Entry Database : PDB / ID : 5e4a Structure visualization Downloads & linksTitle Human transthyretin (TTR) complexed with (2,7-Dichloro-fluoren-9-ylideneaminooxy)-acetic acid. ComponentsTransthyretin Details Keywords TRANSPORT PROTEIN / Fluorenone based Fibrillogenesis inhibitor / TransthyretinFunction / homology Function and homology informationFunction Domain/homology Component
Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ... Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family ... Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.33 Å DetailsAuthors Ciccone, L. / Nencetti, S. / Rossello, A. / Orlandini, E. / Stura, E.A. Funding support Italy, 1items Details Hide detailsOrganization Grant number Country Ministero dell'Istruzione PRIN 20109MXHMR_007 Italy
CitationJournal : J Enzyme Inhib Med Chem / Year : 2016Title : Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR).Authors : Ciccone, L. / Nencetti, S. / Rossello, A. / Stura, E.A. / Orlandini, E. History Deposition Oct 5, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Mar 23, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Apr 27, 2016 Group : Database referencesRevision 1.2 Dec 7, 2016 Group : Database referencesRevision 1.3 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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