Entry Database : PDB / ID : 5e7i Structure visualization Downloads & linksTitle Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 ComponentsATP-dependent RNA helicase DDX3X Details Keywords HYDROLASE / DEAD-box protein / RNA helicase / RecA foldFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of protein acetylation / CTPase activity / positive regulation of toll-like receptor 8 signaling pathway / positive regulation of toll-like receptor 7 signaling pathway / positive regulation of translation in response to endoplasmic reticulum stress / protein localization to cytoplasmic stress granule / eukaryotic initiation factor 4E binding / RNA strand annealing activity / positive regulation of chemokine (C-C motif) ligand 5 production / gamete generation ... positive regulation of protein acetylation / CTPase activity / positive regulation of toll-like receptor 8 signaling pathway / positive regulation of toll-like receptor 7 signaling pathway / positive regulation of translation in response to endoplasmic reticulum stress / protein localization to cytoplasmic stress granule / eukaryotic initiation factor 4E binding / RNA strand annealing activity / positive regulation of chemokine (C-C motif) ligand 5 production / gamete generation / RNA secondary structure unwinding / NLRP3 inflammasome complex / positive regulation of protein K63-linked ubiquitination / cellular response to arsenic-containing substance / poly(A) binding / gamma-tubulin binding / cellular response to osmotic stress / negative regulation of non-canonical NF-kappaB signal transduction / P granule / positive regulation of NLRP3 inflammasome complex assembly / cell leading edge / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / lipid homeostasis / transcription factor binding / positive regulation of interferon-alpha production / ribosomal small subunit binding / extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of type I interferon production / positive regulation of translational initiation / positive regulation of G1/S transition of mitotic cell cycle / negative regulation of protein-containing complex assembly / positive regulation of viral genome replication / negative regulation of intrinsic apoptotic signaling pathway / signaling adaptor activity / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / stress granule assembly / positive regulation of protein autophosphorylation / translation initiation factor binding / positive regulation of interferon-beta production / DNA helicase activity / ribonucleoside triphosphate phosphatase activity / intrinsic apoptotic signaling pathway / protein serine/threonine kinase activator activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / cytosolic ribosome assembly / chromosome segregation / positive regulation of translation / translational initiation / response to virus / positive regulation of protein serine/threonine kinase activity / negative regulation of cell growth / cellular response to virus / Wnt signaling pathway / mRNA 5'-UTR binding / cytoplasmic stress granule / positive regulation of non-canonical NF-kappaB signal transduction / RNA stem-loop binding / positive regulation of canonical Wnt signaling pathway / lamellipodium / positive regulation of cell growth / secretory granule lumen / ficolin-1-rich granule lumen / RNA helicase activity / cell differentiation / negative regulation of translation / intracellular signal transduction / RNA helicase / cadherin binding / positive regulation of apoptotic process / negative regulation of gene expression / innate immune response / GTPase activity / mRNA binding / centrosome / Neutrophil degranulation / positive regulation of gene expression / negative regulation of apoptotic process / positive regulation of transcription by RNA polymerase II / ATP hydrolysis activity / DNA binding / RNA binding / extracellular exosome / extracellular region / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. ... DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleotide triphosphate hydrolases / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.223 Å DetailsAuthors Floor, S.N. / Condon, K.J. / Doudna, J.A. CitationJournal : J.Biol.Chem. / Year : 2016Title : Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.Authors : Floor, S.N. / Condon, K.J. / Sharma, D. / Jankowsky, E. / Doudna, J.A. History Deposition Oct 12, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 2, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Dec 9, 2015 Group : Database referencesRevision 1.2 Feb 10, 2016 Group : Database referencesRevision 1.3 Mar 6, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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