Entry Database : PDB / ID : 5flv Structure visualization Downloads & linksTitle Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region Components5'-D(*AP*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP *GP*TP*GP*AP*GP*AP*AP*G)-3'5'-D(*TP*CP*TP*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP *TP*GP*AP*AP*GP*TP*GP*G)-3'HOMEOBOX PROTEIN NKX-2.5, T-BOX TRANSCRIPTION FACTOR TBX5 DetailsKeywords TRANSCRIPTIONFunction / homology Function and homology informationFunction Domain/homology Component
: / Purkinje myocyte differentiation / right ventricular cardiac muscle tissue morphogenesis / septum secundum development / proepicardium development / pulmonary myocardium development / cardiac ventricle formation / apoptotic process involved in heart morphogenesis / atrioventricular node cell fate commitment / bundle of His development ... : / Purkinje myocyte differentiation / right ventricular cardiac muscle tissue morphogenesis / septum secundum development / proepicardium development / pulmonary myocardium development / cardiac ventricle formation / apoptotic process involved in heart morphogenesis / atrioventricular node cell fate commitment / bundle of His development / atrial cardiac muscle cell development / ventricular cardiac myofibril assembly / atrioventricular node cell development / embryonic heart tube left/right pattern formation / positive regulation of cardioblast differentiation / atrial cardiac muscle tissue development / positive regulation of heart contraction / atrioventricular node development / ventricular cardiac muscle cell development / regulation of cardiac muscle cell proliferation / atrial septum morphogenesis / cardiac ventricle morphogenesis / negative regulation of myotube differentiation / circulatory system development / cardiac conduction system development / pharyngeal system development / endoderm development / positive regulation of sodium ion transport / cardiac muscle cell differentiation / outflow tract septum morphogenesis / cardiac muscle tissue morphogenesis / ventricular trabecula myocardium morphogenesis / heart trabecula formation / adult heart development / embryonic heart tube development / cardiac muscle tissue development / cardiac muscle cell development / cardiac muscle cell proliferation / negative regulation of cardiac muscle cell apoptotic process / tongue development / DNA-binding transcription activator activity / ventricular septum morphogenesis / sarcomere organization / heart contraction / heart looping / outflow tract morphogenesis / thyroid gland development / transcription factor binding / hemopoiesis / regulation of cardiac muscle contraction / regulation of cardiac conduction / positive regulation of transcription initiation by RNA polymerase II / vasculogenesis / heart morphogenesis / cardiac muscle contraction / spleen development / positive regulation of neuron differentiation / protein-DNA complex / negative regulation of canonical Wnt signaling pathway / histone deacetylase binding / RNA polymerase II transcription regulator complex / sequence-specific double-stranded DNA binding / heart development / DNA-binding transcription activator activity, RNA polymerase II-specific / transcription regulator complex / sequence-specific DNA binding / cell differentiation / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / chromatin binding / positive regulation of cell population proliferation / positive regulation of gene expression / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / identical protein binding / nucleus / cytoplasm Similarity search - Function Homeobox protein NKX-2.5 / Transcription factor, T-box / T-box / Homeobox domain, metazoa / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain ... Homeobox protein NKX-2.5 / Transcription factor, T-box / T-box / Homeobox domain, metazoa / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A / Immunoglobulin-like / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species MUS MUSCULUS (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.005 Å DetailsAuthors Stirnimann, C.U. / Glatt, S. / Mueller, C.W. CitationJournal : Cell(Cambridge,Mass.) / Year : 2016Title : Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.Authors: Luna-Zurita, L. / Stirnimann, C.U. / Glatt, S. / Kaynak, B.L. / Thomas, S. / Baudin, F. / Samee, M.A.H. / He, D. / Small, E.M. / Mileikovsky, M. / Nagy, A. / Holloway, A.K. / Pollard, K.S. / ... Authors : Luna-Zurita, L. / Stirnimann, C.U. / Glatt, S. / Kaynak, B.L. / Thomas, S. / Baudin, F. / Samee, M.A.H. / He, D. / Small, E.M. / Mileikovsky, M. / Nagy, A. / Holloway, A.K. / Pollard, K.S. / Muller, C.W. / Bruneau, B.G. History Deposition Oct 28, 2015 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 10, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Aug 17, 2016 Group : Database referencesRevision 1.2 Jan 10, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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