Entry | Database: PDB / ID: 5f5g |
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Title | Structure of E.Coli GlpG Y205F mutant complexed with peptidic inhibitor Ac-RMA-CHO in the DMPC/CHAPSO bicelle |
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Components | - ACE-ARG-MET-ALA-aldehyde
- Rhomboid protease GlpG
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / GlpG / Rhomboid / intramembrane protease / Bicelle / HYDROLASE-HYDROLASE INHIBITOR complex |
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Function / homology | Function and homology information
rhomboid protease / endopeptidase activity / serine-type endopeptidase activity / proteolysis / identical protein binding / plasma membraneSimilarity search - Function Rhomboid-like fold / Rhomboid-like / Peptidase S54, GlpG peptidase, N-terminal / Rhomboid protease GlpG / GlpG peptidase, N-terminal domain superfamily / Cytoplasmic N-terminal domain of rhomboid serine protease / Peptidase S54, rhomboid domain / Rhomboid family / Rhomboid-like superfamily / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli)
![](img/tx_arthropod.gif) Drosophila melanogaster (fruit fly) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 2.3 Å |
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Authors | Urban, S. / Cho, S. / Dickey, S.W. |
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Citation | Journal: Mol.Cell / Year: 2016 Title: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Authors: Cho, S. / Dickey, S.W. / Urban, S. |
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History | Deposition | Dec 4, 2015 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Apr 6, 2016 | Provider: repository / Type: Initial release |
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Revision 2.0 | Jul 10, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Polymer sequence Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / entity_poly / pdbx_struct_oper_list / struct_conn Item: _citation.journal_id_CSD / _database_2.pdbx_DOI ..._citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity_poly.pdbx_seq_one_letter_code_can / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.pdbx_leaving_atom_flag |
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