Entry Database : PDB / ID : 5ecj Structure visualization Downloads & linksTitle Crystal structure of monobody Mb(S4) bound to Prdm14 in complex with Mtgr1 ComponentsMonobody Mb(S4) PR domain zinc finger protein 14,Protein CBFA2T2 DetailsKeywords GENE REGULATION/TRANSCRIPTION / TRANSFERASE / PROTEIN BINDING / GENE REGULATION-TRANSCRIPTION complexFunction / homology Function and homology informationFunction Domain/homology Component
: / : / inner cell mass cell fate commitment / intestinal epithelial cell differentiation / positive regulation of flagellated sperm motility / negative regulation of fibroblast growth factor receptor signaling pathway / germ-line stem cell population maintenance / : / fertilization / cell fate specification ... : / : / inner cell mass cell fate commitment / intestinal epithelial cell differentiation / positive regulation of flagellated sperm motility / negative regulation of fibroblast growth factor receptor signaling pathway / germ-line stem cell population maintenance / : / fertilization / cell fate specification / stem cell population maintenance / positive regulation of stem cell population maintenance / negative regulation of Notch signaling pathway / germ cell development / epigenetic regulation of gene expression / homeostasis of number of cells within a tissue / epithelial cell differentiation / embryo implantation / Transferases; Transferring one-carbon groups; Methyltransferases / methyltransferase activity / RNA polymerase II transcription regulatory region sequence-specific DNA binding / cell morphogenesis / chromatin DNA binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of neuron projection development / transcription corepressor activity / negative regulation of neuron projection development / regulation of gene expression / negative regulation of DNA-templated transcription / DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / RNA binding / nucleoplasm / nucleus / metal ion binding Similarity search - Function Myeloid transforming gene-related protein-1 (MTGR1) / PRDM14, PR/SET domain / CBFA2T family / NHR2-like / NHR2 domain like / TAFH/NHR1 domain superfamily / NHR1 homology to TAF / TAFH/NHR1 domain profile. / TAF homology / TAFH/NHR1 ... Myeloid transforming gene-related protein-1 (MTGR1) / PRDM14, PR/SET domain / CBFA2T family / NHR2-like / NHR2 domain like / TAFH/NHR1 domain superfamily / NHR1 homology to TAF / TAFH/NHR1 domain profile. / TAF homology / TAFH/NHR1 / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain / SET domain profile. / SET domain / Zinc finger, C2H2 type / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 3.05 Å DetailsAuthors Gupta, A. / Koide, S. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA) R01DA036887 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01GM090324 United States
CitationJournal : Elife / Year : 2015Title : ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.Authors : Nady, N. / Gupta, A. / Ma, Z. / Swigut, T. / Koide, A. / Koide, S. / Wysocka, J. History Deposition Oct 20, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 2, 2015 Provider : repository / Type : Initial releaseRevision 1.1 May 4, 2016 Group : Database referencesRevision 1.2 Sep 20, 2017 Group : Author supporting evidence / Derived calculations / Category : pdbx_audit_support / pdbx_struct_oper_listItem : _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.3 Dec 11, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Mar 6, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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