登録情報 | データベース: PDB / ID: 5ecj |
---|
タイトル | Crystal structure of monobody Mb(S4) bound to Prdm14 in complex with Mtgr1 |
---|
要素 | - Monobody Mb(S4)
- PR domain zinc finger protein 14,Protein CBFA2T2
|
---|
キーワード | GENE REGULATION/TRANSCRIPTION / TRANSFERASE / PROTEIN BINDING / GENE REGULATION-TRANSCRIPTION complex |
---|
機能・相同性 | 機能・相同性情報
: / : / inner cell mass cell fate commitment / : / positive regulation of flagellated sperm motility / intestinal epithelial cell differentiation / negative regulation of fibroblast growth factor receptor signaling pathway / germ-line stem cell population maintenance / fertilization / cell fate specification ...: / : / inner cell mass cell fate commitment / : / positive regulation of flagellated sperm motility / intestinal epithelial cell differentiation / negative regulation of fibroblast growth factor receptor signaling pathway / germ-line stem cell population maintenance / fertilization / cell fate specification / stem cell population maintenance / positive regulation of stem cell population maintenance / negative regulation of Notch signaling pathway / germ cell development / homeostasis of number of cells within a tissue / epithelial cell differentiation / embryo implantation / epigenetic regulation of gene expression / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / methyltransferase activity / RNA polymerase II transcription regulatory region sequence-specific DNA binding / cell morphogenesis / chromatin DNA binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of neuron projection development / transcription corepressor activity / negative regulation of neuron projection development / regulation of gene expression / negative regulation of DNA-templated transcription / DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / RNA binding / nucleoplasm / nucleus / metal ion binding類似検索 - 分子機能 Myeloid transforming gene-related protein-1 (MTGR1) / PRDM14, PR/SET domain / CBFA2T family / NHR2-like / NHR2 domain like / TAFH/NHR1 domain superfamily / NHR1 homology to TAF / TAFH/NHR1 domain profile. / TAF homology / TAFH/NHR1 ...Myeloid transforming gene-related protein-1 (MTGR1) / PRDM14, PR/SET domain / CBFA2T family / NHR2-like / NHR2 domain like / TAFH/NHR1 domain superfamily / NHR1 homology to TAF / TAFH/NHR1 domain profile. / TAF homology / TAFH/NHR1 / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain / SET domain profile. / SET domain / Zinc finger, C2H2 type / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 PR domain zinc finger protein 14 / Protein CBFA2T2類似検索 - 構成要素 |
---|
生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 3.05 Å |
---|
データ登録者 | Gupta, A. / Koide, S. |
---|
資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA) | R01DA036887 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM090324 | 米国 |
|
---|
引用 | ジャーナル: Elife / 年: 2015 タイトル: ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation. 著者: Nady, N. / Gupta, A. / Ma, Z. / Swigut, T. / Koide, A. / Koide, S. / Wysocka, J. |
---|
履歴 | 登録 | 2015年10月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2015年12月2日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2016年5月4日 | Group: Database references |
---|
改定 1.2 | 2017年9月20日 | Group: Author supporting evidence / Derived calculations / カテゴリ: pdbx_audit_support / pdbx_struct_oper_list Item: _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
---|
改定 1.3 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
---|
改定 1.4 | 2024年3月6日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|