Entry Database : PDB / ID : 4tqp Structure visualization Downloads & linksTitle Human transthyretin (TTR) complexed with (R)-3-(9H-fluoren-9-ylideneaminooxy)-2-methyl-N-(methylsulfonyl) propionamide in a dual binding mode ComponentsTransthyretin Details Keywords HORMONE / Polyethylene glycol TTR crystallization / forward and reverse binding modes / Amyloid antagonist inhibitor / Transthyretin / fluorenone based inhibitorsFunction / homology Function and homology informationFunction Domain/homology Component
Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ... Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family ... Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.58 Å DetailsAuthors Ciccone, L. / Nencetti, S. / Rossello, A. / Orlandini, E. / Stura, E.A. CitationJournal : J Enzyme Inhib Med Chem / Year : 2015Title : X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors.Authors : Ciccone, L. / Nencetti, S. / Rossello, A. / Tepshi, L. / Stura, E.A. / Orlandini, E. History Deposition Jun 11, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 24, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Aug 26, 2015 Group : Database referencesRevision 1.2 Nov 22, 2017 Group : Derived calculations / Refinement description / Category : pdbx_struct_oper_list / softwareItem : _pdbx_struct_oper_list.symmetry_operation / _software.classificationRevision 1.3 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_special_symmetry Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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