登録情報 | データベース: PDB / ID: 5ep6 |
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タイトル | The crystal structure of NAP1 in complex with TBK1 |
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要素 | - 5-azacytidine-induced protein 2
- Serine/threonine-protein kinase TBK1
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キーワード | PROTEIN BINDING/TRANSFERASE / NAP1 / TBK1 / CALCOCO2 / PROTEIN BINDING-TRANSFERASE complex |
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機能・相同性 | 機能・相同性情報
IRF3 mediated activation of type 1 IFN / STAT6-mediated induction of chemokines / positive regulation of xenophagy / serine/threonine protein kinase complex / dendritic cell differentiation / regulation of type I interferon production / dendritic cell proliferation / cGAS/STING signaling pathway / IRF3-mediated induction of type I IFN / Interleukin-37 signaling ...IRF3 mediated activation of type 1 IFN / STAT6-mediated induction of chemokines / positive regulation of xenophagy / serine/threonine protein kinase complex / dendritic cell differentiation / regulation of type I interferon production / dendritic cell proliferation / cGAS/STING signaling pathway / IRF3-mediated induction of type I IFN / Interleukin-37 signaling / positive regulation of type I interferon-mediated signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / TNFR1-induced proapoptotic signaling / toll-like receptor 4 signaling pathway / TRAF6 mediated IRF7 activation / type I interferon-mediated signaling pathway / positive regulation of interferon-alpha production / positive regulation of type I interferon production / positive regulation of macroautophagy / canonical NF-kappaB signal transduction / positive regulation of autophagy / negative regulation of canonical NF-kappaB signal transduction / activation of innate immune response / antiviral innate immune response / negative regulation of TORC1 signaling / Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 / Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation / TICAM1-dependent activation of IRF3/IRF7 / positive regulation of interferon-beta production / positive regulation of TORC1 signaling / Regulation of innate immune responses to cytosolic DNA / T cell activation / Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) / PINK1-PRKN Mediated Mitophagy / Negative regulators of DDX58/IFIH1 signaling / peptidyl-threonine phosphorylation / phosphoprotein binding / Regulation of TNFR1 signaling / response to virus / DDX58/IFIH1-mediated induction of interferon-alpha/beta / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of peptidyl-serine phosphorylation / mitotic cell cycle / TRAF3-dependent IRF activation pathway / peptidyl-serine phosphorylation / protein phosphatase binding / defense response to virus / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / nucleic acid binding / non-specific serine/threonine protein kinase / protein kinase activity / defense response to Gram-positive bacterium / inflammatory response / protein phosphorylation / intracellular membrane-bounded organelle / innate immune response / negative regulation of gene expression / protein serine kinase activity / protein serine/threonine kinase activity / SARS-CoV-2 activates/modulates innate and adaptive immune responses / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / identical protein binding / cytosol / cytoplasm類似検索 - 分子機能 : / Tbk1/Ikki binding domain / TBD domain / TANK binding kinase 1, ubiquitin-like domain / TANK-binding kinase 1, coiled-coil domain 1 / TANK-binding kinase 1 coiled-coil domain 1 / TANK binding kinase 1 ubiquitin-like domain / : / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...: / Tbk1/Ikki binding domain / TBD domain / TANK binding kinase 1, ubiquitin-like domain / TANK-binding kinase 1, coiled-coil domain 1 / TANK-binding kinase 1 coiled-coil domain 1 / TANK binding kinase 1 ubiquitin-like domain / : / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 5-azacytidine-induced protein 2 / Serine/threonine-protein kinase TBK1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 1.451 Å |
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データ登録者 | Li, F. / Xie, X. / Liu, J. / Pan, L. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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the National Natural Science Foundation of China | 31470749 | 中国 | National Basic Research Program of China | 2013CB836900 | 中国 |
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引用 | ジャーナル: Nat Commun / 年: 2016 タイトル: Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins. 著者: Li, F. / Xie, X. / Wang, Y. / Liu, J. / Cheng, X. / Guo, Y. / Gong, Y. / Hu, S. / Pan, L. |
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履歴 | 登録 | 2015年11月11日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2016年9月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月20日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_oper_list Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation |
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