethanolamine biosynthetic process / lipid droplet disassembly / phosphatidylcholine biosynthetic process / cholinesterase activity / lipid transport / Synthesis of PC / cellular response to glucose starvation / lipid droplet / lipid metabolic process / protein tyrosine kinase activity / phosphorylation / protein homodimerization activity / ATP binding / cytoplasm / cytosol Similarity search - Function Choline/ethanolamine kinase / Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 / Aminoglycoside phosphotransferase (APH), C-terminal lobe / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase-like domain superfamily / Alpha-Beta Complex / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.45 Å DetailsAuthors Schiaffino-Ortega, S. / Baglioni, E. / Mariotto, E. / Bortolozzi, R. / Serran-Aguilera, L. / Rios-Marco, P. / Carrasco-Jimenez, M.P. / Gallo, M.A. / Hurtado-Guerrero, R. / Marco, C. ...Schiaffino-Ortega, S. / Baglioni, E. / Mariotto, E. / Bortolozzi, R. / Serran-Aguilera, L. / Rios-Marco, P. / Carrasco-Jimenez, M.P. / Gallo, M.A. / Hurtado-Guerrero, R. / Marco, C. / Basso, G. / Viola, G. / Entrena, A. / Lopez-Cara, L.C. CitationJournal : Sci.Rep. / Year : 2016Title : Design, Synthesis, Crystallization and Biological Evaluation of New Symmetrical Biscationic Compounds as Selective Inhibitors of Human Choline Kinase Alpha1 (Chokalpha1)Authors: Schiaffino-Ortega, S. / Baglioni, E. / Mariotto, E. / Bortolozzi, R. / Serran-Aguilera, L. / Rios-Marco, P. / Carrasco-Jimenez, M.P. / Gallo, M.A. / Hurtado-Guerrero, R. / Marco, C. / Basso, ... Authors : Schiaffino-Ortega, S. / Baglioni, E. / Mariotto, E. / Bortolozzi, R. / Serran-Aguilera, L. / Rios-Marco, P. / Carrasco-Jimenez, M.P. / Gallo, M.A. / Hurtado-Guerrero, R. / Marco, C. / Basso, G. / Viola, G. / Entrena, A. / Lopez-Cara, L.C. History Deposition Jan 13, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 23, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Apr 13, 2016 Group : Database referencesRevision 1.2 Dec 7, 2016 Group : Structure summaryRevision 2.0 Oct 23, 2019 Group : Data collection / Non-polymer description / Other / Category : chem_comp / pdbx_database_statusItem : _chem_comp.formula / _pdbx_database_status.status_code_sfRevision 2.1 Jan 10, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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